ISSN:
0170-2041
Keywords:
Porphyrins
;
Chlorins
;
Claisen rearrangement
;
Tumor therapy, photodynamic
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis of Chlorins from the Red Blood Pigment HemeHydroxyalkylporphyrins rac-8h, k and rac-9h, k prepared from the readily accessible red blood pigment heme can be transformed into the geminally dialkylated chlorins rac-10-13 upon reaction with N,N-dimethylacetamide dimethyl acetal. The chlorins are promising candidates for application in Photodynamic Tumor Therapy (PDT). The reported synthetic method should be useful for the synthesis of natural hydroporphyrins containing geminally dialkylated structural parts.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199219920159
Permalink