ISSN:
0947-3440
Keywords:
Porphyrins
;
Chlorins
;
Estradiols
;
Quinones
;
Tumor therapy, photodynamic
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The hydroxychlorin rac-3 was prepared from the readily accessible chlorins rac-5a, b. The alcohol function of rac-3 could be used to attach an estrogen residue 28 and the hydroquinone 19 to yield the chlorin estrogen ethers 32a, b and the chlorin hydroquinone ether rac-30 respectively. The prepared chlorin estrogen derivatives might be useful as sensitizers and fluorescence markers for photodynamic therapy and other diagnostic/therapeutic applications. The chlorin hydroquinone ether is of interest as a potential artificial photosynthesis system, which contains a „natural“ chlorin as a structural subunit in contrast to previously synthesized model systems based on porphyrins.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1995199509225
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