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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 50 (1972), S. 423-433 
    ISSN: 1432-1440
    Keywords: Acute leukaemia ; cytochemistry ; electron microscopy ; lymphoblast ; myeloblast ; promyelocyte ; monocyto ; Di Guglielmo Syndrome ; Unreifzellige Leukämie ; Cytochemie ; Elektronenmikroscopie ; Lymphoblast ; Myeloblast ; Promyelocyt ; Monocyt ; Di Guglielmo-Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die leukämischen Zellen von 33 Patienten mit verschiedenen Formen unreifzelliger Leukosen wurden licht- und elektronenmikroskopisch cytochemisch untersucht. Hierdurch wurde die Klassifizierung in folgende fünf Formen ermöglicht: Lymphoblasten-Leukämie (9 Patienten); Myeloblasten-Leukämie (11 Patienten); (Pro-)Myelocyten-Leukäme (3 Patienten); Monocyten-Leukämie (8 Patienten); Di Guglielmo-Syndrom (2 Patienten). Die cytochemischen Befunde im licht- und elektronenmikroskopischen Bereich bei den einzelnen Leukämieformen wurden beschrieben und erörtert im Hinblick auf Diagnose und Klassifizierung der Leukosen und auf Abstammung und Funktion der Zellen und ihrer Organellen.
    Notes: Summary The leukaemic cells of 33 patients suffering from different forms of acute leukaemia were examined by means of light and electron microscopic cytochemistry. These methods made possible the classification into the following 5 forms of acute leukaemia: lymphoblastic leukaemia (9 patients); myeloblastic leukaemia (11 patients); (pro-) myelocytic leukaemia (3 patients); monocytic leukaemia (8 patients); Di Guglielmo-syndrome (2 patients). Light-and electron microscopic cytochemical findings concerning the different forms of leukaemia are described and discussed especially with regard to diagnosis and classification of leukaemia and to both origin and function of the leukaemic cells and of their organelles.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0584
    Keywords: Chronic myeloid leukemia ; Megakaryoblastic crisis ; Cytomechistry. Cytogenetics ; Cytophotometry ; Electron microscopy ; In vitro culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atypical megakaryoblasts (MKB) or megakaryocytes (MK) are occasionally present in the peripheral blood during the terminal development of chronic myeloid leukemia (CML). We report on a 49-year-old female suffering from Ph1 chromosome-positive CML with typical megakaryoblastic transformation in the peripheral blood and in the bone marrow. The small “blasts” were at the most only slightly larger and were occasionally even smaller than lymphocytes but showed megakaryoblastic or atypical megakaryocytic differentiation. The cytoplasmic cytochemical pattern of the atypical megakaryocytic cells was identical to that of large atypical thrombocytes. Platelet peroxidase was detected upon electron-microscopic (EM) examination. Immunologic characterization disclosed the presence of MK-specific antigens. When cultured in vitro on agar, the blasts transformed spontaneously into large mature MK, exhibiting characteristic cytochemical and immunological patterns. Cytogenetic examination of peripheral blood showed severe abnormalities. The patient did not respond to therapy and died 3 months after manifestation of the blast crisis.
    Type of Medium: Electronic Resource
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