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  • 1
    Electronic Resource
    Electronic Resource
    Clozapine induced neutropenia as an effect of decreased cytokine release
    Amsterdam : Elsevier
    Schizophrenia Research 6 (1992), S. 116 
    Details
    ISSN: 0920-9964
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0920-9964(92)90149-Y
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of clozapine on the cytokine system
    Amsterdam : Elsevier
    Schizophrenia Research 9 (1993), S. 252 
    Details
    ISSN: 0920-9964
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0920-9964(93)90575-4
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  • 3
    Electronic Resource
    Electronic Resource
    UPTAKE OF CALCIUM BY CHROMAFFIN GRANULES IN VITRO (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Partly purified chromaffin granules were incubated in vitro with Ca2+ (with trace amounts of 45Ca2+) in concentrations ranging from 4 μm to 1 mm. After incubation the granules were washed with media containing EDTA and then subjected to density gradient centrifugation (1.3 to 2.0 m-sucrose solutions) in order to characterize the particles which had taken up 45Ca2+. By using marker enzymes and various inhibitors of Ca2+ uptake into such cell particles as mitochondria it was established that under the conditions of the experiments chromaffin granules took up Ca2+ from the incubation medium. To characterize this uptake a simplified density gradient procedure was tested and found to be suitable. The uptake of Ca2+ into chromaffin granules was strongly dependent on temperature. It was not activated by ATP. The uptake was linear up to 10 min. At high calcium concentrations (above 200 μm) the rate of uptake levelled off. The uptake at 37°C was 1 nmol Ca2+/mg protein/min at a Ca2+ concentration of 500 μm. Mg2+ had no influence on Ca2+ uptake, whereas Sr2+ (1 mm) inhibited it. The methods established in this study should prove useful for a further characterization of this Ca2+ uptake into chromaffin granules which is likely to represent a useful model for the Ca2+ uptake occurring in the intact gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb10419.x
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  • 4
    Electronic Resource
    Electronic Resource
    Recombinant Human Interleukin-8 Restores Function in Neutrophils from Patients with Myelodysplastic Syndromes Without Stimulating Myeloid Progenitor Cells (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 37 (1993), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Prognosis in myelodysplastic syndrome (MDS) is not only correlated closely with blast cell count in bone marrow and chromosomal abnormalities but also correlated with decreased leucocyte count and function leading to acquisition of lethal infections. Recently, clinical trials in MDS have focused on the application of haemopoietic growth factors such as G-CSF or GM-CSF, which have proven to increase neutrophil count and function. However, these cytokines carry the risk of stimulating the malignant clone, particularly in patients with increased blast cell count. Therefore, investigation of cytokines which are able to stimulate neutrophil function without the potential risk of stimulating haemopoietic progenitor cells may be relevant for MDS.As the stimulatory effect of interleukin-8 on neutrophil function is well known, we investigated whether recombinant human IL-8 is also able to improve the function of neutrophils gained from patients with MDS. Using three different techniques—the E. coli killing assay (8 patients), the production of reactive oxygen as determined by cytochrome c reduction (7 patients) and chemiluminescence (8 patients)—a significant stimulation of neutrophil function at a concentration of 10 nM IL-8 was found in all test systems. No correlation with FAB classification was evident. On the other hand, IL-8 only mildly stimulated growth of myeloid progenitor cells in bone marrow culture of healthy individuals and MDS patients. This minimal stimulation was blocked by a neutralizing antibody directed against GM-CSF, suggesting an indirect effect of IL-8 via secondary GM-CSF release.Thus, IL-8 is able in vitro to repair the functional abnormalities of neutrophils from patients with MDS but has only a marginal influence on myeloid progenitor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb02560.x
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  • 5
    Electronic Resource
    Electronic Resource
    Priming of normal human neutrophils by tachykinins: tuftsin-like inhibition of in vitro chemotaxis stimulated by formylpeptide or interleukin-8
    Amsterdam : Elsevier
    Regulatory Peptides 36 (1991), S. 359-368 
    Details
    ISSN: 0167-0115
    Keywords: Adherence ; Inflammation ; Neuroimmunomodulation ; Phagocyte ; Sensory neuropeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(91)90069-S
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  • 6
    Electronic Resource
    Electronic Resource
    Hepatitis A in Western Austria — The epidemiological situation before the introduction of active immunisation (1994)
    Springer
    Infection 22 (1994), S. 53-55 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In mehreren europäischen Ländern wird eine sinkende Prävalenz von Antikörpern gegen das Hepatitis A Virus (anti-HAV) beobachtet. Diese Entwicklung ist bei den jüngsten Jahrgängen am stärksten ausgeprägt. 1979 waren noch 58% der Österreicher zwischen 20 und 30 anti-HAV positiv. In dieser Arbeit untersuchen wir die gegenwärtige epidemiologische Situation in Westösterreich. Nur mehr 7% der 18- bis 30jährigen haben anti-HAV. Dieser Prozentsatz steigt auf 20% (31 bis 40 Jahre) und 57% (41 bis 50 Jahre), und ist mit 87% am höchsten bei Personen über 50. Von 180 klinisch manifesten Hepatitis A-Fällen in den Jahren 1985 bis 1992 wurden 45% durch eine Reise in HAV-endemische Gebiete importiert. Bei Kindern traten 59 von 83 Fällen (71%) in Gastarbeiterfamilien auf, wobei das Virus meistens im Heimatland erworben wurde. Durch die neue Impfung wird eine Änderung der Präventionsstrategie nun möglich.
    Notes: Summary Several European countries report a decreasing prevalence of antibodies to hepatitis A virus (anti-HAV). This trend is most pronounced in the youngest age groups. In 1979, however, 58% of young Austrians aged 20 to 30 years were shown to possess anti-HAV. Here we describe the current epidemiological situation in western Austria. Prevalence of anti-HAV has decreased to 7% in those 18 to 30 years old. This percentage rises to 20% (31 to 40 years of age) and 57% (41 to 50 years of age) and is highest in those older than 50 years (87%). Of 180 cases of clinical hepatitis A occurring from 1985 to 1992 45% were imported by travel to HAV-endemic areas. Seventy-one percent of the cases in children (59/83) occurred in foreign workers' families and were also predominantly acquired abroad. A change in prevention policy should be considered in this respect, as vaccination is available now.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01780769
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of human plasmalipoproteins on erythropoietic progenitor cells in serum-free cultures (1986)
    Springer
    Annals of hematology 52 (1986), S. 191-195 
    Details
    ISSN: 1432-0584
    Keywords: Human bone marrow cells ; Erythropoiesis ; Serum-free medium ; CFU-e ; BFU-e
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to investigate the influence of human lipoproteins on CFU-e and BFU-e proliferation from human bone marrow in a serum-free system. In our previously described miniaturized agar system the main lipoprotein-density-classes from human plasma, namely very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), low density lipoproteins (LDL), high density lipoproteins2 (HDL2) and HDL3 and a mixture of all the five lipoproteins were added in rising concentrations (from 1/10 to normal human plasma concentration) to serum-free medium containing delipidated and deionized bovine serum albumin (BSA), iron saturated transferrin and erythropoietin. The results demonstrate that all lipoproteins markedly increased the CFU-e and BFU-e proliferation after 7 and 14 days of incubation, respectively. Moreover, the lipoproteins induced a shift towards a lower threshold concentration of erythropoietin. Serumlike conditions were obtained if LDL and the mixture of lipoproteins were added to serum-free medium. Furthermore, in the serum-free cultures a maturation to the mature erythrocyte could be found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320536
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  • 8
    Electronic Resource
    Electronic Resource
    Megakaryoblastic micromegakaryocytic crisis in chronic myeloid leukemia (1985)
    Springer
    Annals of hematology 51 (1985), S. 275-285 
    Details
    ISSN: 1432-0584
    Keywords: Chronic myeloid leukemia ; Megakaryoblastic crisis ; Cytomechistry. Cytogenetics ; Cytophotometry ; Electron microscopy ; In vitro culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atypical megakaryoblasts (MKB) or megakaryocytes (MK) are occasionally present in the peripheral blood during the terminal development of chronic myeloid leukemia (CML). We report on a 49-year-old female suffering from Ph1 chromosome-positive CML with typical megakaryoblastic transformation in the peripheral blood and in the bone marrow. The small “blasts” were at the most only slightly larger and were occasionally even smaller than lymphocytes but showed megakaryoblastic or atypical megakaryocytic differentiation. The cytoplasmic cytochemical pattern of the atypical megakaryocytic cells was identical to that of large atypical thrombocytes. Platelet peroxidase was detected upon electron-microscopic (EM) examination. Immunologic characterization disclosed the presence of MK-specific antigens. When cultured in vitro on agar, the blasts transformed spontaneously into large mature MK, exhibiting characteristic cytochemical and immunological patterns. Cytogenetic examination of peripheral blood showed severe abnormalities. The patient did not respond to therapy and died 3 months after manifestation of the blast crisis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320522
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