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  • Electronic Resource  (2)
  • DMSA  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Antidotes for zinc intoxication in mice (1988)
    Springer
    Archives of toxicology 61 (1988), S. 321-323 
    Details
    ISSN: 1432-0738
    Keywords: Zinc ; Mice ; Intraperitoneal administration ; Zinc antidotes ; EDTA ; DTPA ; CDTA ; d-penicilamine ; DMPS ; DMSA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration. For a i. p. dose of 0.49 mmol/kg (LD50) of zinc acetate, the i. p. administration of chelating agents at a 2∶1 and 5∶1 mole ratio resulted in a significant antidotal action for EDTA, DTPA, CDTA, d-penicillamine (d-PA), DMPS and DMSA. EGTA, l-cysteine, triethylentetraamine (TTHA), N-acetylcysteine (NAC), 4,5-dihydroxi-1,3-benzenedisulfonic acid (Tiron), sodium salicylate, glutathione, sodium diethyldithiocarbamate (DDC), 6-mercaptopurine and N-acetyl-d, l-penicillamine (NAPA) were not effective for acute zinc acetate poisoning. The therapeutic indices and therapeutic effectiveness of the most effective chelators were, respectively: EDTA (5.0, 7.0), DTPA (7.3, 13.7), CDTA (8.6, 6.3), d-PA (4.6, 1.9), DMPS (1.3, 1.0), DMSA (3.2, 5.4). DTPA, CDTA, and EDTA appear to be the most effective agents of those tested in offsetting acute zinc intoxication in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364857
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cobalt (1986)
    Springer
    Archives of toxicology 58 (1986), S. 278-281 
    Details
    ISSN: 1432-0738
    Keywords: Cobalt ; Intraperitoneal administration ; Mice ; EDTA ; DTPA ; DMSA ; N-Acetylcysteine ; Glutathione ; L-Cysteine ; D,L-penicillamine ; BAL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the chelating agents Na2Ca-ethylendiaminetetraacetate (EDTA), Na3Ca-diethylentriaminepentaacetate (DTPA), L-cysteine, 2,3-dimercaptosuccinic acid (DMSA), N-acetyl-L-cysteine (NAC), glutathione, D,L-penicillamine (D,L-PEN) and 2,3-dimercaptopropanol (BAL) on the toxicity, distribution and excretion of intraperitoneally injected cobalt were studied in male Swiss mice. To determine the effect of the various chelators on the toxicity of cobalt, various doses of CoCl2 (0.60–1.80 mmol/kg) were given, followed immediately by the IP administration of the chelator (at a dose equal to one-fourth of their respective LD50). EDTA and DTPA were the most effective. EDTA, DTPA and L-cysteine, NAC and glutathione were also the most effective in increasing the urinary excretion of cobalt and reducing the concentration of the metal in various tissues. EDTA appears to be the most effective agent of those tested in the prevention of acute cobalt intoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297121
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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