ISSN:
1432-0738
Keywords:
Gallium nitrate
;
Deferoxamine mesylate
;
Citric acid
;
Succinic acid
;
Malic acid
;
Oxalic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Twelve chelating agents were administered to mice by IP injection to compare their relative effectiveness in preventing death after a single IP injection of gallium nitrate. Na2Ca-ethylenediaminetetraacetate (EDTA), Na3Ca-diethylenetriaminepentaacetate (DTPA), dimercaptosuccinic acid (DMSA), 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), sodium diethyldithiocarbamate (DDC), L-cysteine and sodium salicylate were not effective for acute gallium nitrate intoxication. The therapeutic indices of the effective chelators were: 25.4 (deferoxamine mesylate), 35.7 (citric acid), 42.3 (succinic acid), 52.2 (malic acid) and 111.1 (oxalic acid).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00295095
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