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  • Electronic Resource  (7)
  • insulin  (3)
  • High-performance liquid chromatography  (2)
  • Magnetic resonance imaging  (2)
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  • Electronic Resource  (7)
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  • 1
    Electronic Resource
    Electronic Resource
    A high-performance liquid chromatographic assay for acid ceramidase activity in cultured fibroblasts from patients with Farber's disease and from controls
    Amsterdam : Elsevier
    Clinica Chimica Acta 173 (1988), S. 280-287 
    Details
    ISSN: 0009-8981
    Keywords: Acid ceramidase ; Cultured fibroblast ; Farber's disease ; High-performance liquid chromatography ; Sphingosine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(88)90015-0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Response of gastric inhibitory polypeptide (GIP) to oral administration of nutrients in normal and pancreatectomized dogs
    Amsterdam : Elsevier
    Regulatory Peptides 5 (1983), S. 263-272 
    Details
    ISSN: 0167-0115
    Keywords: arginine ; fat ; glucagon ; glucose ; insulin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(83)90257-4
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of glicentin-related peptides on glucagon secretion in anaesthetized dogs (1986)
    Springer
    Diabetologia 29 (1986), S. 397-401 
    Details
    ISSN: 1432-0428
    Keywords: GLI ; glicentin-related peptide ; glucagon ; insulin ; dog pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent studies have demonstrated that glicentin is released during nutrient ingestion. However, the biological function of glicentin remains unclear. In order to clarify the role of glicentin in the enteroinsular axis, the effect of glicentin-related peptides was investigated using in vivo local circulation of canine pancreas. Peaks I and II of gut glucagon-like immunoreactivity, partially purified from porcine intestinal extract by affinity chromatography and gel filtration, synthesized hexadecapeptide of N-terminal glicentin (1–16) and synthesized octapeptide of C-terminal glicentin (62–69) were administered for 10 min into the pancreaticoduodenal artery of canine pancreas. Blood samples were then drawn from the pancreaticoduodenal vein. The administration of peak I of glucagon-like immunoreactivity during arginine infusion in a dosage of 20 ng reduced the glucagon secretion by 42 pmol/1 (p〈0.05), whereas peak 11 of glucagon-like immunoreactivity (20 ng) slightly increased the plasma level of insulin, although not significantly. The administration of glicentin (1–16) in a dosage of 400 ng during saline infusion did not alter the plasma insulin level, but reduced the plasma glucagon level in the pancreaticoduodenal vein by 29 pmol/1 (p〈0.05). In addition, glicentin [62–691 in a dosage of 400 ng exerted a decrease in both the plasma insulin (40 mU/1,p〈0.05) and glucagon level (27 pmol/l,p〈0.05). The present study demonstrates the suppression of pancreatic glucagon release during the infusion of peak I glucagon-like immunoreactivity and N- or C-terminal glicentin-related peptide. Therefore, it is suggested that glicentin released during nutrient intake might inhibit the secretion of glucagon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00903352
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Insulin and glucagon in spontaneously diabetic non-obese mice (1984)
    Springer
    Diabetologia 27 (1984), S. 460-463 
    Details
    ISSN: 1432-0428
    Keywords: Non-obese diabetic mice ; pancreas ; stomach ; insulin ; glucagon ; intestine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the rôle of glucagon in the development of diabetes mellitus, spontaneously diabetic non-obese mice were studied before (group 1) and after the onset of diabetes mellitus (group 2). In group 1, fasting blood glucose and insulin in plasma and pancreas did not differ significantly, while plasma glucagon was elevated (48.9±10.4 versus control 18.6±6.0pmol/l). In group 2, the insulin content of plasma and the pancreas were markedly reduced, whereas plasma glucagon was elevated (180.9±59.1 pmol/l). When diabetic mice were treated with insulin for 4 weeks (group 3), plasma glucagon was markedly reduced compared with that of group 2 (30.3±9.0 pmol/l). In group 1, glucagon and glucagon-like immunoreactivity of the intestine were reduced. The glucagon content of the intestine was elevated in group 2. Group 3 elicited increased contents of gastric glucagon as well as intestinal glucagon-like immunoreactivity. We conclude that, in addition to insulin deficiency, hypersecretion of glucagon might contribute to the development and clinical course of diabetes mellitus in the non-obese diabetic mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273911
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    MRI of anterior spinal artery syndrome of the cervical spinal cord (1992)
    Springer
    Neuroradiology 35 (1992), S. 25-29 
    Details
    ISSN: 1432-1920
    Keywords: Anterior spinal artery syndrome ; Cervical spinal cord ; Infarct ; Magnetic resonance imaging ; Spinal angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cervical spinal cord lesions in the anterior spinal artery syndrome were delineated on magnetic resonance images (MRI) in four patients. The lesion was always seen anteriorly in the cervical cord. On T2-weighted images, the lesions appeared hyperintense relative to the normal spinal cord, while on T1-weighted images, two chronic lesions appeared hypointense, with local atrophy of the cord. In one case, repeated T1-weighted images showed no signal abnormality 4 days after the ictus, but the lesion became hypointense 18 days later, when contrast enhancement was also recognized after injection of Gd-DTPA; this sequence of intensity changes was similar to that of cerebral infarction. The extent of the lesion seen MRI correlated closely with neurological findings in all cases. Although the findings may not be specific, MRI is now the modality of choice for confirming the diagnosis in patients suspected of having an anterior spinal artery syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588273
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Adrenoleukodystrophy: detection of increased very long chain fatty acids by high-performance liquid chromatography (1983)
    Springer
    Journal of neurology 230 (1983), S. 209-215 
    Details
    ISSN: 1432-1459
    Keywords: Adrenoleukodystrophy ; Adrenomyeloneuropathy ; Fatty acids ; High-performance liquid chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mittels Hochleistungs-Flüssigkeitschromatographie wurden durch Analyse der Fettsäuren in Sphingomyelien Adrenoleukodystrophien und Adrenomyeloneuropathien untersucht. Die oben erwähnte analytische Methode erwies sich als einfach, empfindlich und exakt. Bei der Adrenoleukodystrophie und bei Patienten mit Adrenomyeloneuropathie wurden sehr lange Fettsäureketten (C26:0, C25:0 und C24:0 auf der Basis von C22:0) sowohl in Plasma und den Erythrozytenmembranen als auch in Gesamtblutproben als vermehrt erkannt. Auch in Kulturen von Hautfibroblasten von Sphingomyelien wurde eine Zunahme der langkettigen Fettsäuren nachgewiesen. In einem Fall eines heterozygoten Adrenoleukodystrophiepatienten wurden Werte die zwischen jenen der homozygoten und der Kontrollfälle lagen gefunden. Somit ist die Hochleistungs-Flüssigkeitschromatographie eine brauchbare Methode, um eine Zunahme langkettiger Fettsäuren zwecks Diagnose einer Adrenoleukodystrophie oder einer Adrenomyeloneuropathie festzustellen.
    Notes: Summary Using high-performance liquid chromatography, adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN) were diagnosed by the analysis of fatty acids in sphingomyelin. The analytical method was simple, sensitive and accurate. In ALD and AMN patients, very long chain fatty acids (C26:0, C25:0 and C24:0 on the base of C22:0) were elevated not only in plasma and erythrocyte membranes but also in whole blood samples. An increase of long chain fatty acids was also shown in sphingomyelin of cultured skin fibroblasts. One heterozygote for ALD showed intermediate values between homozygotes and controls. Thus, high-performance liquid chromatography is a valuable method to detect increased long chain fatty acids for the diagnosis of ALD or AMN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313696
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Cure of a man with solitary abscess of the brain-stem (1990)
    Springer
    Journal of neurology 237 (1990), S. 265-266 
    Details
    ISSN: 1432-1459
    Keywords: Brain-stem abscess ; Antibiotics ; Stereotactic aspiration ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 25-year-old man with lung abscess and signs of an abscess in the rostral brain-stem was cured by large doses of antibiotics and stereotactic aspiration of the abscess.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314632
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    Paper (German National Licenses)
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