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  • 1
    Electronic Resource
    Electronic Resource
    Theα isoform of protein kinase C inhibits histamine-stimulated adenylate cyclase activity in a particulate fraction of the human gastric cancer cell line HGT-1 (1995)
    Springer
    Inflammation research 44 (1995), S. 66-69 
    Details
    ISSN: 1420-908X
    Keywords: Adenylate cyclase ; Protein kinase C ; Histamine H2 receptor ; Stomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The isoform of protein kinase C responsible for the inhibition of histamine-stimulated adenylate cyclase by the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), has been investigated in a particulate fraction prepared from the human gastric cancer cell line HGT-1. Theα and∈ isoforms of protein kinase C were detected in HGT-1 cells and in a 40,000 × g particulate fraction by immunoblotting procedures. The inhibitory effect of TPA on histamine-stimulated adenylate cyclase was enhanced by the presence of Ca2+, but decreased in a concentrationdependent manner by anti-peptide antibody to protein kinase Cα, but not to protein kinase C∈. Addition of Ca2+ and TPA to the 40,000 × g particulate fraction stimulated the phosphorylation of the protein kinase C substrate myelin basic peptide 4–14. Protein kinase Cα is probably the isoform responsible for inhibition of histamine-stimulated adenylate cyclase in HGT-1 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01793214
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    13C NMR studies of tautomerism in imidazo[4,5-c]pyridines (1989)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 27 (1989), S. 992-994 
    Details
    ISSN: 0749-1581
    Keywords: 13C NMR ; Tautomerism ; Inotropism ; Imidazopyridine ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A detailed analysis of the 13C NMR spectra of the 1-N- and 3-N-methyl derivatives of 1H-2-(2,4-dimethoxyphenyl)imidazo[4,5-c]pyridine, utilizing long-range couplings and 2D 1H—13C correlation experiments, has led to an unambiguous assignment of all carbons. Comparison of these definitive assignments of C-3a and C-7a, in particular, with those of the tautomers of 1H-2-(2,4-dimethoxyphenyl)imidazo[4,5-c]pyridine has permitted confirmation of the predominance of the 1H-tautomer for the latter. In addition, previous conflicting assignments for 1H-imidazo[4,5-c]pyridine and its 3-N-methyl derivative are now resolved. Revision of these assignments leads to the conclusion that the 1H-tautomer of 1H-imidazo[4,5-c]pyridine is predominant.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260271016
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    1H and 13C NMR studies of the protonation of isomeric methoxysulmazole analogues (1990)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 28 (1990), S. 573-575 
    Details
    ISSN: 0749-1581
    Keywords: Inotropism ; Imidazopyridine ; 13C NMR ; 1H NMR Tautomerism ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The major protonation sites of six cardiotonic isomeric 2-aryl-n-methoxy-1H-imidazo[4,5-b]- and -[4,5-c]-pyridines (n = 4-7) were determined by 1H and 13C NMR methods. All the 1H-imidazo[4,5-c]pyridines and the 7-methoxy derivative of sulmazole were found to protonate at the pyridyl nitrogen. Protonation occurred at the imidazo nitrogen, however, for the 5- and 6-methoxy derivatives of sulmazole.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260280703
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    Paper (German National Licenses)
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