Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Electronic Resource  (17)
  • Protein phosphorylation  (6)
  • Histologie  (5)
  • Histopathology  (3)
  • Inorganic Chemistry  (3)
Source
Material
  • Electronic Resource  (17)
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Chromosome analyses in patients with myelodysplastic syndromes: Correlation with bone marrow histopathology and prognostic significance (1992)
    Springer
    Virchows Archiv 421 (1992), S. 47-52 
    Details
    ISSN: 1432-2307
    Keywords: Myelodysplastic syndrome ; Myelofibrosis ; Cytogenetics ; Histopathology ; Bone marrow biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chromosome analyses of bone marrow and peripheral blood cells were performed in a total of 51 patients with myelodysplastic syndromes (MDS) simultaneously with histopathological examination of resinembedded bone marrow biopsies. Diagnosis of MDS was established by histopathology according to the French-American-British (FAB) classification, and reassessed by haematological data and clinical course. Clonal karyotypic changes were found in 30 of the 51 patients (59%): in 15 of 19 (79%) patients with refractory anaemia, 7 of 11 (64%) with refractory anaemia and excess of blasts (RAEB), 6 of 10 (60%) with RAEB in transformation, and 2 of 11 (18%) with chronic myelomonocytic leukaemia. The following three features of the histopathology revealed positive correlations with karyotype abnormalities: all cases of myelofibrosis in MDS (7/51) were accompanied by chromosome aberrations, microforms of megakaryocytes with reduced nuclear lobulation were observed in 18 of 30 cases with karyotype changes, and hypocellularity of haematopoiesis was associated with aberrations of chromosome 7 in 2 of 4 cases. No positive correlations were revealed between abnormal karyotypes and the transformation to acute leukaemia. The survival times were significantly decreased in patients with complex (3 and more) karyotype changes, when compared with patients with single (1–2) chromosome aberrations or normal karyotype, independently of the FAB classification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01607138
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Diurnal modulation of phosphoenolpyruvate carboxylation in pea leaves and roots as related to tissue malate concentrations and to the nitrogen source (1996)
    Springer
    Planta 198 (1996), S. 495-501 
    Details
    ISSN: 1432-2048
    Keywords: Ammonium ; Malate ; Nitrate ; Phosphoenolpyruvate carboxylase ; Protein phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Phosphoenolpyruvate (PEP) carboxylation was measured as dark 14CO2 fixation in leaves and roots (in vivo) or as PEP carboxylase (PEPCase) activity in desalted leaf and roof extracts (in vitro) from Pisum sativum L. cv. Kleine Rheinländerin. Its relation to the malate content and to the nitrogen source (nitrate or ammonium) was investigated. In tissue from nitrate-grown plants, PEP carboxylation varied diurnally, showing an increase upon illumination and a decrease upon darkening. Diurnal variations in roots were much lower than in leaves. Fixation rates in leaves remained constantly low in continuous darkness or high in continuous light. Dark CO2 fixation of leaf slices also decreased when leaves were preilluminated for 1 h in CO2-free air, suggesting that the modulation of dark CO2 fixation was related to assimilate availability in leaves and roots. Phosphoenolpyruvate carboxylase activity was also measured in vitro. However, no difference in maximum enzyme activity was found in extracts from illuminated or darkened leaves, and the response to substrate and effectors (PEP, malate, glucose-6-phosphate, pH) was also identical. The serine/threonine protein kinase inhibitors K252b, H7 and staurosporine, and the protein phosphatase 2A inhibitors okadaic acid and cantharidin, fed through the leaf petiole, did not have the effects on dark CO2 fixation predicted by a regulatory system in which PEPCase is modulated via reversible protein phosphorylation. Therefore, it is suggested that the diurnal modulation of PEP carboxylation in vivo in leaves and roots of pea is not caused by protein phosphorylation, but rather by direct allosteric effects. Upon transfer of plants to ammonium-N or to an N-free nutrient solution, mean daily malate levels in leaves decreased drastically within 4–5 d. At that time, the diurnal oscillations of PEP carboxylation in vivo disappeared and rates remained at the high light-level. The coincidence of the two events suggests that PEPCase was de-regulated because malate levels became very low. The drastic decrease of leaf malate contents upon transfer of plants from nitrate to ammonium nutrition was apparently not caused by increased amino acid or protein synthesis, but probably by higher decarboxylation rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262634
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Acid-base-modulation of nitrate reductase in leaf tissues (1995)
    Springer
    Planta 196 (1995), S. 1-6 
    Details
    ISSN: 1432-2048
    Keywords: Acid-base loading ; Nitrate reductase ; pH regulation (intracellular) ; Protein phosphorylation ; Spinacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effect of acid or base-loading of spinach (Spinacia oleracea L.) leaf discs on the activation status of nitrate reductase (NR) in the dark and in the light was investigated. Activity of NR (NRA), measured in crude extracts of leaf discs with removed lower epidermis, which had been floating on Mes-buffer [2-(N-morpholino)ethane sulfonic acid] pH 5.2 in the dark, was at a similar low level as in whole, darkened leaves. By addition of acetate or propionic acid, butyric acid or benzoic acid, NR was activated to or beyond the light level. The pH of crude tissue extracts was decreased by 0.5–1 pH units. Tissue acidification caused an inhibition of photosynthesis and of dark CO2 fixation. The acid-induced activation of NR in vivo was largely prevented by okadaic acid, an inhibitor of Type 1 and Type 2A protein phosphatases. This indicates that acid-induced activation was mediated by protein dephosphorylation. When, on the other hand, leaf discs were illuminated on Ches-buffer (2-[ N-cyclohexylamino]ethane sulfonic acid) pH 9 in the presence of bicarbonate (80 mM), their NR was as active as in intact leaves. Addition of ammonium chloride (up to 6 mM) caused a pH increase of the tissue extract up to 0.9 pH units. At the same time NR was inactivated to the dark level. Methionine sulfoximine did not prevent the ammonium effect. Photosynthesis and dark CO2 fixation were stimulated at pH 9 by ammonium chloride (1–2· mol· m −3) and were only slightly inhibited by up to 6 mol· m−3. The modulation of NR by acid-base treatment in vivo was fully reversible. The response of the NR system to acid or base treatment is consistent with a proposed role of nitrate reduction in the cellular pH-stat. The observation also indicates that cytosolic pH changes may be involved the signal chain triggering the modulation of NR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193210
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Zytogenetik als Ergänzung zur Histopathologie am Beispiel des myelodysplastischen Syndroms (1994)
    Springer
    Der Pathologe 15 (1994), S. 286-291 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Myelodysplastisches Syndrom ; Knochenmark ; Zytogenetik ; Histopathologie ; Prognose ; Key words Myelodysplastic syndrome ; Bone marrow ; Cytogenetics ; Histopathology ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The value of cytogenetics performed simultaneously with histopathology was evaluated in patients with myelodysplastic syndrome (MDS). Clonal karyotype changes of the bone marrow cells supporting the histological diagnosis were found in 38/69 cases (55 %). The chromosome aberrations, especially complex changes, were significantly correlated to distinct histopathological findings such as atypias of the haematopoietic cell lines and myelosclerosis. Complex karyotype changes were further associated with short survival of the MDS patients. Our results demonstrate that cytogenetic analyses are helpful in supplementing the histopathological diagnoses. Recent developments in molecular cytogenetics even allow the detection of chromosomal aberrations in non-dividing cells from cytological preparations or tissue sections which may become available for routine diagnosis.
    Notes: Zusammenfassung Die Bedeutung simultaner zytogenetischer und histologischer Untersuchungen wurde bei Patienten mit myelodysplastischem Syndrom (MDS) überprüft. Die Ergebnisse zeigen, daß klonale Karyotypveränderungen der Knochenmarkzellen bei 38 der 69 (55 %) analysierten Patienten auftraten und damit häufig eine Absicherung der histologischen Diagnose erlaubten. Die Chromosomenanomalien, insbesondere komplexe Karyotypveränderungen, korrelierten signifikant mit einer Reihe histopathologischer Befunde, darunter Atypien der einzelnen hämatologischen Zellreihen und Myelosklerose. Durch den Nachweis komplexer Karyotypveränderungen war eine unabhängige prognostische Aussage möglich. Damit zeigen unsere Ergebnisse am Beispiel des MDS, daß zytogenetische Analysen eine sinnvolle Ergänzung der histologischen Untersuchung sein können. Darüber hinaus ist durch den Einsatz der molekularen Zytogenetik die Bestimmung von Chromosomenanomalien in zytologischen Ausstrichpräparaten oder Gewebeschnitten möglich, wodurch sich solche Befunde auch für die tägliche Diagnostik verwenden lassen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050056
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Das Klarzellchondrosarkom (2000)
    Springer
    Der Pathologe 21 (2000), S. 449-455 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochentumoren ; Klarzellchondrosarkom ; Histologie ; Differenzialdiagnose ; Keywords Bone tumors ; Clear-cell chondrosarcoma ; Histology ; Differential diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Clear-cell chondrosarcoma is a rare, low-malignant bone tumor. The lesion most commonly occurs in adults, generally in the 3rd or 4th decade. Clear-cell chondrosarcoma has a predilection for the epiphyses of long tubular bones, particularly the femoral head. Radiologically, it is a sharply defined radiolucent lesion. Histologically, it is characterized by large tumor cells with distinct boundaries and a clear cytoplasm. In addition to areas of conventional chondrosarcoma, there are partially mineralized trabecular osteoid formations. On the basis of 16 cases of clear-cell chondrosarcoma, we present the observations of the Hamburg Bone Tumor Register. The cases were examined according to age distribution, location, and radiological and pathomorphological criteria. The proximal femur was the most frequent location; rare manifestations in the rib, os ilium, and distal phalanx of the hand were also present. In 50% of the cases high-malignant osteosarcoma or conventional chondrosarcoma was considered. In addition to the epiphysis of the proximal femur, clear-cell chondrosarcoma can also involve other, rather unusual sites in the skeleton. Knowledge of the histomorphology of this tumor is therefore of crucial importance for the diagnosis.
    Notes: Zusammenfassung Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor. Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade. Bevorzugte Lokalisation sind die Epiphysen langer Röhrenknochen, insbesondere der Femurkopf. Radiologisch imponiert es meist als eine epiphysär gelegene, scharf begrenzte lytische Läsion. Histologisch charakteristisch sind die großen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma. Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite, z. T. mineralisierte trabekuläre Osteoidformationen. Anhand von 16 Fällen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt. Die Fälle wurden nach Altersverteilung, Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht. Das Hauptmanifestationsalter lag innerhalb der 5.–7. Lebensdekade. Das proximale Femur stellte den Hauptlokalisationsort dar. Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe, Os ilium und Grundphalanx der Hand. In 50% der Fälle wurde auswärtig zunächst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert. Da das Klarzellchondrosarkom außer in der Epiphyse des proximalen Femurs auch an anderen, eher ungewöhnlichen Stellen des Skeletts auftreten kann, ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung für die Diagnosefindung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920000417
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Zytogenetik und molekulare Untersuchungen sichern die histopathologischen Diagnosen von chronischen myelopro-liferativen Erkrankungen ab (1995)
    Springer
    Der Pathologe 16 (1995), S. 41-45 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Chronische myeloproliferative Erkrankungen ; Philadelphia-Translokation ; Zytogenetik ; Molekulargenetik ; Fluoreszenz-in-situ-Hybridisierung ; Histopathologie ; Key words Chronic myeloproliferative disorders ; Philadelphia-translocation ; Cytogenetics ; Molecular genetics ; Fluorescence in situ hybridization ; Histopathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The histopathological classification of chronic myeloproliferative disorders can be supported by applying cytogenetics and molecular genetics to the analysis of bone marrow or blood cells, as demonstrated in 253 cases evaluated. The Philadelphia translocation (9;22) is the most important genetic parameter, being specific for chronic myeloid leukemia. Conventional methods for the detection of the t(9;22) are karyotyping and Southern blot analysis of the bcr gene. The newly established technique of fluorescence in situ hybridization (FISH) allows visualization of bcr-abl fusion even in non dividing cells. Molecular cytogenetics for t(9;22) yield results that are rapid and reliable as well as easily quantifiable.
    Notes: Zusammenfassung Zytogenetische und molekulargenetische Untersuchungen von Knochenmark- oder Blutzellen sind für die histopathologische Klassifikation der chronischen myeloproliferativen Erkrankungen hilfreich, was durch die simultane Auswertung von 253 Fällen gezeigt wird. Insbesondere die Analyse der Philadelphia-Translokation (9;22) ist dabei für die Bestätigung oder den Ausschluß einer chronischen myeloischen Leukämie wichtig. Für den Nachweis der t(9;22) stehen die konventionelle Karyotypisierung mit Bestimmung des Philadelphia-Chromosoms und das Southernblotverfahren zur Analyse einer Umlagerung des bcr-Gens zur Verfügung. Durch die neuere Methode der Fluoreszenz-in-situ-Hybridisierung (FISH) kann auch eine bcr-abl-Fusion an Interphasekernen dargestellt werden. Diese molekulare Zytogenetik ist ein rasches und zuverlässiges Verfahren zum Nachweis der Philadelphia-Translokation, das zudem leicht quantifizierbare Ergebnisse liefert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050074
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Das periostale Osteosarkom Histologische Charakteristika, Präparationstechnik, Wachstumsmuster und Differentialdiagnose* (1996)
    Springer
    Der Pathologe 17 (1996), S. 86-91 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Periostales Osteosarkom ; Histologie ; Präparation ; Grading ; Key words Periosteal osteosarcoma ; Histology ; Preparation ; Grading
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Periosteal osteosarcoma is a distinct bone tumor entity with characteristic morphological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the long tubular bones, especially in the tibia and femur and is situated on the outer circumference of the tumor-bearing bone (saucerization phenomenon). In contrast to parosteal osteosarcoma, periosteal osteosarcoma is less differentiated and is believed to have a worse prognosis. In this work the histological features are described with predominantly chondroblastic differentiation of 14 cases with periosteal osteosarcoma. A horizontal preparation technique of periosteal osteosarcoma specimens allows comparison with computed tomography and is the optimal method to detect an invasion of the medullary cavity. Further studies are necessary to clarify if neoadjuvant chemotherapy could improve the prognosis of certain patients.
    Notes: Zusammenfassung Das periostale Osteosarkom stellt eine eigene Entität dar, so daß der Tumor von der Gruppe der juxtakortikalen Osteosarkome eindeutig abgegrenzt werden sollte. Der Tumor tritt überwiegend an den langen Röhrenknochen, speziell Tibia und Femur auf. Er ist durch ein breitbasiges Aufsitzen an der äußeren Circumferenz des tumortragenden Skelettabschnittes charakterisiert (Saucieren-Muster). Im Gegensatz zum parossalen Osteosarkom ist das periostale Osteosarkom niedriger differenziert und hat offenbar eine schlechtere Prognose. Die histologischen Kriterien mit einer überwiegend chondroiden Differenzierung werden anhand von 14 Fällen eigener Beobachtung beschrieben. Der horizontalen Präparation von Tumorresektaten kommt eine besondere Bedeutung im Vergleich zu den bildgebenden Verfahren und zur Erfassung von Markraumeinbrüchen zu. Es gilt in zukünftigen Studien zu klären, bei welchen Patienten mit einer neoadjuvanten Chemotherapie die Prognose verbessert werden kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050140
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Das Chondromyxoidfibrom Morphologische Variationsbreite, Lokalisation, Häufigkeit, radiologische Kriterien und Differentialdiagnose (1999)
    Springer
    Der Pathologe 20 (1999), S. 224-229 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochentumoren ; Chondromyxoidfibrom ; Histologie ; Key words Bone tumors ; Chondromyxoid fibroma ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Chondromyxoid fibroma is a rare benign bone tumor, accounting for less than 1% of all bone tumors. The peak age incidence is the second and third decade of life. Chondromyxoid fibrom occurs in the metaphyseal parts of the major tubular bones, predominantly of the lower extremity. Roentgenograms show, in most cases, a well-demarcated radiolucent lesion. The classic histological feature of a chondromyxoid fibroma is stellate or spindle-shaped cells arranged in lobules in a myxoid or chondroid background. Analysis of 40 chondromyxoid fibromas demonstrates the morphological variation of this tumor. Cases were examined for age distribution, localization, and radiological and histological features. In 85% we found the typical histomorphological pattern. Recurrence rate was 12.5%. In four cases the appearance was uncharacteristic and differentiation from other tumors such as chondroblastoma or chondrosarcoma was quite difficult. By adhering to strict histomorphological criteria, definite diagnosis of chondromyxoid fibroma can be made in most cases.
    Notes: Zusammenfassung Das Chondromyxoidfibrom ist ein seltener gutartiger Knochentumor. Seine Häufigkeit beträgt weniger als 1% aller primären Knochentumoren. Das Hauptmanifestationsalter ist die 2. und 3. Lebensdekade. Der Tumor ist überwiegend in der Metaphyse langer Röhrenknochen lokalisiert, insbesondere der unteren Extremität. Radiologisch stellt er in den meisten Fällen eine scharf begrenzte, osteolytische Läsion dar. Histologisch zeigt er einen lobulären Aufbau mit einer chondroiden oder myxoiden Grundmatrix. Die Zellen sind spindelig bis sternförmig. Anhand von 40 Chondromyxoidfibromen soll die morphologische Variationsbreite dieser Tumorentität dargestellt werden. Die Fälle wurden nach Altersverteilung, Lokalisation und radiologischen sowie pathomorphologischen Kriterien untersucht. In 85% der untersuchten Fälle fanden sich die typischen histomorphologischen Kriterien des Chondromyxoidfibroms. Bei 5 Patienten (12,5%) kam es zu einem Rezidiv. 4 Fälle zeigten ein uncharakteristisches Bild und waren nur bedingt von anderen Knochentumoren (Chondroblastom, Chondrosarkom) abzugrenzen. Bei Beachtung strenger histomorphologischer Kriterien aber kann die Diagnose Chondromyxoidfibrom in den meisten Fällen sicher gestellt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050349
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Zur histologischen Gradeinteilung der Chondrosarkome Eine qualitative und quantitative Analyse an 74 Fällen des Hamburger Knochentumorregisters (1996)
    Springer
    Der Pathologe 17 (1996), S. 18-25 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Chondrosarkom ; Knochentumoren ; Grading ; Morphometrie ; Histologie ; Key words Morphometry ; Bone neoplasma ; Chondrosarcoma ; Grading ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Chondrosarcomas are frequent malignant bone tumors. Aside from different subtypes, such as dedifferentiated, mesenchymal and clear-cell chondrosarcoma, chondrosarcomas (classical chondrosarcoma) show different grades of differentiation. The borderline between chondroma and classical chondrosarcoma is not clearly defined. The same chondrosarcoma can be graded differently at different institutes. Standardized therapy concepts are currently in preparation. As the Hamburg Bone Tumor Registry is often consulted for chondrogenic tumors, the histological criteria are based on a series of 74 chondrosarcomas recorded there. The emphasis has been laid on a classification which can be used in daily routine and which is reproducible and in agreement with the classifications of other international groups. Grade I chondrosarcomas (50 %) can be distinguished only by growth criteria. The nuclei are small and show high chromatin density. Grade II chondrosarcomas (42 %) have medium-sized, regular nuclei with loose chromatin structure. The chondrocytes of grade III cases (8 %) show polymorphic nuclei. Binucleas forms, the number of mitoses and cellularity all show considerable overlap for all three grades. So far there are no immunohistological and molecular biological methods for reliable differentiation. The therapeutic consequences of the classification into grades are thorough curettage, in the case of grade I tumors, or complete resection, for grade II and III cases. The long-term results, however, need to be confirmed by a larger number of cases. From 1991 to 1995 the method was applied and proved to be easily practicable in daily diagnostic routine. Some 104 cases of classical chondrosarcomas (grade I 53 %, grade II 39 %, grade III 8 %) were analyzed. Two pathologists both assigned the same grade in 90 % of cases.
    Notes: Zusammenfassung Das Chondrosarkom gehört zu den häufigen malignen Knochentumoren. Neben unterschiedlichen Subtypen treten unterschiedliche Differenzierungsgrade des klassischen Chondrosarkoms auf. Die Übergänge von einem Chondrom, der benignen Variante chondrogener Tumoren, und dem klassischen Chondrosarkom sind histologisch fließend. Über die Bewertung der einzelnen Tumorformen liegen unterschiedliche Befunde vor. Einheitliche Therapiekonzepte werden derzeit erarbeitet. Deshalb werden die histologischen Kriterien an einer Serie von 74 Chondrosarkomen zusammengestellt. Dabei wird Wert auf eine in der täglichen Routine brauchbare und reproduzierbare Klassifikation gelegt. Grad-I-Chondrosarkome (50 %) können nur aufgrund von Wachstumskriterien von Chondromen unterschieden werden. Die Zellkerne sind klein, chromatindicht. Grad-II-Chondrosarkome (42 %) besitzen mittelgroße, gleichmäßige Zellkerne mit einem lockeren Chromatingerüst. Bei den Grad-III-Fällen (8 %) tritt eine Kernpolymorphie der Tumorchondrozyten auf. Sog. Doppelkernformen, die Zahl an Mitosen sowie die Zelldichte sind Kriterien mit einer großen Überschneidung in den 3 Differenzierungsgraden. Die therapeutischen Konsequenzen aus der Gradeinteilung sind entweder eine sorgfältige Kürettage bei Grad-I-Tumoren oder eine weite Resektion bei Grad-II- und Grad-III-Fällen. Die Langzeitergebnisse bedürfen allerdings noch einer Bewertung an größeren Kollektiven. Das Verfahren hat sich in der täglichen diagnostischen Praxis bei 104 Fällen mit einem klassischen Chondrosarkom als sehr gut anwendbar und reproduzierbar erwiesen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050130
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Solitäre Knochenzysten Morphologische Variationsbreite, Lokalisation, Häufigkeit und Differentialdiagnose (1996)
    Springer
    Der Pathologe 17 (1996), S. 63-67 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochentumoren ; Solitäre Knochenzyste ; Histologie ; Key words Bone neoplasms ; Solitary bone cyst ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Analysis of 402 solitary bone cysts demonstrates the wide morphological variation of this cystic lesion with regard to histology and radiology. Aside from metaphyseal location in femur (33 %) and humerus (23 %), solitary bone cysts are also often located in calcaneus (11 %), tibia (11 %) and pelvis (10 %). Most patients are in the second decade of life. Differentiation between this benign lesion and malignant bone tumors is very important in daily clinical routine. The diagnosis cannot be based solely on radiological findings because of the variation of solitary bone cysts and the special forms, such as calcifying solitary bone cyst. Therefore, exact histological diagnosis is of particular importance.
    Notes: Zusammenfassung Anhand von 402 solitären Knochenzysten wird die große morphologische Variationsbreite dieser zystischen Läsionen in Histologie und Radiologie dargestellt. Neben der metaphysären Lage in Femur (33 %) und Humerus (23 %), stellen Kalkaneus (11 %), Tibia (11 %) und Becken (10 %) weitere häufige Lokalisationen solitärer Knochenzysten dar. Betroffen sind überwiegend Jugendliche in der 2. Lebensdekade. Die Abgrenzung dieser benignen Läsion gegenüber malignen Knochentumoren ist im klinischen Alltag besonders wichtig. Durch die radiologische Polymorphie der solitären Knochenzyste und ihre Sonderformen, wie die kalzifizierende solitäre Knochenzyste, ist die korrekte Diagnose allein klinisch nicht eindeutig zu stellen. Der exakten histologischen Diagnostik kommt damit besondere Bedeutung zu.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050136
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...