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  • Electronic Resource  (2)
  • Key words: Vøring margin, Ocean-Bottom Seismograph, crustal structure, volcanic continental margin.  (1)
  • UFT  (1)
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  • Electronic Resource  (2)
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  • 1
    ISSN: 1420-9136
    Keywords: Key words: Vøring margin, Ocean-Bottom Seismograph, crustal structure, volcanic continental margin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —This paper presents a crustal model derived from an Ocean Bottom Seismograph (OBS) study along the northern Vøring margin off Norway. The profile was acquired to map the crustal structure in the northernmost part of the Vøring Basin, and to link crustal models of the Lofoten and central Vøring Basin obtained by previous OBS studies. The Vøring margin, as well as the Lofoten margin to the north, was created by continental breakup between Norway and Greenland in late Paleocene-early Eocene. The rifting and continental breakup process were accompanied by intense extrusive and intrusive magmatic activities. The OBS data provide the whole crustal structure along the northern Vøring margin, in the area where the deep crustal structure cannot be resolved by conventional multichannel reflection data due to sill intrusions in the sedimentary sequence. The shallow part of the crustal model is characterized by up to 10 km thick sediments, a sequence of flood basalts and sill intrusions. The P-wave velocities in the flood basalts and sill intrusions are estimated to 5.0 km/s and 4.7–5.8 km/s, respectively. The model indicates an abrupt thickening of the upper crystalline crust from approx.3 km in the NE, to about 10 km towards the SE, with velocities of 6.0–6.2 km/s. The lower crustal velocities are not well resolved due to lack of clear refraction arrivals from the lower crust. However, the observed amplitude versus offsets are best explained by a model with a change in lower crustal velocities from 6.8 to 7.2 km/s beneath the Bivrost lineament. The modelling infers the presence of a lower crustal reflector beneath the lineament, which represents the landward continuation of the Bivrost lineament. Reflection arrivals from the Moho reveal a Moho depth of 23 km in the middle of the profile and 18– 20 km in the northeastern part of the profile. A 370 km long crustal section from the central part of the Vøring Basin to the Lofoten margin, obtained by the results of this study and previous OBS studies, shows a simple thinned continental crust on the Lofoten margin, and a high velocity lower crust underlying an upper crust of varying thickness in the Vøring Basin. The transition between these structures is situated beneath the Bivrost lineament in the lower crust, and beneath the basement high about 40 km south of the lineament in the upper crust.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-7772
    Keywords: Rectal cancer ; Adjuvant chemotherapy ; Disease-free survival ; Mitomycin C ; UFT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. This study was conducted to evaluate the significance of postoperative adjuvant chemotherapy using mitomycin C (MMC) and UFT (tegafur; uracil at 1:4 molar ratio) in combination for rectal cancer. Methods. The Japanese Foundation for Multidisciplinary Treatment of Cancer conducted a prospective randomized controlled trial in 834 patients who had undergone curative resection for rectal cancer (T3 or T4 and/or Nl, N2, or N3 according to TNM classification) from February 1986 to December 1988. The patients were randomly allocated to a treatment group (MMC/UFT, 416 patients) and a control group (surgery alone, 418 patients). For the patients in the treatment group, 20 mg of MMC was sprinkled on the operating field upon completion of surgery. MMC was injected intravenously (6 mg/m2) on day 7, and then once a month for months 1–6 after surgery. UFT was administered at 400mg/day, orally, for 1 year, beginning 3 weeks after surgery. Results. There was no difference, in the 5-year survival rate between the two groups, but the 5-year disease-free survival rate in the MMC/UFT group (68.9%) was significantly higher than that (59.3%) in the control group (P = 0.006). The 5-year cumulative local recurrence rate was significantly lower in the MMC/UFT group (11.6%) than in the control group (19.0%) (P = 0.007). Conclusion. We conclude that the adjuvant use of longterm oral UFT and intermittent MMC (i.v.) improves the disease-free survival rate of patients with curatively resected rectal cancer (T3 or T4 and/or N1, N2, or N3).
    Type of Medium: Electronic Resource
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