ISSN:
1432-0584
Keywords:
Key words Chemotherapy
;
Myelosuppression
;
Hematopoietic stem cells
;
P-glycoprotein
;
Dihydrofolate reductase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Chemoresistance genes have been identified as an impediment to anticancer drug treatment. In particular, P-glycoprotein, the product of the multidrug-resistance (MDR1) gene, plays a major role in clinical treatment failure. Conversely, expression of an MDR1 cDNA in bone marrow of transgenic animals renders hematopoietic cells chemoresistant. Efficient transfer of drug-resistance genes to normal hematopoietic progenitor cells has been achieved with the use of retroviral vectors. In this article we review approaches which use the multidrug-resistance gene to protect bone marrow from myelosuppression following chemotherapy and as a selectable markerin vivo to increase the expression of nonselectable genes which correct hereditary diseases of the hematopoietic system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770050159
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