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  • Electronic Resource  (10)
  • Physics  (8)
  • methylaminoantipyrine  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Influence of food on the pharmacokinetics of dipyrone (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 105-107 
    Details
    ISSN: 1432-1041
    Keywords: dipyrone ; methylaminoantipyrine ; food interaction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twelve healthy volunteers were given a single oral dose of dipyrone 1 g, once while fasting and once after a standard breakfast. Plasma levels of the active dipyrone metabolite — Methylaminoantipyrine (MAA) were measured and the calculated pharmacokinetic parameters were compared. Taking dipyrone with food resulted in a small delay in the mean time to peak from 1.5 h to 1.9 h (p〈0.01). However, there was no significant difference in AUC, Cmax or Kelim between fasting and nonfasting conditions. The rate of absorption, expressed as the mean Kabs, was somewhat slower in the nonfasting state, but not significantly so. It is suggested that dipyrone may be taken regardless of the times of eating.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061429
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of age on the pharmacokinetics of dipyrone (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 513-516 
    Details
    ISSN: 1432-1041
    Keywords: dipyrone ; methylaminoantipyrine ; aging ; renal function ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the dipyrone metabolite, 4-metylaminoantipyrine (MAA) was evaluated, following the administration of a single oral dose of dipyrone 1.0 g to 12 young (21–30 years) and 9 elderly (73–90 years) healthy volunteers. Maximal concentration, time to peak and absorption rate of MAA were similar for both groups. The elimination half-life was 2.6 (0.2) h for the young and 4.5 (0.5) h for the elderly subjects. Total clearance of MAA, corrected for lean body mass (LBM), was lower in the elderly than in the young 2.65 vs 3.97 ml·min−1·k−1 LBM. There was no differences between the groups in the apparent volume of distribution. A good correlation was found between the total body clearance of MAA and the creatinine clearance, which was also reduced in the elderly (r=0.61).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558078
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  • 3
    Electronic Resource
    Electronic Resource
    Polarographic study of the effect of solvents on the reaction of Na amalgam with some vinyl monomers (1973)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 11 (1973), S. 81-88 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Acrylonitrile, methacrylonitrile, ethyl acrylate, anthracene, and Na+ were studied polarographically in four solvent media: diglyme, DMSO, 25% H2O in diglyme, and liquid NH3. Cathodic shifts were observed for Na+ and anodic shifts for the vinyl monomers in DMSO, H2O and NH3. The values of ΔE = (E1/2, monomer  -  E1/2, Na+) were used in interpretation of the solvent effects observed previously for the reaction of these monomers with Na amalgam. In diglyme ΔE is very large (0.49 V for MeAN and 0.37 V) for AN, and therefore very slow reaction takes place. In DMSO, MeAN still reacts very slowly (ΔE = 0.23 V), while AN (ΔE = 0.09 V) reacts considerably faster than in diglyme and 100 times faster than MeAN in DMSO. Liquid ammonia brings both MeAN and AN to very low ΔE (0.08 V and -0.05 V, respectively), and both reactions are very fast and yield only the hydrodimers. Water, on the other hand, has a large accelerating effect on the rate, but as it is a proton donor it yields only the reduced products.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1973.170110107
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  • 4
    Electronic Resource
    Electronic Resource
    Chemical changes in polymeric photodielectric media used in holographic recording (1977)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 15 (1977), S. 1811-1818 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Photochemical response of two thick photodielectric holographic recording systems was studied by using a 488 nm argon laser line. These systems are made of poly(methyl methacrylate) or poly(methyl α-cyanoacrylate) with p-benzoquinone as sensitizer. It was found that in both systems, photochemically induced branching, followed by crosslinking of the polymeric chains provide the major effects that modulate the index of refraction of these materials. The change in polymer structure as measured by intrinsic viscosity was correlated to the change in index of refraction, by which the holographic recording process is accomplished.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1977.170150803
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  • 5
    Electronic Resource
    Electronic Resource
    Studies on anionic polymerization of lactams. Part III. Copolymerization of pyrrolidone and caprolactam (1967)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 5 (1967), S. 965-974 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: On reacting acetylcaprolactam (AcCL) and pyrrolidonate MgBr (Py-) in tetrahydrofuran solution, transacetylation takes place, giving acetylpyrrolidone (AcPy) and caprolactamate MgBr (CL-). The rate constants for the transacetylation reactions were measured at 25°C. Their values in units of liters/mole-second were: \documentclass{article}\pagestyle{empty}\begin{document}$$\begin{array}{rl} {{\rm AcCL} + {\rm Py}^ - \to {\rm AcPy} + {\rm CL}^ - } \hfill & {k_{{\rm trans}} 1 = 60 \times 10^{ - 2} }\\ {{\rm AcPy} + {\rm CL}^ - \to {\rm AcCL} + {\rm Py}^ - } \hfill & {k_{{\rm trans}} 2 = 60 \times 10^{ - 2} }\\ \end{array} $$\end{document} The rate constants for the addition reactions measured were: \documentclass{article}\pagestyle{empty}\begin{document}$$ \begin{array}{ll} {{\rm AcPy} + {\rm Py}^ - \to {\rm AcPyPy}^ - } \hfill & {k_{{\rm 11}} = 2.8 \times 10^{ - 2} }\\ {{\rm AcCL} + {\rm CL}^ - \to {\rm AcCLCL}^ - } \hfill & {k_{{\rm 22}} = 0.75 \times 10^{ - 2} }\\ {{\rm AcCL} + {\rm Py}^ - \to {\rm AcCLPy}^ - } \hfill & {k_{{\rm 21}} = 5 \times 10^{ - 2} }\\ {{\rm AcPy} + {\rm CL}^{^ - } \to {\rm AcPyCL}^ - } \hfill & {k_{{\rm 12}} = 2 \times 10^{ - 2} }\\ \end{array} $$\end{document} As the transacetylation is much faster than the addition reaction the copolymer composition should be given by the equation: \documentclass{article}\pagestyle{empty}\begin{document}$$ \begin{array}{c} [{\rm PyH}]\ {\rm in\ polymer/[CLH]\ in\ polymer}\hfill\\ \qquad\qquad\qquad\qquad\qquad\qquad= K_{\rm trans} K_{\rm acidity} [{\rm PyH}]\ {\rm in\ monomer/[CLH]\ in\ monomer}\\ \end{array} $$\end{document} where Ktrans, the transacetylation equilibrium constant, equals 0.3 while Kacidity reflects the relative acidities of the monomers and its value (from the literature) is about 0.4. Pyrrolidone is, therefore, more reactive than caprolactam in anionic copolymerization by a factor of about 8.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1967.150050502
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  • 6
    Electronic Resource
    Electronic Resource
    Mechanism of the tertiary amine-catalyzed dicyandiamide cure of epoxy resinsPresented at the 151st National Meeting of the American Chemical Society, Pittsburgh, Pa., March 1966. (1967)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 5 (1967), S. 1609-1617 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Infrared and NMR data on tertiary amine-catalyzed, dicyandiamide - epoxy resin (and model compound) systems have been utilized to elucidate the mechanism of the curing process. The early exothermic curing reaction is shown to be ring opening of the resin epoxy groups by dicyandiamide imino and amino anionic species, giving rise to N-alkyl cyanoguanidines; a minor amount of polyether formation also occurs at this time. After the exothermic reaction is essentially complete at 〈90°C., a slow, high temperature (110-200°C.) addition of hydroxyl hydrogen across the nitrile triple bond occurs, giving rise to an imino ether which then rearranges to the guanyl urea.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1967.150050711
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  • 7
    Electronic Resource
    Electronic Resource
    Study of the mechanism of formation of transparent polyacrylonitrile (1966)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 4 (1966), S. 2041-2049 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics of bulk polymerization of acrylonitrile, leading to a transparent polymer, was studied. The reaction was followed by a dilatometer specially designed for high degrees of conversion and for continuous supply of monomer during the reaction. The last stages of polymerization were followed by density determinations. It was found that the kinetic scheme did not show any irregularities, and that the major condition for obtaining a transparent polymer is a continuous supply of monomer to fill up the gaps formed by the contraction during the polymerization process.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1966.150040902
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  • 8
    Electronic Resource
    Electronic Resource
    Solvent and salt effects on reaction of Na amalgam with acrylonitrile and methacrylonitrile (1969)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 7 (1969), S. 2159-2174 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction of acrylonitrile (AN) and methacrylonitrile (MeAN) with Na amalgam was studied in diglyme solution. It was shown that addition of dimethyl sulfoxide (DMSO) increases only the rate of hydrodimerization of AN to adiponitrile, while addition of water increases only the rate of hydrogenation of AN to propionitrile. The proposed mechanism assumes two separate intermediates for these two simultaneous reactions. The reaction of MeAN with Na amalgam was found to be 100 times slower than that of AN. DMSO increases the rate of both the hydrodimerization and hydrogenation reactions via the same intermediate. Addition of quaternary ammonium salts to AN in diglyme has an effect similar to that of DMSO. The salts, however, react at very low concentrations due to accumulation of the cations on the charged amalgam surface. The effect of the size and structure of the quaternary cations was studied and is discussed.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1969.150070813
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  • 9
    Electronic Resource
    Electronic Resource
    Hydrodimerization in liquid ammonia (1971)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 9 (1971), S. 2997-3008 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The hydrodimerization of acrylonitrile (M1), ethyl acrylate (M2), and α-methyl acrylonitrile (M3) in liquid ammonia by Na amalgam was studied. It was found that the concentration of phenol, as protonating agent, affects the rate of electron transfer from the amalgam to the monomer. This was explained by assuming the active species to be the protonated monomer complex MH+. Cross hydrodimerization rate constants were measured for the three monomers. The values of the ratios obtained were: k11/k12 = 0.89, k22/k21 = 0.39, k11/k13 = 5.8, k33/k31 = 0.12, k22/k23 = 1.7, k33/k32 = 0.36.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1971.150091020
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  • 10
    Electronic Resource
    Electronic Resource
    Studies on anionic polymerization of lactams. Part II. Effect of cocatalysts on the polymerization of pyrrolidonePaper presented at the IUPAC Symposium of Macromolecular Chemistry, Prague, August 1965. For Part I see Barzakay et. al.1 (1966)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 4 (1966), S. 2211-2218 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rates of addition of pyrrolidonate magnesium bromide (PyMgBr) to N-benzoyl-, N-acetyl-, and N-methylpyrrolidone were measured in solution in tetrahydrofuran (THF). The values found for the rate constants at 25°C. were 9.5 × 10-2, 2.8 × 10-2, and 5 × 10-4 l./mole-sec., respectively. The rate constant for addition of PyMgBr to pyrrolidone was also measured and found to be 3 × 10-9l./mole-sec. Possible causes for the large difference between the values of these constants are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1966.150040915
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