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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1552-1554 
    ISSN: 1420-9071
    Keywords: Epstein-Barr virus ; beta-adrenergic receptors ; cyclic AMP synthesis ; forskolin ; adenylate cyclase ; lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproterenol-stimulated cyclic AMP synthesis was observed in transformed cells, forskolin-stimulated cyclic AMP accumulation was preserved. A parallel loss of125-iodocyanopindolol binding sites suggests that the reduction in beta-adrenergic-stimulated AMP synthesis is due to receptor down regulation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-9071
    Keywords: Cyclic AMP synthesis ; measurement in lymphocytes ; forskolin ; isoproterenol ; prostaglandin E1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Reliability of measurement of lymphocyte cyclic AMP synthesis in intact cells was estimated by taking 3 successive blood samples during a one-month period from 11 healthy volunteers. Isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation were used to evaluate the activity of these two receptor activities in human lymphocytes. Forskolin-stimulated cyclic AMP accumulation was used to evaluate the activity of the Ns/catalytic subunit. Only for forskolin was significant reliability observed. For isoproterenol and prostaglandin E1 significant reliability was observed only for male subjects.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 513-516 
    ISSN: 1432-1041
    Keywords: dipyrone ; methylaminoantipyrine ; aging ; renal function ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the dipyrone metabolite, 4-metylaminoantipyrine (MAA) was evaluated, following the administration of a single oral dose of dipyrone 1.0 g to 12 young (21–30 years) and 9 elderly (73–90 years) healthy volunteers. Maximal concentration, time to peak and absorption rate of MAA were similar for both groups. The elimination half-life was 2.6 (0.2) h for the young and 4.5 (0.5) h for the elderly subjects. Total clearance of MAA, corrected for lean body mass (LBM), was lower in the elderly than in the young 2.65 vs 3.97 ml·min−1·k−1 LBM. There was no differences between the groups in the apparent volume of distribution. A good correlation was found between the total body clearance of MAA and the creatinine clearance, which was also reduced in the elderly (r=0.61).
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 15 (1992), S. 87-92 
    ISSN: 0167-4943
    Keywords: Immunosenescence (human) ; T lymphocytes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of epidemiology 11 (1995), S. 675-684 
    ISSN: 1573-7284
    Keywords: Cohort study ; Elderly ; Longitudinal study ; Population study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The main objectives of our first cross-section of a longitudinal study of a cohort of 70 year olds in Jerusalem, are to survey the social and medical conditions of the heterogeneous elderly population and to contribute to the knowledge of aging processes for specific age-groups. Whereas, most previous surveys were conducted on homogeneous and stable population groups, the elderly of Jerusalem provide the basis for ethnographic comparisons and for assessing the impact of profound historical and personal changes. From a representative systematic sample (from a geographically sorted electoral register) of 759 persons, 605 persons replied to our home-visit questionnaire gathering data on migration history, dwelling conditions, health status, health service utilization, employment status, activities of daily living, social support, use of drugs and war experience. Later on, 463 persons attended our geriatric research institute where we gathered information from in-depth anamnesis and physical examination, as well as cognitive and psychological tests. In addition, a battery of biochemical and hematological blood tests were performed as well as urine analysis and culture, ECG and pulmonary function tests. The heterogeneity of our cohort population is demonstrated by the finding that 84% were born in 40 different countries outside of Israel. In contrast, in the seventy-year old population studied in Gothenburg, Sweden, only 3% were not native born. In the years 1996, 2001 and 2006, our initial study cohort will be re-examined and compared to control groups representing states of no-survey intervention until ages 75, 80 and 85 years old. This background paper describes the study design, protocols and procedures. The responders were found to be representative of the 70 year old Jewish population in Jerusalem as a whole, in terms of mortality and hospital utilization rates. The results of the study to be reported in subsequent papers will allow conclusions regarding all 70 year old Jews in Jerusalem to be made.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-7284
    Keywords: Cohort study ; Elderly ; Longitudinal study ; Population study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Basic background information is presented from a representative sample of 605 West Jerusalem Jewish residents aged 70 years in 1990/91. A follow-up survey of the original cohort is planned for 1996, in addition to a similar sized control group of persons not studied in 1990/91. This paper describes the demographic characteristics, marital status, household composition, migration patterns, language comprehension, education, employment status, religious practices, household conditions, health status, health service utilization, health practices, use of medications, social contacts and activities of daily living of the study population. Only 16% of the study population were born in Israel, the remainder were born in forty different countries in four continents. This article also presents some ethnic comparisons within our cohort. Some significant differences were found between ethnic sub-groups in self-reported chronic diseases. However, many of these differences disappeared when socio-economic covariates were considered. Differences were also found when specific countries were considered. Compared to Polish-born Jews, Moroccan-born Jews had lower economic status, less education, more family contacts and less faith in physicians. Moroccan-born Jews also reported more morbidity for cerebrovascular disorders, emphysema and glaucoma.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-604X
    Keywords: Keywords: Autonomic nervous system; Hemiplegic patients; Photoplethysmography; Tissue blood volume variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: The photoplethysmographic (PPG) signal, which is a measure of the systolic oscillations in the tissue blood volume, spontaneously fluctuates in the respiration rate and in lower frequencies similar to the heart rate fluctuations. In the current study, the low frequency fluctuations, which are attributed to the sympathetic nervous system activity, were obtained from PPG examinations simultaneously performed on the right and the left hands of healthy subjects and hemiplegic patients. For normal subjects, the fluctuations in the two hands were found to be correlated, demonstrating their central origin. For some of the hemiplegic patients, the coefficient of correlation between the right and the left hands was significantly lower than the normal range. The simultaneous measurement of the PPG signal fluctuations in both hands provides information on the adequate function of the autonomic nervous system.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glucagon-induced rise in plasma cyclic AMP levels was used to study glucagon-sensitive adenylate cyclase activity in aged man. No significant difference was observed in plasma cyclic AMP rise after glucagon (0.0004 mg/kg) infusion between a group of 9 older (mean age 78 years) and 9 younger individuals (mean age 31 years). A similar rise in plasma glucose levels 10–15 min after glucagon administration was observed in both the younger and older individuals. These results are discussed in relation to previous findings of reduced beta-adrenergic-stimulated adenylate cyclase activity in aged man.
    Type of Medium: Electronic Resource
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