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Digitale Medien

Pharmacological characterization of the physostigmine stimulus in rats (1988)

Jung, M. ; Perio, A. ; Worms, P. ; [weitere]

Springer

Psychopharmacology 95 (1988), S. 553-555

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Details

ISSN: 1432-2072

Schlagwort(e): Drug discrimination ; Physostigmine ; M1 receptors ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Rats were trained to discriminate 0.10 mg/kg SC physostigmine from saline in a two-lever food-reinforced task. There was generalization to the acetylcholine esterase inhibitor THA as well as to the muscarinic receptor agonists arecoline, oxotremorine and RS 86, but not to neostigmine or nicotine. The physostigmine cue was blocked by SC scopolamine hydrobromide and by ICV pirenzepine, but not by scopolamine methylbromide or by mecamylamine. These antagonism studies suggest that the discriminative cue elicited by physostigmine might be mainly mediated by central M1 receptors.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00172975

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