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  • Electronic Resource  (4)
  • Prolactin  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Demonstration of mRNAs for oxytocin and prolactin in porcine granulosa and luteal cells - Effects of these hormones on progesterone secretion in vitro
    Amsterdam : Elsevier
    FEBS Letters 204 (1986), S. 37-40 
    Details
    ISSN: 0014-5793
    Keywords: (Granulosa cell, Luteal cell) ; Hybridization ; Oxytocin ; Progesterone secretion ; Prolactin ; mRNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(86)81383-7
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Involvement of preoptic-anterior hypothalamic GABA neurons in the regulation of pituitary LH and prolactin release (1983)
    Springer
    Experimental brain research 52 (1983), S. 356-362 
    Details
    ISSN: 1432-1106
    Keywords: Preoptic ; anterior hypothalamic area ; GABA ; Muscimol ; Norepinephrine turnover ; LH ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of intraventricular injections of the highly specific gamma-amino-butyric acid (GABA) agonist muscimol (5 nmol/animal) on blood LH and prolactin levels were measured in ovariectomized (ovx) and in ovx estrogen-progesterone (OEP) primed rats. While the drug stimulated pituitary prolactin release in both experimental groups, pituitary LH release was significantly inhibited in the ovx animals. Muscimol was without any effect on LH levels in ovx-OEP primed rats. Bilateral implantation of tubes containing a muscimol-mannitol mixture into the medial preoptic/ anterior hypothalamic (MPO/AH) area abolished pulsatile LH release whereas blood prolactin values were elevated. The intraventricular injection of GABA (8 μmol) also reduced LH and increased prolactin levels in the blood. Measurements of catecholamine turnover rates in the MPO/AH and in the mediobasal hypothalamus (MBH) yielded reduced preoptic but unchanged hypothalamic norepinephrine (NE) and stimulated hypothalamic dopamine (DA) turnover. In view of the well known stimulatory involvement of the NE system in the mechanism of pulsatile LH release and the inhibitory effect of GABA and its agonist muscimol on pulsatile LH release, it is suggested that GABA inhibits NE release in the MPO/AH by the mechanism of presynaptic inhibition. The observation that muscimol is unable to suppress LH release in vox OEP-primed rats may indicate that those estrogen receptive neurons in the MPO/AH which mediate the negative feedback action of the steroid may use GABA as neurotransmitter and that they are the neurons which inhibit NE release. The inhibitory effect of locally implanted muscimol into the MPO/AH also supports this hypothesis. The facilitatory action of this implanted GABAergic drug on prolactin release points to the involvement of control mechanisms for the regulation of prolactin secretion which reside in the MPO/ AH. The stimulatory effect of intraventricularly injected GABA on hypothalamic DA turnover makes it likely that other than dopaminergic mechanisms are involved in mediating the stimulatory effect of GABA on prolactin release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238029
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    In vivo release of neurotransmitters in the medial basal hypothalamus of the monkey (1984)
    Springer
    Experimental brain research 54 (1984), S. 575-578 
    Details
    ISSN: 1432-1106
    Keywords: Push-pull cannula ; Hypothalamus ; Neurotransmitters ; LH ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In vivo release rates of norepinephrine (NE), epinephrine (E), dopamine (DA), gammaaminobutyric acid (GABA), glutamate (GLU) and beta-endorphin (βE) in the medial basal hypothalamus (MBH) of unanaesthetized female macaca fascicularis monkey, and the effects thereon of estrogen (E2) treatment, have been estimated using pushpull perfusion methodology. DA, NE, E, GABA, GLU and βE were all detectable in 30 min perfusate fractions. No direct correlation between their release rates and those of LH and PRL could be observed. E2 induced an initial decrease, then an increase, in LH and PRL secretion, and concomitant changes in the release patterns of DA, NE, E. GABA and GLU were apparent. This study demonstrates that in vivo push-pull perfusion methodology may be applied to the unanaesthetized monkey, and when combined with venous catheterization for serial blood sampling may prove to be a powerful tool in the investigation of the central molecular events governing neuroendocrine functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235484
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in mediobasal hypothalamic dopamine and GABA release: A possible mechanism underlying taurine-induced prolactin secretion (1998)
    Springer
    Amino acids 15 (1998), S. 5-11 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Taurine ; Prolactin ; Dopamine ; GABA ; HPLC ; Hypothalamus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Taurine (Tau), a putative inhibitory amino acid neurotransmitter, has been shown to stimulate prolactin (PRL) release. Using ovariectomized, estrogen-replaced adult rats we investigated initially the effect of this amino acid, injected by different routes, on PRL secretion in vivo. Tau (100–500 mg/kg) had no effect on PRL release when given i.p.; 15 min after i.c.v. injection of Tau (3μmoles), a significant increase in serum PRL levels was observed (78 ± 9 ng/ml over basal levels, p 〈 0.01 vs. controls). In vitro (cultured anterior pituitary cells) PRL release was not affected by a 5 h incubation with Tau (10−3–10−8 M). Basal dopamine (DA) or gamma-aminobutyric acid (GABA) output from superfused mediobasal hypothalamic fragments (MBH) was not affected by Tau (10−3 M or 10−5 M). However, during stimulation with KCl (50mM), Tau (10−3 M) significantly lowered DA release, and increased GABA output. It is concluded that Tau acts at a central level to increase PRL secretion, most probably by modulating the hypothalamic release of neurotransmitters controlling lactotroph function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01345276
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    Paper (German National Licenses)
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