ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Trityl-glycyl-∊-CBO-L-lysine is condensed with L-prolyl-L-valine methyl ester and, after amidification and splitting of the trityl group, glycyl-∊-CBO-L-lysyl-L-prolyl-L-valylamide is obtained. This is condensed with ditrityl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophane prepared by condensation of ditrityl-L-histidyl-L-phenylalanine with L-arginyl-L-tryptophane methyl ester and saponification. Dicyclohexyl-carbodiimide is used as a condensing agent. After splitting off the trityl groups, the final octapeptide, L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophanyl-glycyl-∊-CBO-L-lysyl-L-prolyl-L-valylamide is shown to be optically pure by leucine-aminopeptidase digestion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19580410641
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