ISSN:
0018-019X
Schlagwort(e):
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
N-CBO-L-Seryl-L-tyrosyl-L-serine methyl ester and L-methionyl-γ-benzyl-L-glutamate are prepared by different methods. Condensation by the hydrazideazide procedure affords N-CBO-L-seryl-L-tyrosyl-L-seryl-L-methionyl-γ-benzyl-L-glutamate, which is shown to be optically pure by leucine-aminopeptidase digestion. Transformation of the above N-CBO-tripeptide ester to the N-acetyltripeptide ester and condensation by the hydrazide-azide procedure with the above dipeptide gives N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-γ-benzyl-L-glutamate. The effects produced in the course of fissure of CBO- and benzyl-groups from peptides containing serine and methionine residues, using HBr and acetic acid, are studied.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/hlca.19580410640