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  • 2000-2004  (4)
  • 1980-1984
  • 1960-1964  (3)
  • 1900-1904
  • 2003  (4)
  • 1964  (3)
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  • 2000-2004  (4)
  • 1980-1984
  • 1960-1964  (3)
  • 1900-1904
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  • 1
    Electronic Resource
    Electronic Resource
    Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Bowen's disease (BD; intraepithelial squamous cell carcinoma) is therapeutically challenging because lesions, which may be multiple, are frequently located at sites that heal poorly. There is a small risk of progression to invasive carcinoma. Photodynamic therapy (PDT) is an effective treatment for certain non melanoma skin cancers, but comparison studies with other, better-established therapies are limited. Objectives To compare the efficacy and tolerability of PDT and topical 5-fluorouracil (5-FU) in BD. Methods Forty patients from two centres were randomized to either topical PDT or 5-FU. The PDT group was treated with 20% 5-aminolaevulinic acid (ALA) applied 4 h before illumination with 100 J cm−2 narrowband red light (630 ± 15 nm). 5-FU was applied to lesions for 4 weeks. A repeat treatment cycle was performed after 6 weeks if required. Results Twenty-nine of 33 (88%) lesions treated with PDT initially responded completely, compared with 22 of 33 (67%) after 5-FU. After 12 months, two recurrences in the PDT group and six in the 5-FU group reduced complete clinical clearance rates to 82% and 48%, respectively. PDT was significantly more effective (P = 0·006, odds ratio 4·78, 95% confidence interval 1·56–14·62). In the 5-FU group, severe eczematous reactions developed around seven lesions, ulceration in three and erosions in two. No such reactions occurred following PDT. There was no difference in overall pain experienced during each therapy. Conclusions Topical ALA-PDT is more effective than topical 5-FU in the treatment of BD, with fewer adverse events. ALA-PDT should be considered one of the first-line therapeutic options for BD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05033.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    CONTACT CHEMORECEPTION IN FEEDING BY PHYTOPHAGOUS INSECTS (2003)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 48 (2003), S. 455-484 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Gustatory receptors associated with feeding in phytophagous insects are broadly categorized as phagostimulatory or deterrent. No phytophagous insect is known that tastes all its essential nutrients, and the ability to discriminate between nutrients is limited. The insects acquire a nutritional balance largely "adventitiously" because leaves have an appropriate chemical composition. Sugars are the most important phagostimulants. Plant secondary compounds are most often deterrent but stimulate phagostimulatory cells if they serve as host-indicating sign stimuli, or if they are sequestered for defense or used as pheromone precursors. The stimulating effects of chemicals are greatly affected by other chemicals in mixtures like those to which the sensilla are normally exposed. Host plant selection depends on the balance of phagostimulatory and deterrent inputs with, in some oligophagous and monophagous species, a dominating role of a host-related chemical. Evolution of phytophagy has probably involved a change in emphasis in the gustatory system, not fundamentally new developments. The precise role of the gustatory systems remains unclear. In grasshoppers, it probably governs food selection and the amounts eaten, but in caterpillars there is some evidence that central feedbacks are also involved in regulating the amount eaten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ento.48.091801.112629
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  • 3
    Electronic Resource
    Electronic Resource
    Large-scale genetic differentiation of Pagrus pagrus in the Atlantic (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish biology 62 (2003), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Red porgy Pagrus pagrus from the north-eastern, north-western and south-western Atlantic were found to be genetically distinct as determined by mitochondrial DNA analysis. There were no shared composite restriction fragment haplotypes, and nucleotide sequence differences averaged 2% among these locations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1095-8649.2003.00110.x
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  • 4
    Electronic Resource
    Electronic Resource
    Lability of the Action Potential and the Recovery Cycle from Isolated Motor Axons of the Crab, Carcinus (1964)
    [s.l.] : Nature Publishing Group
    Nature 203 (1964), S. 872-873 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Tracings from original records illustrating the modification of the form of the action potential when anodal current (dashed line), and cathodal current (solid line) are applied during the repolarization phase. The normal course of repolarization is shown by the fine solid line. Action ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/203872a0
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  • 5
    Electronic Resource
    Electronic Resource
    Development of the cabbage maggot Hylemyia brassicae (Bouché) on aseptic and decaying rutabaga tissue (1964)
    Springer
    Entomologia experimentalis et applicata 7 (1964), S. 115-119 
    Details
    ISSN: 1570-7458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Die Kohlfliege, Hylemyia brassicae (Bouché), wurde vom Ei bis zur Imago auf keimfreiem Kohlrüben-Gewebe gezogen. Insgesamt verpuppten sich 17 aseptische Larven; und die 6 Männchen und 7 Weibchen, die später daraus schlüpften, waren ebenfalls bakterienfrei. Die Larven entwickelten sich nicht auf hitzesterilisiertem Gewebe, oder wenn dieses Gewebe mit fäulniserregenden Bakterien versetzt wurde. Ein Vergleich der Larvalentwicklung auf aseptischen Kohlrüben-Stücken, die mit verschiedenen Arten fäulniserregender Bakterien infiziert waren, zeigt, daß sich die Larven am besten entwickelten, wenn keine Bakterien anwesend waren oder wenn das Kohlrüben-Gewebe nur langsam faulte. Es kamen weniger Larven zur Verpuppung, und die Puparien waren am kleinsten, wenn die Larven mit Kohlrüben-Gewebe ernährt wurden, das infolge Befalls mit Erwinia atroseptica (van Hall) Jennison oder Erwinia carotovora (Jones) Holland rasch faulte. Die Verpuppungs-Prozentsätze der Larven nach Fütterung mit Kohlrüben-Stücken, die mit E. atroseptica, E. carotovora, einer unbekannten Erwinia-Art (die eine langsame Fäulnis verursacht) oder einem Gemisch von E. atroseptica und der Erwinia-Art infiziert waren, sowie in der Kontrolle (ohne Bakterien), betrugen 28, 55, 70, 81, und 75%. Eine unbekannte Erwinia-Art, die durchgängig von verschiedenen Entwicklungsstadien der Kohlfliege von Kohlrüben-Feldern isoliert werden konnte, hemmte die von E. atroseptica ausgelösten Fäulnisprozesse, wenn ein Gemisch der beiden Bakterien in Kohlrüben-Gewebestücke gebracht wurde. Dies vermag zum Teil das geringe Auftreten der Weichfäule auf Kohlrüben-Feldern zu erklären, die von Kohlfliegen befallen sind.
    Notes: Abstract The cabbage maggot, Hylemyia brassicae (Bouché) was reared from egg to adult under aseptic conditions on rutabaga (Swede; Brassica napus napobrassica). No larvae survived either on contaminated or uncontaminated rutabaga plugs sterilized by heat. A comparison of larval development on rutabaga inoculated with several species of decay-producing bacteria showed that larvae developed best on healthy uncontaminated rutabaga tissue or on rutabaga tissue that decayed slowly. Survival was lowest and puparia were smallest when larvae fed on plugs that were decayed rapidly by virulent soft-rot bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305046
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  • 6
    Electronic Resource
    Electronic Resource
    The relation of the cabbage maggot, Hylemyia brassicae (Bouché), to decay in some cruciferous crops (1964)
    Springer
    Entomologia experimentalis et applicata 7 (1964), S. 1-8 
    Details
    ISSN: 1570-7458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Es wurde die Beziehung zweier Kohlfliegen-Populationen (Hylemyia brassicae Bouché) zu fäulniserregenden Bakterien an Kreuzblütlern in Verbindung mit dem von den Larven verursachten Schaden untersucht. 92 bez. 90% der Eier und 100 bez. 35% der Puparien, die sich an Kohlrüben und Chinakohl entwickelten, trugen pathogene Bakterien. Pathogene Kulturen wurden von 44% der Präpuppen-Häute aus Puparien der Chinakohl-Populationen erhalten. Die Larven vermochten fäulniserregende Bakterien wirksam auf gesunde Gewebe zu übertragen und förderten die Entwicklung und Ausbreitung der Fäule. Beim Schlüpfen waren die Imagines innerlich nicht stark kontaminiert, beschmierten sich aber offenbar äußerlich durch Kontakt mit dem Inneren der Puppengehäuse und der Präpuppen-Häute. Ein als Erwinia spec. identifizierter Bakterientyp konnte durchgängig von allen Stadien der Kohlfliege isoliert werden, die sich an Kohlrüben entwickelten. Er verursacht bei Kohlrüben eine langsame nekrotische Fäulnis und dunkle Verfärbung der befallenen Gewebe. Dieses Bakterium scheint antagonistisch zu anderen Bakterien zu sein, da nur sehr wenige andere Keime mit Stadien der Insekten dieser Population vergesellschaftet gefunden wurden. Umgekehrt fanden sich viele verschiedene Bakterientypen auf Stadien der auf dem Chinakohl lebenden Kohlfliegen. Die Virulenz der pathogenen Kulturen variierte beträchtlich, jedoch verursachten alle irgendeine Art der Weichfäule. Einige dieser aus dem Inneren oberflächlich sterilisierter Puparien isolierten Kulturen wurden als Pseudomonas spec. and Aerobacter spec. bestimmt. Die Art der bakteriellen Kontamination der Kohlfliege scheint hauptsächlich von der Empfänglichkeit ihrer kreuzblütigen Wirtspflanzen gegenüber verschiedenen Typen der Fäulnis nach Verletzung durch die Kohlfliegenmaden abhängig zu sein. Die allgemeinen Zusammenhänge zwischen dem Insekt und den fäulniserregenden Bakterien werden beschrieben.
    Notes: Abstract Bacteria pathogenic to crucifers were isolated from 92% of the eggs from flies of the cabbage maggot, Hylemyia brassicae (Bouché) of a population from rutabaga (Swede; Brassica napus napobrassica) and from 90% of those from a population from Chinese cabbage (Brassica pekinensis). The larvae transmitted the decay-causing bacteria to healthy tissues and aided in the development and spread of the rot. Of bacterial isolates from the interior of surface-sterile puparia, decay was caused by 100% of those from the rutabaga population and 35% of those from Chinese cabbage. Pathogenic cultures were also obtained from 44% of the prepupal linings of the Chinese cabbage population. The light internal contamination of adults at eclosion showed that the flies became contaminated externally from the interior of the puparia. The two populations of H. brassicae studied were contaminated with distinctly different types of bacteria. Erwinia sp., the predominant isolate from the rutabaga population, grew best on rutabaga. It caused a slow necrotic collapse and a dark pigmentation of the tissues, but not a soft-rot. Many different types of bacterial contaminants were associated with the stages of the cabbage maggot from Chinese cabbage. Green pigmenting, non-pathogenic forms were very prevalent. All pathogenic cultures caused some type of soft-rot. Some of these cultures were identified as Pseudomonas sp. and Aerobacter sp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369164
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  • 7
    Electronic Resource
    Electronic Resource
    The yrast spectroscopy of neutron-rich nuclei produced in deep-inelastic processes (2003)
    Springer
    The European physical journal 20 (2003), S. 111-112 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. The highly sensitive GASP array at the INFN Legnaro Laboratory was used to study the $\gamma$ -ray de-excitation of neutron-rich nuclei produced in the deep-inelastic processes which occur when 230 MeV 36S ions interact with a target of 176Yb. Yrast decay schemes were identified in over forty target-like fragments and in over twenty projectile-like fragments. Analysis of the data has resulted in extensions to the yrast decay sequences of the target-like species, 176Hf, 166Er, 172Yb, and 152Sm. New transitions have also been observed in a number of projectile-like species including 34P and 41Cl. Experimental results are compared with the results of shell model calculations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epja/i2002-10334-y
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