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  • 1995-1999
  • 1975-1979  (2)
  • 1970-1974  (2)
  • 1976  (2)
  • 1972  (2)
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Material
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  • 1995-1999
  • 1975-1979  (2)
  • 1970-1974  (2)
Year
  • 1
    Electronic Resource
    Electronic Resource
    SODIUM AND CHLORIDE FLUXES IN SYNAPTOSOMES IN VITRO (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 26 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Synaptosomes incubated in a physiological saline extrude sodium and take up potassium. As would be expected this process is completely blocked by metabolic inhibitors such as cyanide and iodoacetate. However, when metabolic inhibitors are replaced by ouabain (100 μM) there is an increase in the steady state intrasynaptosomal sodium and chloride content even though there is no change in the potassium content. The increases are prevented when synaptosomes are incubated with metabolic inhibitors in addition to ouabain. There is therefore a ouabain-insensitive process that transports sodium, chloride and concomitantly water into synaptosomes. It appears not to function when the supply of metabolic energy is inhibited. The diuretic furosemide (1 mM) in the presence of ouabain inhibits the entry of sodium and chloride without affecting the intrasynaptosomal potassium concentration. Ethacrynic acid (1 mM) has a somewhat similar effect but in addition appears to damage the synaptosome membrane.Kinetic measurements were made of the uptake of sodium, potassium and chloride under conditions of metabolic inhibition and the permeability constants of the membrane determined. Values of 0.068, 0.117 and 0.032 × 10-6 (cm s-1) were found for the permeability constants of the membrane to (respectively) sodium, potassium and chloride. Measurements of the rate of uptake in the presence of ouabain revealed an inwardly directed sodium and chloride flux of 5-20 pmol cm-2 s-1. Calculation of the fluxes from the steady state ion concentrations also reveals an inwardly directed sodium and chloride flux, though of lesser magnitude. The influx of water is less than would be expected to preserve osmotic equality suggesting that the translocation of sodium and chloride is the primary event. Although its function remains uncertain the flux has a considerable effect on the ion content of synaptosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb06480.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A CASE OF TINEA NIGRA IN BRITAIN (1972)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 87 (1972), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of tinea nigra occurring in a Caucasoid girl aged 10 is described. The infection was probably contracted in Malaya where she had lived between the ages of 2 and 4½. The course of the infection was chronic and protracted, with a tendency to recur after apparent cure. The mycological features are described and the aetiology is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1972.tb01600.x
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    Paper (German National Licenses)
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  • 3
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    Unknown
    THE STUDY OF LAW IN SOCIETY IN BRITAIN (1976)
    Beverly Hills, Calif. : Periodicals Archive Online (PAO)
    Law and society review. 10:4 (1976:Summer) 547 
    Details
    ISSN: 0023-9216
    Topics: Law
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:d430-1976-010-04-000005
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: Effect on adsorption and multiplication in mouse tissues (1972)
    Springer
    Archives of virology 36 (1972), S. 232-239 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of resistance to foot-and-mouth disease virus (FMDV) which occurs 2 days after divinyl ether-maleic only anhydride (pyran copolymer) treatment but diminishes by the 7th day was investigated. Adsorption of virus by minced infant mouse spleen, muscle, kidney, heart or liver was not affected either at 2 days or 7 days after treatment of the mice with pyran. However,in vitro multiplication of FMDV in minced kidney was affected by pyran at both times. The resistance of mice 2 days after treatment was related to absence of virus in muscle, kidney, and spleen tissues. Seven days after pyran administration, however, FMDV was recovered from muscle and spleen but not kidney. Interferon was recovered from various tissues 2 days but not 7 days after mice were injected with pyran. Other unknown polymer-induced antiviral factors as well as interferon may have been related to the resistance mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249854
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    Paper (German National Licenses)
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