ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Tritium-labelled Compound 48/80 is strongly bound by herpesvirus-infected and noninfected cells. Its potency to inhibit lecithine-biosynthesis decreases in time, despite it remains bound to cells. Cpd 48/80 and the dimer have proven to be inhibitors of choline kinase (E.C.2.7.1.32). This effect is small with respect to its potency of overall inhibition of lecithine-biosynthesis. Therefore, it is assumed that it inhibits further the choline transport through the membranes. The dimer of Cpd 48/80 exclusively inhibits lipid-biosynthesis, but does not affect giant cell formation suggesting that “receptors” for the dimer and Cpd 48/80 differ perhaps in size. There is no evidence, therefore, that lipid-biosynthesis is an essential requirement for giant cell formation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01240212
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