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  • 1
    Electronic Resource
    Electronic Resource
    Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 282 (1974), S. 143-153 
    Details
    ISSN: 1432-1912
    Keywords: DB-c-AMP ; Positive Inotropic Action ; Isometric Contraction Curve ; Isolated Ventricular and Atrial Preparations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Conflicting results exist about the influence of cyclic N6-2′-O-dibutyryl-AMP (DB-c-AMP) on myocardial contractile force. The present study was designed to examine whether the positive inotropic action of DB-c-AMP is restricted to certain model preparations or whether it can be assumed to represent a more general effect of the drug. Therefore, the effects of DB-c-AMP on myocardial force and on various parameters of the isometric contraction curve were examined in isolated electrically driven (0.5–2Hz) ventricular and atrial preparations of several mammalian species (cat, rabbit, calf, sheep, rat and guinea-pig). The following results were obtained: 1. At concentrations above 3×10−4M, DB-c-AMP exerted concentrationdependent positive inotropic effects in all ventricular preparations studied. These effects were accompanied by increases in the rates of force development and relaxation and by decreases in time to peak force and relaxation time. 2. Positive inotropic responses to DB-c-AMP were also obtained in atrial preparations of cats, rabbits, calves, sheep and rats. In guinea-pig auricles, similar effects were seen when the preparations were treated with the phosphodiesterase inhibitor papaverine. The results suggest that the positive inotropic action of DB-c-AMP is not restricted to certain model preparations and can be obtained in all cases under suitable experimental conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499029
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Response of isolated human ventricular myocardium to cyclic AMP and its dibutyryl derivative (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 701-703 
    Details
    ISSN: 1432-1440
    Keywords: Isolated human ventricular myocardium ; c-AMP ; DB-c-AMP ; Positive inotropic effect ; Isoliertes menschliches Ventrikelmyokard ; c-AMP ; DB-c-AMP ; Positiv inotroper Effekt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am isolierten menschlichen Ventrikelmyokard hatte c-AMP (10−4–10−3 M) keinen Einfluß auf die Kontraktionskraft. Im Gegensatz dazu wirkte DB-c-AMP (10−4−5·10−3 M) konzentrationsabhängig und reversibel positiv inotrop. Dieser Effekt ging einher mit einer Verkürzung von Anstiegzeit und Erschlaffungszeit der Kontraktion und wurde durch Vorbehandlung mit Propranolol nicht beeinflußt.
    Notes: Summary The contractile responses to c-AMP and DB-c-AMP were studied in isolated electrically stimulated human papillary muscle strips. C-AMP (1×10−4 to 1×10−3 M) had no effect on contractile force in all of 6 human papillary muscle preparations studied. In contrast, DB-c-AMP (10−4 to 5×10−3 M) produced a concentration-dependent and reversible positive inotropic effect which was associated by a decrease in time to peak force and in relaxation time and which was not inhibited by 10−6 M propranolol. The possibility of a clinical applicability of DB-c-AMP is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468483
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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