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  • 1
    Electronic Resource
    Electronic Resource
    Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus (2000)
    Springer
    Diabetologia 43 (2000), S. 1435-1438 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetes mellitus, endothelium, nitric oxide, tetrahydrobiopterin, endothelium-dependent vasodilation, acetylcholine, NG-monomethyl-l-arginine.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Tetrahydrobiopterin is an essential cofactor of nitric oxide synthase, and its deficiency decreases nitric oxide bioactivity. Our aim was to find whether supplementation of tetrahydrobiopterin could improve endothelial dysfunction in diabetic patients.¶Methods. Forearm blood flow responses to the endothelium-dependent vasodilator acetylcholine (0.75– 3.0 μg · 100 ml–1· min–1) and to the endothelium-independent vasodilator sodium nitroprusside (0.1–1.0 μg · 100 ml–1· min–1) before and during concomitant intra-arterial infusion of tetrahydrobiopterin (500 μg/min) were measured by venous occlusion plethysmography in 12 control subjects and 23 patients with Type II (non-insulin-dependent) diabetes mellitus.¶Results. In control subjects, tetrahydrobiopterin had no effect on the dose-response curves to acetylcholine and sodium nitroprusside. In contrast, in diabetic patients, the attenuated endothelium-dependent vasodilation to acetylcholine was considerably improved by concomitant treatment with tetrahydrobiopterin, whereas the endothelium-independent vasodilation was not affected. This beneficial effect of tetrahydrobiopterin in diabetic patients could be completely blocked by N G-monomethyl-l-arginine.¶Conclusion/interpretation. These findings suggest the possibility that endothelial dysfunction in Type II diabetes might be related to decreased availability of tetrahydrobiopterin. [Diabetologia (2000) 43: 1435–1438]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051551
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  • 2
    Electronic Resource
    Electronic Resource
    Undersensing of demand pacemakers in acute myocardial infarction (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 1319-1321 
    Details
    ISSN: 1432-1440
    Keywords: Demand-Schrittmacher ; Sensing-Anomalität ; akuter Myocardinfarkt ; Demand pacemaker ; Sensing abnormality ; Acute myocardial infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Trasient asynchronous pacing due to abnormal sensing function is reported in two patients with inserted demand pacemakers during the early phase of acute myocardial infarction. The hazards of the pacemaker induced parasystole with R on T phenomenon in conditions of enhanced electrical instability could be successfully overcome applying overdrive suppression of the inserted pacing system by external chest wall stimulation
    Notes: Zusammenfassung Bei 2 Patienten mit implantiertem Demand-Schrittmacher wurde in der Frühphase eines Myokardinfarktes vorübergehend asynchrone Schrittmachertätigkeit infolge gestörter Detektion beobachtet. Die Gefährdung durch schrittmacherinduzierte Parasystolie mit R auf T Phänomen unter Bedingungen erhöhter elektrischer Instabilität konnte erfolgreich unter Anwendung externer Overdrive-Stimulation beseitigt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478141
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  • 3
    Electronic Resource
    Electronic Resource
    Diagnostik kardiovaskulärer Erkrankungen mit Hilfe der suprasternalen M-mode Echokardiographie (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 193-204 
    Details
    ISSN: 1432-1440
    Keywords: Suprasternal M-mode echocardiography ; Cardiovascular diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The suprasternal approach can be used to image the aortic arch, the right pulmonary artery and the left atrium. Dilatation or dissections involving the aortic arch were detected echocardiographically from the suprasternal notch. The echocardiogram of the right pulmonary artery is altered in cases of acute and chronic pulmonary hypertension. Intrapulmonary thrombi in patients with acute pulmonary embolism were visualized with this technique. A volume overloading of the pulmonary circulation due to a congenital left to right shunt, as well as a decreased pulmonary blood flow due to a congenital right to left shunt causes characteristic changes in the wall motion pattern of the right pulmonary artery. Hypoplasia or aplasia of the central pulmonary arteries can be diagnosed as well. Imaging of the left atrium from the suprasternal notch may help to differentiate between supraventricular and ventricular rhythm disturbances. The suprasternal approach is therefore recommended to be used as a routine part of each echocardiographic examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731169
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  • 4
    Electronic Resource
    Electronic Resource
    Intravenous fibrinolytic therapy of acute myocardial infarction: New perspectives from plasminogen activators? (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 301-306 
    Details
    ISSN: 1432-1440
    Keywords: Myocardial infarction ; Fibrinolysis ; Plasminogen activators
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The early treatment of acute myocardial infarction has changed rapidly in recent years. Given the fact that an occlusive coronary thrombus can be found in most infarct patients within 4 h after clinical symptoms, the idea of instituting medical or mechanical recanalization of the occluded vessel is intriguing. However, invasive measures are time consuming, expensive and not freely available to a great number of patients. Thus, only i.v. fibrinolytic therapy of acute myocardial infarction will gain wider application in the near future. Several concepts have been worked out, one of which uses a high-dosage streptokinase or urokinase regimen. A different therapeutic alternative has been made possible by the development of selective fibrinolytic substances, such as the tissue-type plasminogen activator (t-PA) or the anisoylated plasminogen-streptokinase activator complex (APSAC). Preliminary clinical data have shown that the coronary artery patency rate achieved after i.v. administration of t-PA or APSAC is higher than that after conventional treatment with streptokinase or urokinase. The incidence of severe bleeding complications is low and comparable in these studies. However, until myocardial salvage has been demonstrated with early i.v. fibrinolytic therapy in acute myocardial infarction in a placebo-controlled randomized trial, this therapeutic concept will still be unsettled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711946
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  • 5
    Electronic Resource
    Electronic Resource
    Response of isolated human ventricular myocardium to cyclic AMP and its dibutyryl derivative (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 701-703 
    Details
    ISSN: 1432-1440
    Keywords: Isolated human ventricular myocardium ; c-AMP ; DB-c-AMP ; Positive inotropic effect ; Isoliertes menschliches Ventrikelmyokard ; c-AMP ; DB-c-AMP ; Positiv inotroper Effekt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am isolierten menschlichen Ventrikelmyokard hatte c-AMP (10−4–10−3 M) keinen Einfluß auf die Kontraktionskraft. Im Gegensatz dazu wirkte DB-c-AMP (10−4−5·10−3 M) konzentrationsabhängig und reversibel positiv inotrop. Dieser Effekt ging einher mit einer Verkürzung von Anstiegzeit und Erschlaffungszeit der Kontraktion und wurde durch Vorbehandlung mit Propranolol nicht beeinflußt.
    Notes: Summary The contractile responses to c-AMP and DB-c-AMP were studied in isolated electrically stimulated human papillary muscle strips. C-AMP (1×10−4 to 1×10−3 M) had no effect on contractile force in all of 6 human papillary muscle preparations studied. In contrast, DB-c-AMP (10−4 to 5×10−3 M) produced a concentration-dependent and reversible positive inotropic effect which was associated by a decrease in time to peak force and in relaxation time and which was not inhibited by 10−6 M propranolol. The possibility of a clinical applicability of DB-c-AMP is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468483
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  • 6
    Electronic Resource
    Electronic Resource
    Interaction of allopurinol with phenprocoumon in man (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 759-761 
    Details
    ISSN: 1432-1440
    Keywords: Allopurinol ; Phenprocoumon ; Arzneimittelwechselwirkungen ; Orale Antikoagulantien ; Allopurinol ; Phenprocoumon ; Drug interaction ; Oral anticoagulants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Conditions in two patients on long-term phenprocoumon (Marcumar®) treatment are reported who had signs of phenprocoumon overdosage when given simultaneously allopurinol. The determination of phenprocoumon plasma concentrations in one patient showed that phenprocoumon accumulates for several weeks during treatment with allopurinol. Signs of phenprocoumon overdosage thus can appear long time after starting allopurinol treatment.
    Notes: Zusammenfassung Wir berichten über zwei Patienten, bei denen während einer Dauertherapie mit Phenprocoumon (Marcumar®) nach Gabe von Allopurinol Zeichen der Phenprocoumonüberdosierung auftraten. Messungen der Phenprocoumonplasmakonzentration bei einem der Patienten zeigte, daß Phenprocoumon während gleichzeitiger Behandlung mit Allopurinol über mehrere Wochen kumulierte. Zeichen einer Phenprocoumonüberdosierung können demnach lange Zeit nach Beginn einer gleichzeitigen Behandlung mit Allopurinol auftreten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476963
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  • 7
    Electronic Resource
    Electronic Resource
    Estimation of pulmonary arterial pressure by measuring the size of the right pulmonary artery in the suprasternal echocardiogram (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 71-75 
    Details
    ISSN: 1432-1440
    Keywords: Pulmonary arterial pressure ; Right pulmonary artery ; Suprasternal echocardiography ; Pulmonalarteriendruck ; rechte Pulmonalarterie ; suprasternale Echokardiographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 175 Patienten wurden innerhalb von 24 h vor der Herzkatheteruntersuchung mit Hilfe der suprasternalen M-mode Echokardiographie untersucht. Es wurde geprüft, ob sich eine pulmonale Hypertonie durch Messung der Weite der rechten Pulmonalarterie im suprasternalen Strahlengang abschätzen läßt. Gruppe I bestand aus 103 Patienten ohne pulmonale Hypertonic (enddiastclich ≤12 mm Hg; Mitteldruck≤20 mm Hg). Gruppe II umfaßte 72 Patienten mit einer pulmonalen Hypertonie. Die rechte Pulmonalarterie konnte bei 91,2% der Patienten dargestellt werden. Der enddiastolische Durchmesser der rechten Pulmonalarterie in Gruppe I betrug 17.9±0.2 mm (MW±mittlerer Fehler des Mittelwertes) und korrelierte zur Körperoberfläche der Patienten (r=0.63;p〈0.001). Die Indexweite der rechten Pulmonalarterie in Gruppe I betrug 9.9±0.1 mm/m2 und unterschied sich von der in Gruppe II mit 14.1±0.4 mm/m2 (p〈0.001). Die prozentuale systolische Erweiterung der rechten Pulmonalarterie in Gruppe I betrug 21.2±0.8%, in Grupper II 9.2±0.8% (p〈0.001). Die Indexweite der rechten Pulmonalarterie korrelierte zum enddiastolischen Pulmonalarteriendruck (r=0.82;p〈0.001). Die prozentuale systolische Erweiterung zeigte eine negative log-lineare Beziehung zum diastolischen Pulmonalarteriendruck (r=0.67;p〈0.001). Eine pulmonale Druckerhöhung kann über die veränderte Weite der rechten Pulmonalarterie und dem Bewegungsmuster des Gefäßes im suprasternalen Strahlengang diagnostiziert werden.
    Notes: Summary We studied 175 patients within 24 h before cardiac catheterization with suprasternal echocardiography to evaluate whether pulmonary arterial hypertension can be derived by measuring the size of the right pulmonary artery. Group I consisted of 103 patients without pulmonary arterial hypertension (enddiastolic≤12 mm Hg; mean pressure ≤20 mm Hg) and group II consisted of 72 patients with pulmonary arterial hypertension. The right pulmonary artery could be imaged in 91.2% of the patients studied. The size of the right pulmonary artery at the end of diastole in group I measured 17.9±0.2 mm (mean±SEM) and correlated best to the body surface area in this group (r=0.63;p〈0.001). The respective index size amounted to 9.9±0.1 mm/m2, and was different from that in group II with 14.1±0.4 mm/m2 (p〈0.001). The systolic percent expansion of the right pulmonary artery in group I was 21.2±0.8% and in group II 9.2±0.8% (p〈0.001). The index size of the right pulmonary artery for both groups correlated best to the pulmonary enddiastolic pressure (r=0.82;p〈0.001). The systolic per cent expansion showed a negative log linear relationship to the pulmonary enddiastolic pressure (r=0.67;p〈0.001). Thus, pulmonary arterial pressure can be derived by measuring the size of right pulmonary artery with suprasternal echocardiography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716384
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  • 8
    Electronic Resource
    Electronic Resource
    Possible coumarin-like mechanism of action for cephalosporins (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 885-886 
    Details
    ISSN: 1432-1440
    Keywords: Cephalosporins ; Vitamin K1-epoxide ; Coumarin-like action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In three patients treated with cephalosporins (one patient with latamoxef, two patients with cefazedone) vitamin K1 was injected to investigate whether this was followed by an increase in vitamin K1 2,3-epoxide plasma concentrations as compared to controls. Such a rise in K1-epoxide concentrations in the plasma can be demonstrated following treatment with coumarins. This reflects an inhibition of the vitamin K1-epoxide reductase in the liver. Coumarins are thought to induce hypoprothrombinaemia by such a mechanism. In all three patients we found a considerable increase in the vitamin K1-epoxide plasma concentrations following injection of 10 mg vitamin K1, whereas in normal subjects only traces of K1-epoxide could be detected (〈0.030 µg/ml). The K1-epoxide concentrations found in our three patients treated with cephalosporins were 0.12, 0.16 and 0.19 µg/ml, respectively. This indicates that latamoxef or cefazedone might reduce clotting factor synthesis by a coumarin-like mechanism of action in these patients. Although the effect of cephalosporins in enhancing vitamin K1-epoxide plasma concentrations is less than that of coumarins, it might cause severe hypoprothrombinaemia in the presence of latent vitamin K deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712009
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of intravenous flecainide on atrial vulnerability in man (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 609-615 
    Details
    ISSN: 1432-1440
    Keywords: Atrial fibrillation ; Atrial flutter ; Electrocardiography ; Electrophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen patients were investigated by means of programmed atrial stimulation at two different driving rates: 100 and 120/min. All patients had an increased atrial vulnerability at both driving rates. After intravenous flecainide application (1 mg/kg body weight as a bolus followed by the same amount given by infusion over a period of 20 min) the increased vulnerability was abolished in 11 and 9 patients respectively. In the remaining patients the rate of induced atrial tachyarrhythmia decreased. These findings correlate with a significant prolongation of the effective refractory period of the right atrium and a significant shortening of the relative refractory period of the right atrium. It is concluded that flecainide may be effective in the treatment of atrial arrhythmias in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487339
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  • 10
    Electronic Resource
    Electronic Resource
    Haemodynamic effects of a single intravenous dose of lorcainide in patients with heart disease (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 461-465 
    Details
    ISSN: 1432-1041
    Keywords: antiarrhythmic drugs ; lorcainide ; haemodynamic effects ; i.v. dose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The cardiovascular effects of a single i.v. dose (2 mg/kg over 5 min) of lorcainide were studied in 14 patients with heart disease. In the haemodynamic part of the study (6 patients), the aortic and pulmonary systolic, diastolic and mean pressures, left ventricular systolic and end-diastolic pressures, cardiac output and the rate of rise of left ventricular pressure were measured before and for 30 min after administration of the drug. Lorcainide produced a slight and short-lasting decrease in the aortic and pulmonary systolic pressures, and all other pressure values remained unchanged. The cardiac output and systemic vascular resistance were not altered by lorcainide. It consistently depressed the rate of rise of left ventricular pressure (maximum mean decrease 19%). In the angiographic part of the study (8 patients), the ejection fraction and the mean velocity of circumferential fiber shortening were measured before and 5 min after lorcainide. In all but one patient, lorcainide decreased the ejection fraction (mean decrease 11.6%), and the mean velocity of circumferential fiber shortening was uniformly diminished by lorcainide (mean decrease 29.7%). Thus, lorcainide moderately impaired myocardial performance in patients with normal and reduced left ventricular function without producing hypotensive side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874656
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