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  • 1985-1989  (2)
  • 1975-1979
  • 1987  (2)
  • 1976
  • Corticosterone  (1)
  • Jogging  (1)
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Years
  • 1985-1989  (2)
  • 1975-1979
Year
  • 1987  (2)
  • 1976
  • 1
    ISSN: 1432-2072
    Keywords: Benzodiazepines ; Triazolopyridazines ; Corticosterone ; Anxiety ; Stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fifteen minute exposure to a novel environment plus 120 dB sound stimulation produced a three-fold increase in serum corticosterone concentrations in rats. A low dose of intraperitoneally (IP) administered chlordiazepoxide (CDP) (5 mg/kg) attenuated this response, whereas a higher dose (20 mg/kg) elevated corticosterone concentrations in rats not subjected to sound stress. Parallel results were obtained after intracerebroventricular (ICV) drug administration, with a low dose of CDP (5 μg) reducing the sound stress response and higher doses (25 and 50 μg) increasing corticosterone concentrations in unstressed animals. Thus, despite the presence of benzodiazepine (BDZ) receptors at every level of the hypothalamic-pituitary-adrenocortical axis, it appears that BDZs alter the activity of this system via an interaction with BDZ receptors in brain. CL 218,872 (2.5–20 mg/kg), a novel non-BDZ anxiolytic compound, did not attenuate the corticosterone elevation produced by sound stimulation, and also failed to alter baseline corticosterone concentrations in unstressed animals. The fact that CL 218,872 is a selective agonist for brain Type I BDZ receptors suggests that BDZs are not influencing corticosterone secretion through an interaction with this BDZ receptor subtype. Furthermore, these results indicate that stress (as measured by pituitary-adrenocortical activation) can be dissociated from anxiety (as measured by conflict paradigms), thus challenging the validity of the corticosteroid stress test as a screening procedure for anxiolytic activity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 11 (1987), S. 197-200 
    ISSN: 1432-5195
    Keywords: Hallux valgus ; Jogging ; McBride operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Vingt-et-un patients porteurs d 'un hallux valgus douloureux dans la pratique de la course à pied ont bénéficié d'une opération de McBride, modifiée selon Meary-Tomeno. Le recul moyen est de cinq ans et demi. Tous les patients ont repris la course au 6ème mois post-opératoire. Le résultat sur les douleurs de la lère articulation métatarsophalangienne et sur la métatarsalgie est en général excellent. L'opération est sans effet sur le durillon situé sous la 2ème tête métatarsienne. Lorsque la divergence entre le ler et le 2ème métatarsienne dépasse pas 14°, une bonne correction a pu être obtenue. Dans la plupart des cas, le valgus du gros orteil a été corrigé. L'opération de McBride modifiée donne constamment de bons résultats sur l'hallux valgus moyen sans arthrose métatarso-phalangienne et peut être recommandée aux patients désirant maintenir une activité sportive.
    Notes: Summary We have carried out a modified McBride procedure in 21 patients with hallux valgus which caused pain during running. They have been followed up for a mean of 5,5 years. Metatarsophalangeal pain and metatarsalgia were relieved or significantly decreased in the majority of patients, but callosities beneath the second metatarsal head were not affected. When the angle between the first and second metatarsals did not exceed 14° before operation, satisfactory correction could be obtained. In the absence of degenerative changes in the first metatarsophalangeal joint and with a moderate hallux valgus, a consistently good result was obtained in this group of active patients.
    Type of Medium: Electronic Resource
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