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  • 1975-1979  (5)
  • 1978  (5)
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  • 1975-1979  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    [3H]GLYCOGEN HYDROLYSIS IN BRAIN SLICES: RESPONSES TO NEUROTRANSMITTERS AND MODULATION OF NORADRENALINE RECEPTORS (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Different agents have been investigated for their effects on [C3H]glycogen synthesized in mouse cortical slices. Of these noradrenaline, serotonin and histamine induced clear concentration-dependent glycogenolysis.[C3H]Glycogen hydrolysis induced by noradrenaline appears to be mediated by beta-adrenergic receptors because it is completely prevented by timolol, while phentolamine is ineffective. It seems to involve cyclic AMP because it is potentiated in the presence of isobutylmethylxanthine; in addition dibutyryl cyclic AMP (but not dibutyryl cyclic GMP) promotes glycogenolysis.Lower concentrations of noradrenaline were necessary for [C3H]glycogen hydrolysis (EC50= 0.5μM) than for stimulation of cyclic AMP accumulation (EC50= 8μM).After subchronic reserpine treatment the concentration-response curve to noradrenaline was significantly shifted to the left (EC50= 0.09 ± 0.02 μM as compared with 0.49 ± 0.08 μM in saline-pretreated mice) without modifications of either the basal [C3H]glycogen level, maximal glycogenolytic effect, or the dibutyryl cAMP-induced glycogenolytic response.In addition to noradrenaline, clear concentration-dependent [3H]glycogen hydrolysis was observed in the presence of histamine or serotonin. In contrast to the partial [3H]glycogen hydrolysis elicited by these biogenic amines, depolarization of the slices by 50 mM K+ provoked a nearly total [C3H)glycogen hydrolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10464.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    RADIOIMMUNOASSAY OF METHIONINE-AND LEUCINE-ENKEPHALINS IN REGIONS OF RAT BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Radioimmunoassays (RIAs) selective for methionine-enkephalin (Met-ENK) and leucineenkephalin (Leu-ENK) have been developed using competition towards binding of 10 pM 125I-enkephalins to antibodies raised in rabbits against ENKs coupled to ovalbumin with carbodiimide. The high sensitivity of the RIAs (IC50 0.57 nm and 0.55 nm for Met- and Leu-ENK, respectively) allowed estimation of the enkephalin content in extracts of all rat brain regions. Regional levels are compared with those determined on the same extracts by a radioreceptor assay (RRA) using competition towards binding of 5 nm [3H]Leu-ENK to rat striatal membranes. Optimal conditions for killing the animals and extracting the endorphins have been carefully investigated: killing by rapid microwave irradiation was not found necessary as long as brain regions were homogenized into 0.1 n-HCl before deproteinization.Marked differences both in total endorphins (RRA) and ENKs (RIA) between regions are observed with similar ranking of the various regions: highest levels are found in striatum and hypothalamus and lowest in cerebellum and hippocampus. In each region the total ENK levels (RIA) represent only 2–13% of the total endorphins (RRA) suggesting the presence of large amounts of endorphins other than the ENKs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb12429.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High-affinity enkephalin-degrading peptidase in brain is increased after morphine (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 523-526 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Enkephalin-hydrolysing activity exhibits a considerable heterogeneity in rat brain subtractions8. Starting from the hypothesis that a specific peptidase involved in the control of enkephalin concentration in the synaptic cleft should be membrane-bound and should exhibit a high affinity for the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276523a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 603-605 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The presence of opiate receptors on noradrenergic nerve terminals was investigated by measuring 3H-naloxone binding in brain regions receiving noradrenergic inputs, after chemical destruction of noradrenergic cell bodies. For 15-40 d after the slow unilateral infusion of 6-hydroxydopamine (6-OHDA) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274603a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A gradual score to evaluate the climbing behaviour elicited by apomorphine in mice (1978)
    Springer
    Psychopharmacology 56 (1978), S. 233-234 
    Details
    ISSN: 1432-2072
    Keywords: Stereotyped behaviour ; Apomorphine ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice treated with apomorphine tend to adopt a vertical position in a stereotyped manner. A quantal evaluation of this behaviour, taking into account its frequency and duration, leads to a biphasic dose-response curve that reveals opposite actions of the dopamine agonist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431856
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    Paper (German National Licenses)
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