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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Marine biology 79 (1984), S. 177-186 
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A distinctive chlorophyll maximum was detected around 60-m depth in the western North Pacific Ocean and the South China Sea, and almost 55% of the total chlorophyll in the entire water column was found within 50 m around the subsurface chlorophyll maximum (SCM) layer. More than 70% of the chlorophyll was contained in picoplankton which passed through a 3-μm Nuclepore but retained on 0.22-μm Millipore filters at the SCM as well as the surface layers. By transmission electron microscopic observations, the picoplankton were identified as aChlorella-like coccoid green alga having a section size of 1.2 to 1.5 μm and cyanobacteria of 0.5 to 2 μm. No obvious difference in these two dominant groups was observed in the SCM and the surface samples except in numerous and heavily stacked thylakoids in the former samples.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0942-0940
    Keywords: Brain tumours ; LDH isoenzyme ; cytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lactate dehydrogenase (LDH) isoenzyme patterns in benign and malignant brain tumours were determined by means of electrophoresis of the cell extracts and selective cytochemical stain of the smears. The LDH isoenzyme distribution of the cell extracts showed a pronounced cathodal shift in the malignant gliomas and metastatic carcinomas. Normal brain tissues and histologically benign gliomas, however, showed an anodal pattern with a dominance of the H-type LDH. Schwannomas and meningiomas had a midzone isoenzyme pattern with a dominant LDH3 fraction. Pituitary adenomas usually showed the LDH pattern similar to that of the normal cerebrum. The LDH M fraction could be cytochemically verified using an inhibitory effect by 2.6 M urea in staining. Astrocytomas grades 3–4 and metastatic carcinomas were characterized by loss or marked reduction of stainability by urea treatment, while astrocytomas grades 1–2 and oligodendrogliomas were resistant to urea inhibition.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 65 (1984), S. 325-330 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A family in which two first cousins were found to have the Prader-Willi syndrome was investigated cytogenetically. Although G-banding analysis of metaphase chromosomes failed to demonstrate abnormality, close analyses on the fine prometaphase bands by G-banding and the DA-DAPI bands by double stainings revealed a distinct chromosome abnormality in this family. A reciprocal translocation, rep(14:15)(q11.2;q13), was detected in three family members: the mother, the maternal grandmother, and a maternal uncle of the proband. And, the proband and one of the first cousins had an unbalanced translocation that was derived from their carrier parents. The karyotypes of the affected cousins were determined as 46,XY or XX,-15,+der(14),rcp(14;15)(q11.2;q13). Therefore, they were considered to have an identical cytogenetic abnormality: a partial trisomy of the 14pter→q11.2 segment and a partial monosomy of the 15pter→q13 segment. Detailed clinical features of the proband and his affected cousin are described, main features associated with the Prader-Willi syndrome having been observed in both cousins. These observations support a definite relationship between the Prader-Willi syndrome and chromosome 15.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 19 (1980), S. 249-256 
    ISSN: 1432-1920
    Keywords: Dural carotid-cavernous fistula ; Dural fistula ; Magnification angiography ; Expothalmus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven patients with dural carotid-cavernous sinus fistulae were studied with selective magnification angiography. The angiographic features of this condition were analyzed in detail. The arterial plexus normally present in and around the cavernous sinus has been thought to rupture into the sinus and establish an arteriovenous fistula with an extensive dural arterial supply. Changeable angiographic and clinical findings, including spontaneous regression, can be explained on the basis of thrombosis and occlusion in the arterial network. The indications for and methods of embolization are also discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 26 (1984), S. 253-259 
    ISSN: 1432-1920
    Keywords: DSA ; vessel resolution ; digital subtraction angiography ; intraarterial DSA ; IA DSA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Comparative study was performed between IA DSA and stereoscopic magnification angiography in relation to small vessel resolution, image quality of the vessels and image quality of various pathologic lesions. The vessels of various diameters, accurately measured by stereoscopic magnification angiography, were localized on IA DSA and their resolution was carefully assessed. The vessels more than 1 mm in diameter were equally visualized on IA DSA and conventional angiography. The vessels between 1 mm and 0.5 mm showed fair resolution on IA DSA, whereas IA DSA did not resolve the vessels smaller than 0.5 mm in diameter to good advantage. In addition, image quality of the vessels on IA DSA was compared with the conventional methods. Cerebral gyrus, venous sinuses, and intracerebral veins are often shown better on DSA. The small vessels such as lenticulostriate, small cortical, thalamoperforate and meningohypophyseal arteries were not defined on DSA. Equal or better image quality was obtained in more than 85% of cases with pathologic lesions. Examinations were performed faster with lower cost and lower complication rate. Information provided by DSA was often sufficient for managements of patients. Combined use of DSA and conventional angiography will improve diagnostic accuracy and decrease the complication rate.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1459
    Keywords: Guillain-Barré syndrome ; Nerve conduction velocity ; Prognosis ; Motor paralysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Klinisch-elektrophysiologische Untersuchungen wurden bei 39 Patienten mit Guillain-Barré Syndrom durchgeführt. Es ging um die Frage, welche Elemente in der akuten Phase eine prognostische Beurteilung zulassen. Bei 16 der Patienten, was 52% des Krankengutes entspricht, wurden residuelle Symptome wie motorische Schwäche, fehlende Patellarsehnenreflexe und so weiter nachgewiesen. Das Zurückbleiben von residuellen Symptomen korrelierte mit dem Alter bei Krankheitsbeginn, das Ausmaß der Tetraparese und das Ausmaß der Sensibilitätsstörungen in der akuten Phase. Acht der zehn Patienten, die eine Verminderung der motorischen Nervenleitgeschwindigkeit in einer frühen Krankheitsphase aufwiesen, zeigten später nennenswerte Restsymptome. Tendenzmäßig schienen Restsymptome häufiger bei jenen Patienten zu sein, welche eine Verlangsamung der Leitgeschwindigkeit gemischter Nerven und eine verlängerte Latenz der H-Welle sowie der Residuallatenz aufwiesen. Elektroneurographische Untersuchungen, im besonderen die Bestimmung der motorischen Leitgeschwindigkeit, erlauben zuverlässige Rückschlüsse auf die Prognose dieses Krankheitsbildes.
    Notes: Summary Clinical and electrophysiological studies were carried out on 39 patients with the Guillain-Barré syndrome to evaluate which elements were of prognostic value during the acute phase. Residual clinical signs such as motor weakness and absent patellar tendon reflexes were found in 16 (52%) of those patients who had had a preceding illness. Persistence of deficit was significantly correlated to age at onset, the degree of quadriparesis and loss of deep sensation in the acute phase. Of the 10 patients who showed a reduction in motor nerve conduction velocity (MCV) in the early stage, 8 (80%) revealed significantly residual clinical symptoms at follow-up. There was a tendency for the incidence of residual signs to be more common in the patients with slowing of mixed nerve conduction velocity, and prolonged latency of H-wave and the residual latency. Nerve conduction studies, especially measurement of MCV, were of value as a reliable prognostic indicator in this syndrome.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The regulatory protein CRP (or CAP) fromE. coli is shown to display two distinct patterns of binding interactions with DNA-dependent RNA polymerase. The free core enzyme, and both the core and the holo polymerase when bound to single-stranded DNA, can bind CRP in a cAMP-independent association reaction. Instead, the binding of CRP to free holoenzyme and to holo or core polymerase bound to native DNA was undetectable in the absence of cAMP. The specific ligand of CRP (cAMP) strengthens distinctively this class of interactions. In no case could any release of σ-factor be demonstrated. Estimates of the dissociation constants were obtained for the various binding reactions which were investigated under quasi-physiological ionic conditions. These, together with the known values of thein vivo concentrations of CRP and RNA polymerase, suggest that the interactions described may have a functional significance.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-5117
    Keywords: brown seaweed ; antitumor activity ; fucoidan, L-1210
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 228 (1980), S. 127-134 
    ISSN: 1434-4726
    Keywords: Phytohaemagglutinin ; lokale Krebsbehandlung ; Plattenepithelkarzinom der Kieferhöhle ; Phytohemagglutinin (PHA) ; Local treatment of cancer ; Maxillary squamous cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Twenty-four patients with maxillary squamous cell carcinoma were treated with 50 μg of phytohemagglutinin (PHA), saturated into pieces of gelatin sponge, and applied to the maxillary sinus which was in advance surgically exposed via the peroral route. Treatment was combined with cobalt 60 irradiation at 4,000 rads (200 rads×20 doses over a one month period) and concurrent arterial infusion of 5-fluorouracil (5-FU) with a total dosage of 5,000 mg (250 mg× 20 doses). After 20 treatments with phytohemagglutinin, gross examination showed that tumors were no longer apparent in 83.3% of the cases treated with PHA vs. 52.6% in the control group without PHA. On histological examination, 66.6% in the PHA group showed no signs of tumors vs. 15.8% in the control group. Microscopically, the disappearance of the tumors was frequently observed in tumor of T2 more than that of T3 in extent of primary tumor. No side effects were observed nor was there a significant difference between the control group and the PHA group in the 3-year crude survival rate (control group: 68.4%; PHA group: 62.5%)
    Notes: Zusammenfassung Behandlung von 24 Patienten mit einem Plattenepithelkarzinom der Kieferhöhle mit 50 μg Phytohaemagglutinin (PHA). Das Präparat wurde mittels Gelita in die peroral eröffnete Kieferhöhle eingebracht und die Therapie mit einer Telekobaltbestrahlung von 4000 rad (20×200 rad über einen Monat) sowie arteriellen Infusionen von 5-Fluorouracil (5-FU), 20×250 mg, kombiniert. Nach 20 Behandlungen mit PHA war der Tumor in 83,3% der Fälle verschwunden, während er bei den Patienten ohne PHA-Therapie nur in 62,6% nicht mehr nachzuweisen war. Bei der histologischen Untersuchung fand sich in der PHA-Gruppe in 66,6% kein Tumor mehr, bei der Gruppe ohne PHA dagegen nur in 15,8%. Nebenwirkungen wurden nicht beobachtet. In der 3 Jahre-Überlebensrate bestand zwischen beiden Gruppen kein signifikanter Unterschied.
    Type of Medium: Electronic Resource
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