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  • 1995-1999  (9)
  • 1980-1984  (7)
  • 1940-1944
  • 1998  (9)
  • 1980  (7)
  • 1
    Electronic Resource
    Electronic Resource
    Distribution and Developmental Regulation of Metabotropic Glutamate Receptor 7a in Rat Brain (1998)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 71 (1998), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: To determine the regional and cellular distribution of the metabotropic glutamate receptor mGluR7a, we used rabbit anti-peptide polyclonal-targeted antibodies against the C-terminal domain of mGluR7a. Here we report that immunocytochemistry at the light-microscopic level revealed that mGluR7a is widely distributed throughout the adult rat brain, with a high level of expression in sensory areas, such as piriform cortex, superior colliculus, and dorsal cochlear nucleus. In most brain structures, mGluR7a immunoreactivity is characterized by staining of puncta and fibers. However, in some regions, including the locus ceruleus, cerebellum, and thalamic nuclei, both cell bodies and fibers are immunopositive. The changes in levels of mGluR7a during development were investigated with immunoblotting and immunocytochemical analysis. Immunoblot analysis revealed that the levels of mGluR7a are differentially regulated across brain regions during postnatal development. In cortical regions (hippocampus, neocortex, and olfactory cortex), mGluR7a levels were highest at postnatal day 7 (P7) and P14, then declined in older rats. In contrast, mGluR7a levels were highest at P7 in pons/medulla and cerebellum and decreased markedly between P7 and P14. In these regions, mGluR7a immunoreactivity was at similar low levels at P14 and P21 and in adults. Immunocytochemical analysis revealed that staining for mGluR7a was exceptionally high in fiber tracts in P7 animals relative to adults. Furthermore, the pattern of mGluR7a immunoreactivity in certain brain structures, including cerebellum, piriform cortex, and hippocampus, was significantly different in P7 and adult animals. In summary, these data suggest that mGluR7a is widely distributed throughout the rat brain and that this receptor undergoes a dynamic, regionally specific regulation during postnatal development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1998.71020636.x
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  • 2
    Electronic Resource
    Electronic Resource
    Lingual nerve injury associated with laryngeal mask use (1998)
    Oxford : Blackwell Science Ltd
    Anaesthesia 53 (1998), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1998.537d-az0584d.x
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  • 3
    Electronic Resource
    Electronic Resource
    RNA LOCALIZATION IN DEVELOPMENT (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 67 (1998), S. 335-394 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract Cytoplasmic RNA localization is an evolutionarily ancient mechanism for producing cellular asymmetries. This review considers RNA localization in the context of animal development. Both mRNAs and non-protein-coding RNAs are localized in Drosophila, Xenopus, ascidian, zebrafish, and echinoderm oocytes and embryos, as well as in a variety of developing and differentiated polarized cells from yeast to mammals. Mechanisms used to transport and anchor RNAs in the cytoplasm include vectorial transport out of the nucleus, directed cytoplasmic transport in association with the cytoskeleton, and local entrapment at particular cytoplasmic sites. The majority of localized RNAs are targeted to particular cytoplasmic regions by cis-acting RNA elements; in mRNAs these are almost always in the 3'-untranslated region (UTR). A variety of trans-acting factors-many of them RNA-binding proteins-function in localization. Developmental functions of RNA localization have been defined in Xenopus, Drosophila, and Saccharomyces cerevisiae. In Drosophila, localized RNAs program the antero-posterior and dorso-ventral axes of the oocyte and embryo. In Xenopus, localized RNAs may function in mesoderm induction as well as in dorso-ventral axis specification. Localized RNAs also program asymmetric cell fates during Drosophila neurogenesis and yeast budding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biochem.67.1.335
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  • 4
    Electronic Resource
    Electronic Resource
    NaCl-induced accumulation of glycinebetaine in four subtropical halophytes from Pakistan (1998)
    Copenhagen : Munksgaard International Publishers
    Physiologia plantarum 102 (1998), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Variation in both the total content and the concentration of glycinebetaine in response to increasing soil salinity was studied in the salt-secreting Atriplex griffithii Moq., the leaf succulent Suaeda fruticosa (L.) Forssk., the stem succulent Haloxylon recurvum Bunge ex Boiss. and the osmotically adjusting desert grass Halopyrum mucronatum (L.) Stapf. collected from a subtropical maritime desert in Pakistan. Glycinebetaine content (mmol kg−1 dry weight) increased with increasing NaCl in Atriplex griffithii, Haloxylon recurvum and Halopyrum mucronatum, but peaked at 600 mM NaCl for Suaeda fruticosa and declined thereafter. Glycinebetaine concentration (mmol l−1 tissue water) increased with increasing salinity in all four halophyte species and was sufficiently high to serve as an osmoticum in all cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1399-3054.1998.1020402.x
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  • 5
    Electronic Resource
    Electronic Resource
    Unusual presentation of acute ocular toxoplasmosis (1980)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 215 (1980), S. 53-58 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwei ungewöhnliche Fälle von oculärer Toxoplasmose werden dargestellt. Eine 24jährige Patientin entwickelte retinale Gefäßneubildungen und Papillenproliferationen in Zusammenhang mit einer akuten oculären Toxoplasmose. Mit Rückbildung der Entzündung gingen die Neovaskularisationen ebenfalls zurück. Retinale Ischämie oder die Entzündung allein werden als mögliche kausale Ursache diskutiert. Eine 19jährige Patientin entwickelte ein Ödem des Nervus opticus und eine erhebliche Visusherabsetzung in Zusammenhang mit einem Toxoplasmoseherd im nasalen Quadranten der Netzhaut mit einer Sternfigur in der Macula. Bei Rückbildung des Prozesses entwickelte sich eine Opticusatrophie; das Sehvermögen normalisierte sich jedoch. Ödeme des Nervus opticus und Opticusatrophie werden als Folge einer diffusen und nicht einer fokalen Entzündung des Nervus opticus durch den Erreger angesehen.
    Notes: Abstract Two unusual cases of ocular toxoplasmosis are presented. A 24 year old woman developed retinal and optic nerve neovascularization in conjunction with acute ocular toxoplasmosis. The neovascularization regressed with resolution of the inflammation. The possibility of retinal ischemia or inflammation alone as an etiology are discussed. A 19 year old woman developed optic nerve edema and a marked decrease in vision associated with a nasal toxoplasma lesion and a macular star. With resolution of the process, optic atrophy developed but visual acuity returned to normal. Optic nerve edema and atrophy were felt to result from diffuse inflammation, but not from focal involvement in the nerve itself with the organism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413396
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  • 6
    Electronic Resource
    Electronic Resource
    Case report 122 (1980)
    Springer
    Skeletal radiology 5 (1980), S. 189-192 
    Details
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347264
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  • 7
    Electronic Resource
    Electronic Resource
    Classic adamantinoma in a 3-year-old (1998)
    Springer
    Skeletal radiology 27 (1998), S. 406-409 
    Details
    ISSN: 1432-2161
    Keywords: Key words Adamantinoma ; Classic ; Tibia ; Child
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Classic adamantinoma of the long bones is a rare, low-grade malignant neoplasm arising most often in the tibia and usually in patients during the second to fifth decades. Although adamantinomas have been described in children, the histologic pattern in this age group is different from that seen in adults and resembles osteofibrous dysplasia. The usual pattern of adamantinoma in children has been termed “differentiated adamantinoma” and follows a benign course. We report a case of adamantinoma in the proximal tibia of a 3-year-old patient. The lesion had abundant epithelial component with formation of keratin pearls, a pattern that has been described only in classic adamantinoma occurring in adults. Since differentiated adamantinomas are essentialy benign and classic adamantinomas are low-grade malignancies, the finding of a classic variant at this young age raised important therapeutic and prognostic issues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050409
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  • 8
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    The Conventions of Classical Satire and the Practice of Pope (1980)
    Iowa City : Periodicals Archive Online (PAO)
    Philological Quarterly. 59:3 (1980:Summer) 317 
    Details
    ISSN: 0031-7977
    Topics: Linguistics and Literary Studies , Classical Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1180-1980-059-03-000005
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  • 9
    Electronic Resource
    Electronic Resource
    Tomudex (ZD1694, NSC 639186) in platinum-pretreated recurrent epithelial ovarian cancer: a phase II study by the Gynecologic Oncology Group (1998)
    Springer
    Cancer chemotherapy and pharmacology 42 (1998), S. 68-70 
    Details
    ISSN: 1432-0843
    Keywords: Key words Thymidylate synthase ; Antifolates ; MOv18 antibody ; Cisplatin-sensitive ovarian cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Tomudex is a second-generation folate analogue that when polyglutamated is a potent inhibitor of thymidylate synthase (TS). Methods: Based on indications of antitumor activity in phase I trials, the Gynecologic Oncology Group initiated a phase II study of Tomudex 3 mg/m2 intravenously every 3 weeks in patients with epithelial ovarian cancer, who had been pretreated with platinum drugs, and had subsequently recurred more than 6 months following such treatment. Results: Of 30 patients entered into the trial, 2 were pathologically ineligible, leaving 28 fully evaluable. In this patient population, Tomudex was generally well tolerated, but only three objective (partial) responses were documented. Conclusions: With the level of activity seen, the drug was not considered for further clinical development in ovarian cancer by the Gynecologic Oncology Group. However, it may be worthwhile to explore whether quantitation of TS could lead to selection of patients more likely to respond to this TS inhibitor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050786
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  • 10
    Electronic Resource
    Electronic Resource
    Chondrosarcoma of the short tubular bones of the hands and feet (1998)
    Springer
    Skeletal radiology 27 (1998), S. 625-632 
    Details
    ISSN: 1432-2161
    Keywords: Key words Chondrosarcoma ; Enchondroma ; Enchondromatosis ; Hand ; Foot ; Radiology ; Pathology ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. To report 12 cases of chondrosarcoma in a rare location, the short tubular bones of the hands and feet, as well as 12 cases of enchondroma in similar locations, emphasizing the radiologic and histopathologic features. Design and patients. All relevant cases that had both histologic slides and radiographs available were taken from the files of one orthopedic referral hospital and the personal files of one of the authors. A similar number of enchondroma cases was selected at random from the files. Results and conclusions. One malignancy arose in a background of enchondromatosis, with all the others being solitary lesions. A pathologic diagnosis of malignancy is often difficult in the absence of radiologic signs of malignancy (cortical destruction with or without soft tissue extension). However, three cases were unusual in that the initial radiograph demonstrated a benign appearance. Another group of three malignancies was surprisingly indolent biologically. The treatment of choice is ray resection (or more limited amputation in a lesion of the middle or distal phalanx).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050448
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