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  • 1995-1999  (2)
  • 1980-1984  (1)
  • 1995  (2)
  • 1981  (1)
  • Alectra vogelii  (1)
  • Double-blind  (1)
  • clonidine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A clinical and pharmacodynamic evaluation of sulpiride (1981)
    Springer
    Psychopharmacology 73 (1981), S. 77-80 
    Details
    ISSN: 1432-2072
    Keywords: Double-blind ; Sulpiride ; Haloperidol ; Chronic schizophrenia ; Drug concentration ; Prolactin level ; Clinical effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind study the therapeutic efficacy of sulpiride was compared to that of haloperidol — an established neuroleptic agent. A total of 30 female patients with a diagnosis of chronic schizophrenia were initially stabilised on the dosage of haloperidol which produced optimum therapeutic response when given once or twice daily. The patients were then randomly allocated to receive either sulpiride or haloperidol over a period of 12 weeks. Plasma drug concentrations and prolactin levels were determined. Clinical effects were evaluated by Brief Psychiatric Rating Scale (BPRS), Wing Rating Scale, and Extrapyramidal Symptoms Rating Scale (EPS). A standardised side-effects checklist was used. Treatment with sulpiride was associated with a significant rise in plasma prolactin level, but paradoxically these patients had significantly reduced extrapyramidal symptoms. No significant correlation was found between plasma sulpiride concentration and prolactin level or any of the clinical variables. The study confirms the antipsychotic activity of sulpiride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431106
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The effects of clonidine on cardiovascular responses to standing in healthy volunteers (1995)
    Springer
    Clinical autonomic research 5 (1995), S. 171-177 
    Details
    ISSN: 1619-1560
    Keywords: clonidine ; sympathetic nervous system ; blood pressure monitoring ; hypotension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study assessed the effects of clonidine on blood pressure (BP) and heart rate responses to active standing, recorded continuously using a Finapres monitor. Ten subjects were given a placebo infusion over 1 h, followed by clonidine hydrochloride 1.5 µg/kg over 2 h. During placebo and at 1, 3 and 19 h following the clonidine infusion, heart rate and blood pressure were recorded during the second half of supine rest for 10 min, active standing and quiet standing for 7 min. Clonidine did not alter the size of immediate drop in BP on standing, although the nadir was lower. BP recovery was impaired, with a loss of the usual BP overshoot in most subjects and with delays in reaching supine levels of diastolic BP (6.1 versus 9.6 s; p 〈 0.01) and systolic BP (8.1 versus 12.3 s; p 〈 0.05). The compensatory initial heart rate rise was significantly increased from 47 to 53 beats/min (p 〈 0.05), athough the peak rate reached was reduced from 114 to 104 beats/min (p 〈 0.05). These results demonstrate that impairment of central sympathetic vasomotor drive leads to a delay in BP recovery and loss of initial BP overshoot immediately after standing, together with impaired maintenance of early steady-state BP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01826201
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    New sources of resistance of cowpea (Vigna unguiculata) toStriga gesnerioides, a parasitic angiosperm (1995)
    Springer
    Euphytica 84 (1995), S. 165-174 
    Details
    ISSN: 1573-5060
    Keywords: Alectra vogelii ; cowpea propagation ; field trials ; in vitro screen ; resistance mechanisms ; Striga gesnerioides ; Vigna unguiculata (cowpea)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Thirty-seven accessions of cowpea and yard-long bean were assessed for resistance toStriga gesnerioides. Cowpea plants were grown using anin vitro method, then inoculated with young seedlings ofS. gesnerioides produced from seed from three West African countries. Resistance was assessed by comparing the number and size ofS. gesnerioides tubercles on these accessions with those on a known susceptible cowpea, cv. Blackeye. Two cowpea landraces, APL-1 and 87-2, were completely resistant toS. gesnerioides from Burkina Faso, Mali and Cameroon and partially resistant toS. gesnerioides from Niger. Complete resistance was expressed either as a hypersensitive response of infected root tissues or as a severely retarded development of successful infections. All other accessions, including three samples of yard-long bean were susceptible toS. gesnerioides. The original 87-2 plants segregated for resistance and susceptibility. However, uniformly resistant progeny were obtained by producing seed from vegetatively propagated clones of single resistant 87-2 plants. Resistance of APL-1 and 87-2 toS. gesnerioides was confirmed in pot and field trials. Neither of these cowpeas were resistant toAlectra vogelii. Varieties APL-1 and 87-2 provide additional sources of resistance to most races ofS. gesnerioides, including a newly discovered virulent race from Benin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01681808
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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