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  • 1980-1984  (2)
  • 1983  (2)
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  • 1980-1984  (2)
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  • 1
    ISSN: 1432-1440
    Keywords: Acute leukaemia ; Infection prophylaxis ; Selective decontamination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective study the efficacy of two regimens for selective decontamination of the digestive tract was studied in patients with acute leukaemia during remission induction therapy. Seventy-eight patients were randomized to receive either a combination of cotrimoxazole, polymyxin B and nystatin (group A) or a combination of nalidixic acid, polymyxin B, neomycin and nystatin. With both regimens the gastrointestinal tract could be decontaminated equally effectively from potential pathogens. In the oropharyngeal region the decontamination from Enterobacteriaceae was significantly better in group A (P〈0.01). In both groups less than 10% of the acquired infections were caused by gram-negative bacilli and no gram-negative septicaemia occurred in either group. The median time interval until the first acquired infection was 17 days in group A and 36 days in group B, respectively (P〈0.05). It is concluded that regimen A might be more effective than regimen B though both regimens prevent reliably severe gram-negative infections.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Infection 11 (1983), S. 170-172 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An zwei Kasuistiken von Mucormykose bei Patienten mit akuten Leukämien werden die typischen Symptome und Verläufe dieser Infektion bei infektabwehrgeschwächten Patienten dargestellt. Bei diesen Patienten tritt vorwiegend die pulmonale oder disseminierte Form der Mucormykose auf, die meist rasch tödlich verläuft. Die Diagnose ist schwierig, da ein mikrobiologischer Nachweis aus Sputum oder Blut nur selten gelingt. Der Verdacht auf das Vorliegen einer Mucormykose oder einer anderen Pilzinfektion sollte insbesondere dann aufkommen, wenn bei einem Patienten mit einer Abwehrschwäche eine Infektion auf eine adäquate antibiotische Therapie nicht anspricht.
    Notes: Summary We are presenting two typical case histories of mucormycosis in patients with acute leukaemia which illustrate some of the important features of this infection in compromised hosts. In such patients, mucormycosis is mostly pulmonary or widely disseminated and often has a rapidly fatal course. A microbiological diagnosis from blood or sputum is difficult to establish. Mucormycosis or other fungal infections should be suspected in compromised patients with infections which do not respond to adequate antibiotic therapy.
    Type of Medium: Electronic Resource
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