ISSN:
1432-0533
Keywords:
Synaptic density
;
Phenylketonuria
;
Phenylacetate neurotoxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In experimental phenylketonuria, induced in the rat by exposure to phenylacetate during the first 21 days of life, there was a significant reduction of boutons, a decrease of an average of 25% in the whole cerebellar molecular layer. Both the density of synaptic profiles per square unit and the number of synapses per unit volume were decreased in the phenylacetatetreated rat as compared to the age-matched control. Neuronal density was unaffected. Results are interpreted to show a deficit of synapses per neuron, probably due to a decrease in synaptic formation in phenylacetate-induced phenylketonuria. Undernutrition was eliminated as a contributing factor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00692004
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