ISSN:
0025-116X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
The macrolactonization of ω-bromocarboxylic acids was carried out in the presence of polystyrene-supported 1,8-diazabicyclo[5.4.0]undec-7-ene. The macrolide yield was found to be a function of the degree of ring substitution and of crosslinking, which governs the effective concentration of the fixed substrate within the polymeric reagent. The effect of the polystyrene matrix on the macrolide yield in the heterogeneous system was discussed by comparison with the corresponding homogeneous reaction.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/macp.1985.021861207
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