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  • 1
    Electronic Resource
    Electronic Resource
    Ozone exposure suppresses epithelium-dependent relaxation in feline airway (1995)
    Springer
    Lung 173 (1995), S. 47-56 
    Details
    ISSN: 1432-1750
    Keywords: Airway hyperresponsiveness ; Ozone ; Airway epithelial cell ; Bronchiole ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the effect of exposure to ozone on the epithelium-dependent relaxation (EpDR) of bronchioles evoked by electrical field stimulation (EFS) in a feline model with hyperresponsive airways induced by exposure to ozone. Airway responsiveness was assessed by measuring the increases in total pulmonary resistance (RL) produced by aerosolized acetylcholine (ACh) in vivo. Airway responsiveness was also measured in vitro in dissected bronchiolar ring preparations. Exposure to ozone (3 ppm, 2 h) significantly increased the airway responsiveness in vivo. The concentration of ACh required increasing R L to 200% of the baseline value, decreased from 1.97 mg/ml (GSEM 1.94) to 0.12 mg/ml (GSEM 1.77, p 〈 0.01) after exposure to ozone. EFS evoked atropine-, guanethidine-, and tetrodotoxin-resistant relaxations in the control bronchiolar rings precontracted by 5-hydroxytryptamine. Such relaxation was significantly suppressed by the mechanical denudation of epithelium, confirming that it was epithelium dependent. The amplitude of EpDR was significantly suppressed in the animals exposed to ozone. These results suggest that EpDR is present in cats, and that its inhibition may contribute to the development of airway hyperresponsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167600
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  • 2
    Electronic Resource
    Electronic Resource
    High level radioactive nuclides in Japan in May (1986)
    [s.l.] : Nature Publishing Group
    Nature 321 (1986), S. 819-820 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-The accidental release of radioactive materials from the Chernobyl nuclear power plant on 26 April 1986 is known to have caused significant pollution in Western Europe at distances as great as 2,000 km. We have been measuring natural and artificial radionuclides in the environment of Japan for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/321819a0
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  • 3
    Electronic Resource
    Electronic Resource
    Gravitationally redshifted emission implying an accretion disk and massive black hole in the active galaxy MCG63015 (1995)
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 659-661 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recent optical and radio observations2 4 of gas motions show a large, central concentration of mass (probably a black hole) in a number of galaxies. But this gas lies beyond ~30,000 Schwarzschild radii so the characteristic signatures of the black hole itself-relativistic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/375659a0
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  • 4
    Electronic Resource
    Electronic Resource
    Specific determination of arylsulfatase A activity (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 33-35 
    Details
    ISSN: 1420-9071
    Keywords: Arylsulfatase A ; natural substrate ; ascorbate-2-sulfate ; HPLC-amperometric detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Arylsulfatase activities in biological materials are too low to be detected by the methods available hitherto. A sensitive and specific assay method for arylsulfatase A (AS-A) has been developed in the present study. Ascorbate-2-sulfate is known to be a specific natural substrate of AS-A; the ascorbic acid liberated by the action of AS-A was quantitatively determined using HPLC equipped with an amperometric detector. The method was used to analyze the activity of AS-A in biological materials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975881
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  • 5
    Electronic Resource
    Electronic Resource
    Involvement of substance P as a mediator in capsaicin-induced mouse ear oedema (1995)
    Springer
    Inflammation research 44 (1995), S. 470-474 
    Details
    ISSN: 1420-908X
    Keywords: Mouse ear oedema ; Capsaicin ; Tachyphylaxis ; Substance P ; NK1 receptor antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the involvement of substance P (SP) in mouse ear oedema induced by topical application of capsaicin (250 µg/ear). Reapplication of capsaicin at 4h, 24h, and 48h after initial treatment did not induce a second oedema response. Oedema induced after the second application was significantly (p〈0.01 orp〈0.001) suppressed for up to 30 days but was observed when capsaicin was applied 40 days after initial treatment. Topical pretreatment of ears with capsaicin at 4h, 24h and 48h before i.v. injection of SP (5 µg/kg) did not cause a significant inhibition of plasma extravasation in ear skin. NK1 receptor antagonists such as RP 67580 (ED50:0.19 mg/kg, i.v.), spantide II (ED50:0.33 mg/kg, i.v.), and GR 82334 (ED50:0.26 mg/kg, i.v.), inhibited capsaicin-induced ear oedema, whereas SR 48968 (2.0 mg/kg, i.v.), a NK2 receptor antagonist, had no effect. Furthermore, RP 67580 (0.5 kg/mg, i.v.) inhibited the oedema response induced by reapplication of capsaicin at 50 days after initial treatment. These results indicate that tachyphylaxis of capsaicin-induced oedema is reversible and suggest that this response may be due mainly to a reduction of SP in sensory neurones but not to any loss of responsiveness of NK1 receptors. We also conclude that SP and NK1 receptors are involved predominantly in the development of capsaicin-induced mouse ear oedema.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01837912
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical pathology of primitive gliomas in the cerebrum (1986)
    Springer
    Acta neurochirurgica 81 (1986), S. 94-99 
    Details
    ISSN: 0942-0940
    Keywords: Primitive glioma ; ependymoblastoma ; undifferentiated glioma ; unclassified glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the biological features of primitive gliomas in the cerebrum and clearly distinguish them from malignant or anaplastic gliomas and glioblastomas, we studied eight cases clinically and pathologically. Our evaluations included immunohistochemical and electron microscopic observations. We divided the patients into two groups, children and young adults. Most tumours appeared as ring-like, enhanced masses on computed tomography and avascular or ring-like, vascular masses on angiography. Macroscopically, the tumours were well demarcated and contained cysts. Ocassionally we found tumour dissemination. Microscopically, the tumours were composed of small, round cells without remarkable structural features. Ependymal, astroglial, and oligodendroglial differentiation was evident, in varying proportions; tumours in which the differentiated areas constituted more than half of the mass were classified as poorly differentiated gliomas. By these criteria, this series comprised four undifferentiated and four poorly differentiated gliomas. Cell anaplasia and polymorphism were rare in both undifferentiated and differentiated areas of the tumours. Immunohistochemical and electron microscopic examinations also revealed glial differentiation. These primitive gliomas appear to be biologically similar, but not identical, to cerebellar medulloblastomas. In this series, five patients died because of recurrence or dissemination. Whole brain and spinal irradiation should be considered after total or subtotal surgical removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401228
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  • 7
    Electronic Resource
    Electronic Resource
    A molecular dynamics-aided fracture mechanics parameter and its application to a tensile problem (1995)
    Springer
    Computational mechanics 16 (1995), S. 217-222 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  To evaluate fracture by a single parameter like J integral in molecular dynamics (MD) calculation, we propose a parameter derived by extending ĵ integral to atomic model, being referred to as H-sum. To examine the path independence of H, we first apply H to a simple tensile problem of two dimensional model of α-iron by using molecular dynamics method. As a result, we confirm that H has the path independence within an accuracy of 8.5. In addition, the validity of the proposed parameter is clarified by analyzing a problem of microscopic crack initiation and propagation process. H increases with increasing tensile stress and reaches a critical value when a crack initiates, and subsequently decreases with the crack growth. Calculating K IC from this critical H, we compare K IC with deCelis’and the Mullins’results calculated directly from MD calculation, and get good agreement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369866
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  • 8
    Electronic Resource
    Electronic Resource
    A molecular dynamics-aided fracture mechanics parameter and its application to a tensile problem (1995)
    Springer
    Computational mechanics 16 (1995), S. 217-222 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract To evaluate fracture by a single parameter like J integral in molecular dynamics (MD) calculation, we propose a parameter derived by extending Ĵ integral to atomic model, being referred to as H-sum. To examine the path independence of H, we first apply H to a simple tensile problem of two dimensional model of α-iron by using molecular dynamics method. As a result, we confirm that H has the path independence within an accuracy of 8.5%. In addition, the validity of the proposed parameter is clarified by analyzing a problem of microscopic crack initiation and propagation process. H increases with increasing tensile stress and reaches a critical value when a crack initiates, and subsequently decreases with the crack growth. Calculating K IC from this critical H, we compare K IC with deCelis' and the Mullins' results calculated directly from MD calculation, and get good agreement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369866
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  • 9
    Electronic Resource
    Electronic Resource
    Specific effect of magnesium ion on 2′, 3′-cyclic amp synthesis from adenosine and trimeta phosphate in aqueous solution (1995)
    Springer
    Origins of life and evolution of the biospheres 25 (1995), S. 47-52 
    Details
    ISSN: 1573-0875
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Notes: Abstract Phosphorylation of adenosine by trimetaphosphate was investigated using various catalysts in aqueous solution under mild conditions at pH ∼ 7.0 and at 41 °C. The product was primarily 2′,3′-cyclic AMP together with smaller amounts of ATP. Magnesium ion was found to have a remarkable catalytic effect of approximately one hundred times greater than the other chemicals tested. The mechanism for the specific effect of magnesium ion is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01581572
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of organic solvents on the activity of glucoamylase (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 28 (1986), S. 1172-1177 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Hydrolyses of maltose, maltotriose, and soluble starch catalyzed by glucoamylase (Asp. Niger) were carried out in the aqueous solutions of methanol, ethanol, ethylene glycol, and 1,4-dioxane at 40°C and at the optimum pH in the respective solutions. By the kinetic analysis based on the subsite model, it was shown that the intrinsic rate constant, Kint, was electrostatically affected by the dielectric constant of the hydroorganic solutions. The affinity of the third subsite, A3, which affects the apparent rate constant, K0, was correlated with the ×Gtr's of maltose and amino acid side chains.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260280807
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