Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1990-1994  (2)
  • 1985-1989  (1)
  • 1950-1954
  • 1990  (2)
  • 1988  (1)
Material
Years
  • 1990-1994  (2)
  • 1985-1989  (1)
  • 1950-1954
Year
  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fourteen three-generation families were identified in which a new mutation to NF-1 had occurred in a single individual in the second generation. DNA typing of these families for loci closely linked to NF-1 (results summarized in Table 1 and Fig. 1) showed that in 12 of the 14 cases, it was ...
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have investigated genetic linkage of von Recklinghausen neurofibromatosis (NF1) and achondroplasia (ACH) using chromosome-17 markers that are known to be linked to NF1. Physical proximity of the two loci was suggested by the report of a patient with mental retardation and the de novo occurrence of both NF1 and ACH. Since the chance of de novo occurrence of these two disorders in one individual is 1 in 600 million, this suggested a chromosomal deletion as a single unifying molecular event and also that the ACH and NF1 loci might be physically close. To test this, we performed linkage analysis on a three-generation family with ACH. We used seven DNA probes that are tightly linked to the NF1 locus, including DNA sequences that are known to flank the NF1 locus on the centromeric and telomeric side. We detected two recombinants between the ACH trait and markers flanking the NF1 locus. In one recombinant, the flanking markers themselves were nonrecombinant. Multi-point linkage analysis excluded the ACH locus from a region surrounding the NF1 locus that spans more than 15cM (lod score 〈 -2). Therefore, analysis of this ACH pedigree suggests that the ACH locus is not linked to the NF1 locus on chromosome 17.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 28 (1988), S. 298-303 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract An experimental method is described for measuring the dynamic initiation toughness of a sharp stationary crack. A plane specimen is utilized which consists of a central region 50-mm wide and 200-mm long with integral dog-bone ends. The loading is accomplished by the detonation of four small explosive charges which produce two tensile stress waves upon reflection from the dog-bone ends. The stress waves meet at the midpoint of the specimen and reinforce to produce a relatively large, uniformly stressed region with a very high loading rate. The crack is positioned at the midpoint of the specimen at the location where the reinforcing tensile stress waves meet. A series of photoelastic experiments were conducted using Homalite 100 as the model material to observe, in a full-field view, the arrival of the dilatational waves, the subsequent development of the stress field at the tip of the stationary crack and the initiation of the crack. The isochromatic fringe pattern was also used to determine the instantaneous value of the stress-intensity factorK(t) after the characteristic fringe loops developed in the region near the crack tip. Finally,K(t) was measured using a single strain gage positioned and oriented so that its signal output was proportional toK(t) and independent of the next two higher order terms in the series representation of the strain field. A method was developed to determine the instant of initiation from the strain-time trace. Results obtained from the photoelastic and strain measurements of the dynamic-initiation toughnessK ID were consistently higher than the static value ofK IC .
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...