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  • 1995-1999  (3)
  • 1985-1989  (5)
  • 1970-1974
  • 1997  (3)
  • 1988  (5)
  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 2743-2747 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The Raman spectra of hydrogen-bonded crystalline HCONH2 and HCOND2 have been measured up to 10 GPa at 300 K in a gasketed diamond anvil cell. The frequencies of the in-plane intermolecular stretching mode which characterizes the hydrogen bond along the zig–zag chain increase with increasing pressure with a slope (dν/dP) of 11.1 cm−1/GPa, and its slope becomes steeper, to 19.2 cm−1/GPa, at about 5.0 GPa (=Pc). The frequencies of the intramolecular ND2 stretching mode decrease with increasing pressure at all pressure range except around Pc where they show an increase of 20 cm−1. It turns out from these results that (1) the hydrogen (deuteron) bonds along the chain direction become stronger in response to the pressure, and their increasing strength are more developed above Pc, and (2) the other type of hydrogen (deuteron) bonds which bridge the chains to make their planar hydrogen-bonded network are weakened around Pc. The pressure-induced phase transition at Pc is discussed by focusing on the behavior of two types of hydrogen bondings and the effect of the interplanar interaction.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 4-year-old female mongrel dog with a history since birth of erosions and atrophic skin, with pigmentation and alopecia on the face, trunk and extremities, together with dystrophic nails. Light microscopy revealed subepidermal blisters with minimal inflammation and electron microscopy confirmed that the ultrastructural site of separation site was at the lamina lucida. Indirect immunofluorescence of the dog's skin detected the positive expression of laminin 5. BPAG2, integrinα6 and type VII collagen. These clinical, ultrastructural and immunohistochemical features suggested that the dog had a non-lethal subtype of junctional epidermolysis bullosa (JEB). This is the first confirmed case of non-lethal JEB in a dog and presents a possible candidate for an animal model of gene therapy. Further study should provide important information of the phenotype, pathophysiology and prognosis of non-lethal JEB in humans.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 119 (1988), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Using an immunoelectron microscopic technique we have compared the ulrastructural localization of IgG and complement (C3) in the basement membrane zone of three typical cases of bullous pemphigoid and three atypical variant cases (nodular, polymorphic and localized pemphigoid, respectively). There was no significant difference in the in vivo ultrastructural localization of these immunoreactants between the typical and the atypical cases of pemphigoid. In all cases IgG and C3 were detected between the basilar surface of the basal keratinocytes and the basal lamina. Moreover, the in vitro binding sites of circulating anti-basement membrane zone antibodies were identical in the case of nodular pemphigoid and a typical pemphigoid as control. We also observed that immunoreactants were not deposited beneath melanocytes.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1438-2199
    Keywords: Amino acids ; Imidazole compound ; Mercaptopyruvic acid ; Urocanic acid ; Histidine ; Mass spectrometry ; Paper electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary S-[2-Carboxy-1-(1H-imidazol-4-yl)ethyl]-3-mercaptopyruvic acid (I) was chemically synthesized in 15% yield by incubating a reaction mixture oftrans-urocanic acid and 3-fold excess of 3-mercaptopyruvic acid at 45°C for 6 days. The synthesized compound was characterized by fast-atom-bombardment mass spectrometry and high-voltage paper electrophoresis. CompoundI was identified with a product of an enzymatic reaction ofS-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]-l-cysteine (II) with rat liver homogenate in a phosphate buffer, pH 7.4. CompoundI was degraded toS-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]-3-mercaptolactic acid (III), a compound previously found in human urine [Kinuta et al. (1994) Biochem J 297: 475–478], by incubation with rat liver homogenate. From these results, we suggest that compoundI is a metabolic intermediate for the formation of compoundIII from compoundII. The present pathway follows a formation of compoundII fromS-[2-carboxy-1-(1H-imidazol-4-yl)ethyl] gluthathione [Kinuta et al. (1993) Biochim Biophys Acta 1157: 192–198], a proposed metabolite ofl-histidine.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-069X
    Keywords: Key words Laminin 5 ; GB3 ; Herlitz ; JEB
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 333 (1988), S. 404-404 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TANAKA ET AL. reply-First, we would like to correct the term "mantle array" in the summary of ref. 1 to crustal array. We originally used the term crustal array to distinguish the clear eCe-eNd array, but the term was changed in the editing of our manuscript. It was pointed out in ref. 1 that ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 11 (1988), S. 94-102 
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The possibility of quantitative AES analysis using the whole EN(E) spectrum was examined for Au—Cu alloy samples. The EN(E) spectrum was measured under ϕ = 0° (normal) incidence of 10 keV electrons for the Au-44 at% Cu sample, and under ϕ = 0°, 30°, and 45° incidence of 10 keV primary electrons for the Au-20 at% Cu sample. Those spectra were compared with spectra which were obtained by linear combination of pure Au and Cu spectra measured under the same experimental conditions.Both measured and synthesized spectra coincided very well in the energy region lower than 1000 eV, except the region of slow secondary electrons. The results indicate that energy distribution of backscattered electrons of the Au—Cu alloy can be estimated well by linear combinations of pure sample spectra. They also indicate that, by comparison of the shape of the measured EN(E) spectrum with the synthesized one, the surface composition of the Au—Cu alloy sample can be estimated with reasonable accuracy (several % error).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 199-201 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: High-pressure Raman spectra of liquid and solid thiophene C4H4S have been measured up to 100 kbar at 300 K in a gasketed diamond anvil cell. The pressure dependence of intramolecular and intermolecular vibrational modes revealed a solidification point at 6 kbar and a pressure-induced phase transition at 40 kbar. This solid-solid phase transition was identified as the III→IV phase transition by comparison with the intermolecular Raman spectra of the low-temperature solids at atmospheric pressure. The appearance of a dark-red modification of C4H4S, which is irreversibly formed at pressures above 80 kbar with laser irradiation, is discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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