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  • 2000-2004  (2)
  • 1985-1989  (4)
  • 1930-1934
  • 1900-1904
  • 2002  (2)
  • 1988  (4)
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  • 2000-2004  (2)
  • 1985-1989  (4)
  • 1930-1934
  • 1900-1904
Year
  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Alverine citrate has been used in the treatment of irritable bowel syndrome for many years.Aims : To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.Methods : One hundred and seven patients with irritable bowel syndrome were entered into this three-centre, double-blind, randomized, placebo-controlled, parallel group trial. The primary end-point was relief of abdominal pain indicated by improvement in the scores for severity and frequency. Secondary efficacy variables included scores for other clinical symptoms and for overall well-being.Results : The severity and frequency of abdominal pain improved in 66% and 68% of patients treated with alverine citrate vs. 58% and 69% of the placebo group, but these differences were not significant. The mean percentage reduction in the scores for abdominal pain from baseline to the final assessment, although greater in the alverine citrate group (43.7%) compared with the placebo group (33.3%), was not statistically significant.Conclusions : Alverine citrate is no better than placebo at relieving the symptoms of irritable bowel syndrome. Future trials should be designed to take into account the high and persistent placebo response seen in this condition.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 12 (2002), S. 0 
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Acclimatization to moderate high altitude accompanied by training at low altitude (living high–training low) has been shown to improve sea level endurance performance in accomplished, but not élite, runners. Whether élite athletes, who may be closer to the maximal structural and functional adaptive capacity of the respiratory (i.e. oxygen transport from environment to mitochondria) system, may achieve similar performance gains is unclear. To answer this question, we studied 14 élite men and eight élite women before and after 27 days of living at 2500 m while performing high-intensity training at 1250 m. The altitude sojourn began 1 week after the USA Track and Field National Championships, when the athletes were close to their season's fitness peak. Sea level 3000-m time trial performance was significantly improved by 1.1% (95% confidence limits 0.3–1.9%). One-third of the athletes achieved personal best times for the distance after the altitude training camp. The improvement in running performance was accompanied by a 3% improvement in maximal oxygen uptake (72.1 ± 1.5–74.4 ± 1.5 ml kg− 1 min− 1). Circulating erythropoietin levels were near double initial sea level values 20 h after ascent (8.5 ± 0.5–16.2 ± 1.0 IU ml−1). Soluble transferrin receptor levels were significantly elevated on the 19th day at altitude, confirming a stimulation of erythropoiesis (2.1 ± 0.7–2.5 ± 0.6 μ g ml-1). Hb concentration measured at sea level increased 1 g dl−1 over the course of the camp (13.3 ± 0.2–14.3 ± 0.2 g dl−1). We conclude that 4 weeks of acclimatization to moderate altitude, accompanied by high-intensity training at low altitude, improves sea level endurance performance even in élite runners. Both the mechanism and magnitude of the effect appear similar to that observed in less accomplished runners, even for athletes who may have achieved near maximal oxygen transport capacity for humans.
    Type of Medium: Electronic Resource
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  • 3
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    Unknown
    Washington, etc. : Periodicals Archive Online (PAO)
    Poet lore. 83:3 (1988:Fall) 26 
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 335 (1988), S. 21-22 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DURING the nineteenth century, the discovery and study of 'lost civilizations' gave great impetus to the development of archaeology. The surviving traces of such civilizations - whether in the Mycenaean and Minoan palaces of the Aegean, the frontier defences of the Roman Empire, the pyramids of the ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental and applied acarology 4 (1988), S. 265-276 
    ISSN: 1572-9702
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Factors inducing outbreaks of spider mites (Acari: Tetranychidae) following use of pyrethroid insecticides are reviewed. Differentials in direct toxicity between spider mites and phytoseiid (Acari: Phytoseiidae) predators provide one explanation. Wide variation exists between pyrethroids in their direct toxicity toTetranychus urticae. The acaricidal action of pyrethroids is largely controlled by the amount of irritancy or repellency induced by the respective chemicals. Laboratory assays for repellency reflect field results. Repellent activity induces spider-mite dispersal to either recolonise plants free of residues or leave the treated habitat. Pyrethroids may also affect reproduction and development rates. Residual activity is likely to vary, so limiting any general theory of spider-mite responses to pyrethroids. Variable responses to pyrethroids, strain variation and development of behavioural resistance also add complications to understanding outbreaks. Future research needs are identified.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of chemical ecology 14 (1988), S. 561-579 
    ISSN: 1573-1561
    Keywords: Creosote bush ; Larrea ; nordihydroguaiaretic acid ; grasshoppers ; monophagy ; Bootettix ; Ligurotettix ; Cibolacris ; Orthoptera ; Acrididae ; host selection ; feeding deterrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The host-selection behavior of three species of grasshopper feeding on creosote bush,Larrea tridentata, in southern California was investigated. The species wereBootettix argentatus, which is monophagous;Ligurotettix coquilletti, oligophagous; andCibolacris parviceps, polyphagous. The monophagous species is stimulated to bite by nordihydroguaiaretic acid (NDGA), a compound that is characteristic of the host plant and that may comprise up to 10% of the dry weight of the leaf. Host specificity ofB. argentatus is enhanced by deterrent responses to compounds present in the surface waxes of all non-host-plant species. Both the oligophagous and polyphagous species are deterred by NDGA at naturally occurring concentrations. Their association withLarrea is probably based on tolerance of the plant chemicals rather than on dependence on specific chemicals. Factors other than the chemistry of the plant probably also contribute to the specificity ofB. argentatus andL. coquilletti.
    Type of Medium: Electronic Resource
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