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  • 2000-2004
  • 1990-1994
  • 1985-1989  (2)
  • 1988  (2)
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  • 2000-2004
  • 1990-1994
  • 1985-1989  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    An immunohistological study of 66 ependymomas (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sixty-six ependymomas were examined immunohistologically to determine their distribution of glial fibrillary acidic proteins, S-100 protein and vimentin. The neoplasms were subdivided into four groups: (1) ependymomas from the cauda equina, predominantly of the myxopapillary type; (2) benign ependymomas; (3) malignant ependymomas; and (4) ependymoblastomas. Marked differences in antigen reactivity were observed between each group. The intensity of the reaction with the three antibodies was strongest in malignant ependymomas. Ependymomas from the cauda equina showed a patchy distribution of positivity for the three antigens in cells surrounding blood vessels but there was no staining of collagenous septa or the myxoid areas. In ependymoblastomas, the cells of the rosettes were negative for glial fibrillary acidic protein, but there was focal positivity for vimentin and S-100. Other areas showed tumour cells containing moderate amounts of vimentin and small amounts of S-100, and a few bands of filaments positive for glial fibrillary acidic protein. The cytogenetic and biological implications of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02060.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mononuclear cell infiltrate and HLA-DR expression in low grade astrocytomas (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 281-286 
    Details
    ISSN: 1432-0533
    Keywords: Astrocyte ; Macrophage ; Lymphocyte ; Major histocompatibility complex antigens ; Cellular immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Frozen samples from 23 low grade (grade I and II) astrocytomas were studied by means of a panel of monoclonal antibodies to macrophages, lymphocytes (and their subsets) and HLA-DR antigens. Macrophages were present in low to moderate numbers in 38%–86% of cases, the variance in figures depending on the antibody used. T lymphocytes, the majority of CD8 phenotype, were detected in low numbers in 78% of tumours. B lymphocytes were scanty in 22% (5/22) and totally absent in the remaining cases. HLA-DR antigen was expressed by tumour cells in 35% (6/17) of cases. These findings indicate that in some low grade astrocytomas there is a mononuclear cell infiltrate with macrophages and secondarily CD8+lymphocytes playing the major role. The significance of these findings remains speculative at present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687776
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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