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  • 1
    Electronic Resource
    Electronic Resource
    Molecular Characterization of an Ependymin Precursor from Goldfish Brain (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 52 (1989), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Ependymins are thought to be implicated in fundamental processes involved in plasticity of the goldfish CNS. Gas-phase sequencing of purified ependymins β and γ revealed that they share the same N-terminal sequence. Each sequence displays microheterogeneities at several positions. Based on the protein sequences obtained, we constructed synthetic oligonucleotides and used them as hybridization probes for screening cDNA libraries of goldfish brain. In this article we describe the full-length sequence of a mRNA encoding a precursor of ependymins. A cleavable signal sequence characteristic of secretory proteins is located at the N-terminal end, followed directly by the ependymin sequence. Also, two potential N-glycosylation sites were detected. A computer search revealed that ependymins form a novel family of unique proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1989.tb10932.x
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  • 2
    Electronic Resource
    Electronic Resource
    Pressure effect on quenching of perylene fluorescence by halonaphthalenes (1989)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 93 (1989), S. 466-468 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100338a089
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of the phosphorescence quantum yield of singlet molecular oxygen (1.DELTA.g) in five different solvents (1989)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 93 (1989), S. 4507-4511 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100348a024
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  • 4
    Electronic Resource
    Electronic Resource
    Significance of latent hyperthyroidism (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 543-550 
    Details
    ISSN: 1432-1440
    Keywords: Hyperthyroidism, latent ; TSH ; Circadian rhythm ; Pulsatile secretion ; Diagnostic methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In euthyroidism the circadian rhythm and pulsatility of TSH is well known. With regard to hyperthyroidism only very preliminary data were described. In this tudy we investigated the secretion pattern of the pituitary-thyroid axis hormones during 24 h in latent and overt hyperthyroidism and in euthyroidism with regard to common and different properties. Blood was obtained for 24 h at 10-min intervals. In euthyroidism we found intraindividually three overlapping patterns of TSH, which are different in amplitude and frequency and can be found interindividually, too. These patterns are equal to the circadian rhythm, pulsatile secretion and lastly to the methodic rustle. The circadian rhythm in latent hyperthyroidism is distinctly suppressed and in overt hyperthyroidism totally. Whereas in latent hyperthyroidism pulsatile secretion is extant, in overt hyperthyroidism the TSH pulses are absent. To record the patients' TSH circadian rhythm with only three blood samples, we defined the TSH-Triplex. In young as well as in elderly healthy volunteers it demonstrated significantly higher TSH levels at midnight (at 24:00 h) than it did at 4 p.m. and 8 a.m. The present study shows a significantly different TSH pattern in latent hyperthyroidism compared to euthyroidism. It should be discussed whether latent hyperthyroidism could be defined as hyperthyroidism stage I. On the other hand, latent hyperthyroidism could be an illness with its own cause, different from hyperthyroidism. Our data suggest that the laboratory findings of latent hyperthyroidism in each age are non-physiological. However, the cause for this disorder is unclear until now; hence further investigations are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719781
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  • 5
    Electronic Resource
    Electronic Resource
    Book reviews (1989)
    Springer
    Annals of hematology 58 (1989), S. 254-254 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320914
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  • 6
    Electronic Resource
    Electronic Resource
    Sensitization of articular afferents to mechanical stimuli by bradykinin (1989)
    Springer
    Pflügers Archiv 415 (1989), S. 330-335 
    Details
    ISSN: 1432-2013
    Keywords: Joint afferents ; Sensitization ; Mechanosensitivity ; Bradykinin ; Prostaglandin E2 ; Articular nociception ; Joint pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 18 cats anaesthetized with alpha-chloralose, we recorded from thin myelinated and unmyelinated articular afferents of the medial articular nerve of the knee joint. Bradykinin was injected intra-arterially close to the knee, alone and in combination with prostaglandin E2 (PGE2), and changes of the responses of single afferents to movements of the knee were monitored. Bradykinin changed the mechanosensitivity in 20 of 28 afferents inducing movement sensitivity in initially unresponsive units, lowering the threshold for movements in high-threshold afferents and/ or enhancing pre-existing responses to innocuous and/or noxious joint movements in low and high threshold units. Also the application of PGE2 and bradykinin within a short interval sensitized the majority of these afferents, and in about 50% of the afferents the effect of the combination was superior to those induced by the single substances. We conclude that the inflammatory mediator bradykinin is able to sensitize articular afferents for movement stimuli and that PGE2 may enhance this effect. It is suggested that in arthritis inflammatory mediators act synergistically in the initiation and stabilization of the increased mechanosensitivity of slowly conducting articular afferents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370884
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  • 7
    Electronic Resource
    Electronic Resource
    Biological assays for irritant, tumor-initiating and tumor-promoting activities (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 516-524 
    Details
    ISSN: 1432-1335
    Keywords: 7,12-Dimethylbenz[a]anthracene ; Semiquantitative estimation of initiating activity ; Semiquantitative estimation of promoting activity ; Phorbol ester ; 12-O-tetradecanoylphorbol 13-acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A versatile standardized protocol of initiation/promotion of skin is described using 7,12-dimethylbenz[a]anthracene as initiator and diterpene esters as promoters in 28 female NMRI mice per promoter (or initiator) dose group including appropriate positive and negative controls (“standardized initiation/promotion protocol 28” or “protocol 28”). To monitor the weekly tumor responses, the tumor rate T r and the tumor yield T y were recorded per dose group collectively as a measure of the tumor-promoting (or initiating) activity of individual compounds; similarly the general health status of the group was controlled twice weekly by collective weighing of the dose group and recorded daily by the survival rate S r. Synoptic consideration of T r, T y and the promoter dose (or initiator dose) at a set time period of exposure was used for the semiquantitative estimation of the relative tumor-promoting (or initiating) potency, referring to a high-potency promoter (or initiator) as standard. The full scope of utilization of “protocol 28” to determine comparable individual promoting activities and-at 24 weeks of exposure — relative tumor-promoting potencies (rtpp 24) is demonstrated in typical examples with 12-O-tetradecanoylphorbol 13-acetate (TPA) as well as various other phorbol esters as promoters. For estimation of promoting potencies TPA is rated a rtpp24 of ++++. The other phorbol derivatives exhibit rtpp24 between 0 and ++++. In this manner, “protocol 28” was verified in 1000 promoter dose groups (i.e. 28 000 mice) to determine tumor-promoting activities of individual diterpene esters and partly also their rtpp24. Grading of tumor-promoting potencies of diterpene esters in skin by rtpp24 proved useful for evaluating the relative environmental risk involved in exposure to various diterpene esters as well as in comparative mechanistic investigations including structure/activity relationships. As an example, the correlation of irritancy and tumor-promoting potency of certain diterpene esters in epithelial tissue, postulated previously from essentially qualitative data, is verified in semiquantitative terms by comparison — as a typical example — of the irritancy of phorbol esters on the ear and of the corresponding rtpp24 on the back skin of NMRI mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391351
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  • 8
    Electronic Resource
    Electronic Resource
    Ellipsometrical measurements on porous copper films (1989)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 333 (1989), S. 410-412 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Porous films are prepared by depositing copper onto glass substrates at 77 K. The structure of the films is characterized ellipsometrically (λ=632.8 nm) and by means of resistivity measurements. The measured dielectric function of the porous films isɛ=−6.5 −4.6i, a value which deviates strongly from the corresponding value of bulk copper (ɛ m=−18 −1.6i). A quantitative evaluation on the basis of the EMA theory yields a void concentration of about 20%. In addition, the interaction of the films with oxygen is investigated. The gas tends to penetrate into the near-surface portion of the voids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572339
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  • 9
    Electronic Resource
    Electronic Resource
    Results of EEG mapping in senile dementia of Alzheimer's typ (SDAT) and vascular dementia (VD) (1989)
    Springer
    Journal of neural transmission 1 (1989), S. 28-28 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02312208
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  • 10
    Electronic Resource
    Electronic Resource
    Peroxofluorokomplexe der Übergangsmetalle. IX. Kristallstruktur von Ba3[Ti(O2)F5]2 · 2 H2OProfessor Walter Rüdorff in memoriam (1989)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 575 (1989), S. 197-201 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Transition Metal Peroxofluoro Complexes. IX. Crystal Structure of Ba3[Ti(O2)F5]2 · 2 H2OThe pale yellow hydrat Ba3[Ti(O2)F5]2 · 2 H2O crystallizes tetragonal (space group P42/mbc, a = 1 248.5(3), c = 812.2(2) pm; Z = 4; R = 0.026 for 404 independent reflections). It contains isolated [Ti(O2)F5]3- anions. Thermal decomposition leads directly to α-Ba3Ti2O2F10, which is isotypic to α-Ba3Al2F12.
    Notes: Das hellgelbe Hydrat Ba3[Ti(O2)F5]2 · 2 H2O kristallisiert tetragonal (Raumgruppe P42/mbc, a = 1 248,5(3), c = 812,2(2) pm; Z = 4; R = 0,026 für 404 unabhängige Reflexe) und enthält isolierte [Ti(O2)F5]3--Anionen. Die thermische Zersetzung führt direkt zum α-Ba3Ti2O2F10, das isotyp zum α-Ba3Al2F12 kristallisiert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19895750123
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