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  • 1985-1989  (3)
  • 1989  (3)
  • 1
    Electronic Resource
    Electronic Resource
    One-year MR imaging follow-up of patients with multiple sclerosis under cortisone therapy (1989)
    Springer
    Neuroradiology 31 (1989), S. 3-7 
    Details
    ISSN: 1432-1920
    Keywords: MRJ ; MS ; Follow up ; Drug therapie ; Cortisone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty patients with relapsing/remitting course of MS were studied four times with MR imaging over the course of one year. First MR was undertaken during the acute relapse, afterwards patients were given cortisone therapy for four to six weeks. The second MR study followed 4–6 weeks after the first, the patients at this time being in remission. The third MR study was carried out 4 months after the first, the last scan one year after the first. The total number of lesions varied, though not greatly, over the whole follow-up, but there was an influence of the clinical course of MS on the pattern of lesions in MR imaging, mostly in respect to the number of confluences and the size of the lesions. Follow-up over one year showed that the inflammatory process produced an increase in the number of plaques, independent of the fact that most patients stayed in remission. A delayed effect of the cortisone therapy on the size, number, and confluence of plaques is suggested whilst clinical signs improved in most cases immediately after the beginning of drug therapy. Independent of the clinical course of the disease in some cases plaques previously seen vanished and others appeared in one and the same examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342020
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  • 2
    Electronic Resource
    Electronic Resource
    Struktur-Reaktivitäts-Beziehungen bei koordinativ-ungesättigten Chelatkomplexen. XIX. Mitt.: JÄGER, E.-G.; BRUSBERG, J.; ULLRICH, R.; RICHTER, B.; HOFFMANN, R.; FRANKE, G.; BRÄNLICH, G.; GRÄFE, F.: Z. anorg. allg. Chem. (Manuskript eingereicht)., Einfluß des Zentralatoms und der Ligandstruktur auf die Massenspektrometrische Fragmentierung von Chelatkomplexen makrocyclischer und offenkettiger Schiffscher Basen (1989)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 331 (1989), S. 559-572 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Structure Reactivity Correlations on Coordinatively Unsaturated Metal Chelate Complexes. XI. Effect of the Central Atom and the Ligands on the Mass Spectrometric Fragmentation of Chelate Complexes with Macrocyclic and Open Chain Schiff Base LigandsThe influence of the central atom on the mass spectrometric fragmentation of the compounds 1-5 is compared. Whereas the ligands (Mt = 2H) show a strong fragmentation with a farreaching cleavage, the metal complexes with exception of Cu-4 and Cu-5 show always the molecular ion signal as the base peak. The main fragmentions [M-C2H5O]⊕, [M-2(C2H5O)]2⊕, [M-C2H4]⊕., and [M-C2H4CO2]⊕. may be related to the ‘cyclidene’ structures 6-7, the carboxylic acid 8, and its decarboxylation product 9. In the case of the copper chelates 1-4 the fragment [M-C2H6O].⊕/2⊕ with one or two positive charges is dominating over the peak [M-C2H5O]⊕. This may be due to the abstraction of one H from an ethylene (type 1, 2, 4) or a methyl (type 3) group with concomitant reduction to Cu(I) (10) or oxidation to Cu(III) (11).
    Additional Material: 7 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19893310405
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  • 3
    Electronic Resource
    Electronic Resource
    Luminescence in the study of lipid metabolism (1989)
    New York : Wiley-Blackwell
    Journal of Bioluminescence and Chemiluminescence 4 (1989), S. 436-445 
    Details
    ISSN: 0884-3996
    Keywords: Bioluminescence ; chemiluminescence ; lipid metabolism ; LDL oxidation ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Using bioluminescence assays for glycerol, free fatty acids, β-hydroxybutyrate and lactate, we were able to perform complex studies of human energy and lipid metabolism both in serum samples in vivo and in isolated fat cells in vitro. These studies would have been impossible without reliable, specific and highly sensitive luminescence methods. Oxidatively modified low density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis. Adaptation of a chemiluminescence assay for lipid hydroperoxides to LDL isolated by specific precipitation from serum makes it possible to measure LDL oxidation in vivo. Cell dependent chemiluminescence was used to investigate whether receptor mediated endocytosis of LDL by macrophages leads to oxygen radical production in these cells. No activation of the membrane NAD(P)H oxidase was observed.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bio.1170040158
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