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  • 2000-2004  (1)
  • 1990-1994  (2)
  • 2002  (1)
  • 1990  (2)
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  • 2000-2004  (1)
  • 1990-1994  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Prevalence of fluconazole-resistant strains of Candida albicans in otherwise healthy outpatients (2002)
    Oxford, UK : Blackwell Science, Ltd
    Journal of oral pathology & medicine 31 (2002), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  In contrast to the immunosupressed patient population, the prevalence of fluconazole-resistant strains of Candida albicans among healthy individuals has not been extensively studied.Methods:  Candida species were cultured form 50 healthy outpatients with clinical signs of oral candidiasis. Following one week of the recommended fluconazole regimen, post-treatment cultures were obtained. Both pre- and post-treatment yeasts were identified and in vitro susceptibility testing was performed using the NCCLS M-27A method. Strains were further differentiated using established cDNA probes.Results:  Forty-four patients (88%) had positive C.albicans cultures prior to treatment. Antifungal susceptibility testing of these strains demonstrated no in vitro resistance to fluconazole. At post-treatment evaluation, eight patients (18%) had persistent signs of infection and 10 patients (23%) had positive Candida sp. cultures despite no clinical signs of infection. DNA analysis confirmed that the same C. albicans strain was present both in the pre-treatment and the post-treatment cultures.Conclusions:  Our results showed that the presence of fluconazole-resistant strains of C.albicans does not appear to be prevalent among healthy outpatients furthermore, in vitro antifungal susceptibility testing does not always predict successful therapy in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0714.2002.310207.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Electrodeposition of polypyrrole layers on aluminium from aqueous electrolytes (1990)
    Springer
    Journal of applied electrochemistry 20 (1990), S. 596-605 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract A screening of twenty aqueous electrolytes for a film-forming electropolymerization of pyrrole with Al was performed. Electrodeposition of well adhering homogeneous polypyrrole layers on aluminium is possible from aqueous electrolytes containing 0.1–0.8M oxalic acid. Pretreatment of the metal by polishing (PD) or by anodic (galvanostatic) activation (GA) is an essential step. In all cases, the Al2O3 surface layer with pores, usually filled with electrolyte, is transformed to a Al2O3 layer with polypyrrole filled pores. The PPy-layers on Al allow an easy cathodic coating with metals like copper. The hydrogenoxalate doped layers exhibit the ususal redox capacity,y=0.3. The sandwich structure Al/Al2O3/PPy represents a condenser with an unusual composite dielectric with the electronically conducting ‘plates’ Al and PPy. According to our impedance measurements, the PPyin the pores is a high resistivity material due to overoxidation in the course of electropolymerization at high local current densities. The composite, Al2O3/overoxidized PPy, exhibits an unusually high permittivity, in the order of 103.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008869
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Regulation and localization of organic osmolytes in mammalian kidney (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 1091-1095 
    Details
    ISSN: 1432-1440
    Keywords: Organic osmolytes ; Rat kidney ; Diabetes insipidus ; Diabetes mellitus ; Hormone treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four organic small molecules belonging to the chemical groups of trimethylamines (betaine and glycerophosphorylcholine) and polyols (sorbitol and inositol) have been shown to act as organic osmolytes in the kidney. When measured along the corticopapillary axis, each exhibits a specific distribution pattern, indicating a specific localization and function. Studying their behaviour under vasopressin treatment in diabetes insipidus rats and after insulin treatment in diabetes mellitus rats confirmed this conclusion: AVP led to a steady increase of sorbitol and glycerophosphorylcholine over 7 days with no effect on inositol levels. Insulin treatment of diabetic rats, on the other hand, decreased sorbitol with a concomitant increase in glycerophosphorylcholine, again without any effect on tubular inositol concentrations. From this and in vitro studies it can be concluded that both hormones act by indirect mechanisms which alter interstitial osmolality. This in turn leads to a change in tubular osmolyte synthesis, uptake and release rates. In addition, the concentrations of the respective precursors glucose and choline influence the formation rates of sorbitol and betaine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01798058
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    Paper (German National Licenses)
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