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  • 1990-1994  (2)
  • 1990  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Nimodipine has no beneficial effect on neurological outcome in a cardiopulmonary arrest model in the rat (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 341 (1990), S. 586-591 
    Details
    ISSN: 1432-1912
    Keywords: Cardiopulmonary arrest ; Resuscitation ; Nimodipine ; Neurological damage ; Neuronal cell death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brain damage after resuscitation from cardiac arrest is believed to be related to calcium influx in ischaemic neurons and to postischaemic calcium-dependent vasospasm. We therefore evaluated the potentially protective effects of the calcium-entry blocker nimodipine in a cardiopulmonary arrest model in the rat. Male Wistar rats were anaesthetized with ketamine (group I) or hexobarbital (group II) and subjected to a KCl-induced cardiac arrest during 7 min (group I) or 12 min (group II). Five minutes after resuscitation, the rats were treated intravenously in a randomized and blind fashion. Group I received either saline or 1 μg · kg−1 · min −1 or 5 μg · kg−1 · min−1 of nimodipine and group II either saline or 1 μg · kg−1 · min−1 of nimodipine. Survival, occurrence of seizures and neurological status were assessed daily during 7 days after resuscitation. On day 7, the brains of the surviving rats were perfusion-fixed and a histopathological evaluation of the hippocampus was performed. Nimodipine, in the doses tested, had no beneficial influence on the 7 day survival rate, nor on the occurrence of seizures and the neurological and histopathological scores in the rats surviving after 7 days. With the highest dose of nimodipine, there was even a trend towards a decrease of the survival rate, probably related to the drug's hypotensive effect. Therefore, our data do not show a protective effect of nimodipine after cardiac arrest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171740
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Placing obsolete hypnotics on prescription and the admission rate for acute poisoning with these drugs (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 519-520 
    Details
    ISSN: 1432-1041
    Keywords: Self-poisoning ; regulation ; hypnotics ; barbiturate ; OTC drugs ; prescribing practice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Since January 1 1988, certain older hypnotics have no longer been available over the counter in Belgium, but can still be dispensed on prescription. The influence of this measure on admission to our Emergency Department for acute poisoning with these hypnotics has been examined. From 1983 to 1987, a mean of 93 patients (range 87 to 99) per year were admitted as compared to 15 and 5 in 1988 and 1989, respectively. For older hypnotics that were on prescription before and after 1st January 1988, there was no decrease in 1988, and a reduction was observed in 1989. There was no change in the number of patients with benzodiazepine poisoning. The data indicate that moving these older hypnotics onto the prescription-only list resulted in a decrease in acute poisoning with them. The reduction observed in 1989 for the older hypnotics that were on prescription before as well as after 1988 may have been due to an influence of the measure on the prescribing habits of physicians.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280947
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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