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  • 1
    Electronic Resource
    Electronic Resource
    Plasma protein binding of phenylbutazone during recovery from acute renal failure (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 69-71 
    Details
    ISSN: 1432-1041
    Keywords: plasma protein binding ; phenylbutazone ; renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma protein binding capacity for phenylbutazone has been studied in 4 patients with acute renal failure. There was an initial important decrease in binding capacity, which gradually returned to normal with improvement of renal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613431
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of beta-adrenergic blockade on blood pressure variation in patients with moderate hypertension (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 325-327 
    Details
    ISSN: 1432-1041
    Keywords: Hypertension ; Variability ; Beta-blockade ; Atenolol ; Arteriosonde
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of beta-adrenergic blockade on blood pressure variation was studied in ten patients with moderate hypertension. Supine systolic and diastolic blood pressures were measured every 5 min during six hours sessions, using an ultrasonic method. Systolic and diastolic variation in each six hour session was defined as the standard deviation of the mean of systolic and diastolic readings made in that period. After 3 weeks of single-blind placebo, a 12 week double-blind randomized crossover study was initiated with placebo (6 weeks) and atenolol (100 mg b. i. d. for 3 weeks and 200 mg b. i. d. for 3 weeks). Systolic and diastolic blood pressure and heart rate decreased significantly (p〈0.01) during atenolol treatment. Diastolic variation did not change significantly, whereas systolic variation decreased slightly but significantly (p〈0.05) when expressed in absolute values, but not when expressed as a percentage of systolic blood pressure. It is concluded that beta-adrenergic blockade decreases blood pressure and heart rate without causing significant changes in spontaneous systolic or diastolic variation
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566528
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  • 3
    Electronic Resource
    Electronic Resource
    Fate of isosorbide dinitrate and mononitrates in patients with renal failure (1981)
    Springer
    European journal of clinical pharmacology 21 (1981), S. 73-76 
    Details
    ISSN: 1432-1041
    Keywords: nitrates ; renal failure ; isosorbide dinitrate ; isosorbide 2-mononitrate ; isosorbide 5-mononitrate ; plasma concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Isosorbide dinitrate 10 mg, isosorbide 5-mononitrate 5 mg and isosorbide 2-mononitrate 5 mg were administered orally to subjects with and without renal failure, and the plasma concentrations of isosorbide dinitrate and of both the mononitrates were measured. There was no striking difference in plasma concentration as a function of time between subjects with and without renal failure, except for a somewhat higher isosorbide 5-mononitrate concentration after administration of this metabolite to uraemic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609591
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of nisoldipine in renal dysfunction (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 207-209 
    Details
    ISSN: 1432-1041
    Keywords: nisoldipine ; renal dysfunction ; pharmacokinetics ; blood pressure control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of nisoldipine have been studied after oral administration of one 10 mg tablet to 3 groups of patients: Group A (n=8) with a mean creatinine of 90 ml/min, Group B (n=8) with a mean creatinine clearance of 12 ml/min and Group C of 12 patients on maintenance haemodialysis. All of them were studied off-dialysis and 7 were also studied on a dialysis day. No significant differences were observed between Groups A, B and C (on an interdialysis day) in AUC (0–7h), tmax, Cmax and plasma protein binding. Unchanged nisoldipine could not be recovered from the urine in any patient. Haemodialysis did not significantly affect AUC, tmax and Cmax, and nisoldipine could not be detected in the dialysate. The results indicate that the dose of nisoldipine need not be changed in patients with renal dysfunction, and that a supplementary dose is not required after haemodialysis. Blood pressure in the uraemics fell more than in the patients with good renal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614560
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of acute renal failure on the protein binding of drugs in animals and in man (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 27-32 
    Details
    ISSN: 1432-1041
    Keywords: Protein binding ; acute renal failure ; phenylbutazone ; warfarin ; papaverine ; quinidine ; digitoxin ; comparative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum protein binding of phenylbutazone has been measured in the rat, guinea pig, cat, rabbit and dog, and the influence on it of renal failure induced by uranyl nitrate injection has been studied. In all species a clearcut decrease in binding was observed after the occurrence of renal failure; the time course of the fall in binding correlated well with development of renal failure. In further experiments, serum protein binding of two acidic drugs (phenylbutazone, warfarin), two basic drugs (papaverine, quinidine) and one neutral drug (digitoxin) was studied in rabbits with experimental renal failure, and the results compared with those obtained in patients with acute renal failure. In the rabbits, a decrease in the binding of phenylbutazone, warfarin, papaverine and quinidine was found, whereas protein binding of digitoxin was unchanged. In man, there was a definite fall in protein binding of phenylbutazone and digitoxin, a small decrease for warfarin and papaverine, and a slight increase for quinidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561784
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  • 6
    Electronic Resource
    Electronic Resource
    Binding ofβ-adrenoceptor blocking drugs to human serum albumin, to α1-acid glycoprotein and to human serum (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 253-256 
    Details
    ISSN: 1432-1041
    Keywords: beta-blocker ; rheumatoid arthritis ; protein-binding ; alpha1-acid glycoprotein ; oxprenolol ; propranolol ; alprenolol ; pindolol ; timolol ; atenolol ; metoprolol ; sotalol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding of 8 β-adrenergic blocking drugs to human serum albumin, to α1-acid glycoprotein and to serum from normal volunteers and from patients with rheumatoid arthritis was studied. Protein binding was determined in vitro using equilibrium dialysis of labelled drug at 25° C. Oxprenolol and propranolol were highly bound to serum, alprenolol, pindolol and timolol to a lesser degree, and atenolol, metoprolol and sotalol were negligibly bound. For the five compounds which were appreciably bound, the mean binding was significantly higher in serum from patients with rheumatoid arthritis than in serum from normal volunteers. For those drugs, binding to α1-acid glycoprotein was higher than to human serum albumin, and binding to a mixture of both proteins approached that to serum from healthy volunteers. For each of these drugs there was a strong correlation between the serum α1-glycoprotein concentration and the percentage binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00545224
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  • 7
    Electronic Resource
    Electronic Resource
    Plasma concentrations and haemodynamic effects of nimodipine in patients resuscitated after cardiac arrest (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 327-333 
    Details
    ISSN: 1432-1041
    Keywords: nimodipine ; pharmacokinetics ; haemodynamics ; cardiopulmonary resuscitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary As the pharmacokinetics of a drug may be altered in haemodynamically compromised patients, the plasma concentrations and haemodynamic effects of the calcium entry blocker nimodipine have been examined in patients resuscitated after out-of-hospital cardiac arrest. In 7 patients nimodipine was infused at increasing rates up to 30 µg·kg−1·h−1. The plasma concentrations increased with increasing dose; at the highest dose a mean steady-state plasma concentration of 22.1 ng·ml−1 was obtained, and the mean plasma clearance was 1.4 l·kg−1·h−1. There were no marked changes in mean arterial blood pressure or heart rate. In 9 other patients nimodipine was given as a bolus infusion of 10 µg·kg−1 over 3 min, followed by a continuous infusion of 30 µg·kg−1·h−1. A mean steady-state plasma concentration of 17.6 ng·ml−1 was obtained and the mean plasma clearance was 1.9 l·kg−1·h−1. Heart rate did not change significantly, but the mean arterial blood pressure fell. The data indicate that in patients resuscitated after cardiac arrest, the pharmacokinetics of nimodipine are not markedly different from patients with other conditions, e.g. subarachnoid haemorrhage. However, if a loading dose is given to obtain a steady-state concentration sooner, there will be a fall in arterial blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558290
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  • 8
    Electronic Resource
    Electronic Resource
    Influence of exercise on plasma concentrations of isosorbide dinitrate (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 213-215 
    Details
    ISSN: 1432-1041
    Keywords: Isosorbide dinitrate ; isosorbide mononitrates ; exercise ; plasma concentrations ; first pass effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary As the fall in hepatic blood flow caused by exercise is expected to decrease the elimination of high extraction drugs, the influence of exercise on the fate of the anti-anginal drug isosorbide dinitrate has been assessed. Isosorbide dinitrate 10 mg was given orally, after an overnight fast, on 2 different days to 7 healthy volunteers and the plasma concentrations of the parent compound and its mononitrate metabolites were measured. Heavy bicycle exercise from the 45 th to the 105 th min after intake of the drug on one of the experimental days did not change the plasma isosorbide dinitrate concentrations as compared to those on the rest day. The concentrations of both mononitrates were lower on the exercise day, but the difference was already present before the exercise started.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609256
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  • 9
    Electronic Resource
    Electronic Resource
    Placing obsolete hypnotics on prescription and the admission rate for acute poisoning with these drugs (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 519-520 
    Details
    ISSN: 1432-1041
    Keywords: Self-poisoning ; regulation ; hypnotics ; barbiturate ; OTC drugs ; prescribing practice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Since January 1 1988, certain older hypnotics have no longer been available over the counter in Belgium, but can still be dispensed on prescription. The influence of this measure on admission to our Emergency Department for acute poisoning with these hypnotics has been examined. From 1983 to 1987, a mean of 93 patients (range 87 to 99) per year were admitted as compared to 15 and 5 in 1988 and 1989, respectively. For older hypnotics that were on prescription before and after 1st January 1988, there was no decrease in 1988, and a reduction was observed in 1989. There was no change in the number of patients with benzodiazepine poisoning. The data indicate that moving these older hypnotics onto the prescription-only list resulted in a decrease in acute poisoning with them. The reduction observed in 1989 for the older hypnotics that were on prescription before as well as after 1988 may have been due to an influence of the measure on the prescribing habits of physicians.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280947
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  • 10
    Electronic Resource
    Electronic Resource
    Comparison of the bioavailability of two slow release preparations of disopyramide (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 629-630 
    Details
    ISSN: 1432-1041
    Keywords: Disopyramide ; slow release ; plasma concentrations ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The bioavailability of two slow release preparations of disopyramide has been compared in a randomized cross-over trial of Rythmodan L. A. 250 mg b. d. and Dirytmin Durettes 300 mg b. d., given to 10 healthy volunteers. The plasma concentrations of disopyramide were measured on the 5th day of each treatment period. With both preparations, plasma concentrations were well sustained. The amount absorbed was slightly lower after Rythmodan L. A. than after Dirytmin Durettes, but the fluctuations over a dosing interval were significantly more pronounced for Dirytmin Durettes than for Rythmodan L. A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279984
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