ISSN:
1432-1041
Keywords:
nitrates
;
renal failure
;
isosorbide dinitrate
;
isosorbide 2-mononitrate
;
isosorbide 5-mononitrate
;
plasma concentrations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Isosorbide dinitrate 10 mg, isosorbide 5-mononitrate 5 mg and isosorbide 2-mononitrate 5 mg were administered orally to subjects with and without renal failure, and the plasma concentrations of isosorbide dinitrate and of both the mononitrates were measured. There was no striking difference in plasma concentration as a function of time between subjects with and without renal failure, except for a somewhat higher isosorbide 5-mononitrate concentration after administration of this metabolite to uraemic patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609591
