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Digitale Medien

Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brain of anorexia nervosa (1990)

Hirata, Y. ; Sawada, M. ; Minami, M. ; [weitere]

Springer

Journal of neural transmission 80 (1990), S. 145-150

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Details

ISSN: 1435-1463

Schlagwort(e): Tyrosine hydroxylase ; tryptophan hydroxylase ; biopterin ; anorexia nervosa

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The activities of tyrosine hydroxylase and tryptophan hydroxylase and contents of biopterin and neopterin were measured for the first time in various regions of human brain from a patient with anorexia nervosa (AN). In AN as compared with controls, tyrosine hydroxylase activity was markedly reduced in all brain regions analyzed, while tryptophan hydroxylase activity and biopterin content had a tendency to increase. Neopterin content did not change dramatically. The opposite changes of tyrosine hydroxylase and tryptophan hydroxylase suggest an imbalance between the activity of catecholaminergic neurons and that of serotonergic neurons, and may be related to pathogenesis of AN.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01257079

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