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  • 2005-2009
  • 1990-1994  (3)
  • 1925-1929
  • 1991  (3)
  • Adjuvant therapy  (1)
  • Polymer and Materials Science
  • intracranial pressure
  • 1
    Electronic Resource
    Electronic Resource
    The contribution of arachidonic acid to the aetiology and pathophysiology of focal brain oedema; studies using an infusion oedema model (1991)
    Springer
    Acta neurochirurgica 113 (1991), S. 57-68 
    Details
    ISSN: 0942-0940
    Keywords: Blood brain barrier ; cerebral blood flow ; intracranial pressure ; arachidonic acid ; brain oedema ; evoked potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Arachidonic acid solution (2 to 15 mg/ml) was infused into the right forebrain white matter of anaesthetised cats over three hours to evaluate its contribution to the genesis and pathophysiology of vasogenic brain oedema. The 0.6 ml infusion increased local white matter water content by a mean of 11.3 ml/100 g tissue but did not increase cortical water content. Histological studies revealed local expansion and trabeculation of the white matter with aggregations of granulocytic neutrophils in the venules and perivenular brain. The adjacent cortical cytoarchitecture was normal. The white matter around the infusion site was stained lightly and over a variable area (15–20 mm2) by intravenously administered Evans Blue dye 2%. Regional cerebral blood flow (rCBF) adjacent to the frontal infusion did not change significantly during the period of infusion and remained similar to rCBF in the contralateral hemisphere. Following the arachidonic acid infusion regional CBF CO2 reactivity was normal and three was no asymmetry of either cortical somatosensory evoked potential (SEP) or motor evoked potential (MEP) waveforms. The increase in brain water content and changes in the ICP and ICP related biodynamics (pressure-volume index, lumped craniospinal compliance and CSF outflow resistance) were similar to those seen following infusion of 0.6 ml saline. These studies suggest that free intraparenchymal arachidonic acid, at concentrations exceeding those occurring in most neuropathological conditions, can increase the normal brain parenchymal capillary permeability but does not disrupt focal cerebrovascular and electrophysiological function. The clinical implications of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402116
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Behandlung des fortgeschrittenen nichtkleinzelligen Bronchialkarzinoms —eine Literaturrecherche der letzten 5 Jahre (1991)
    Springer
    Langenbeck's archives of surgery 376 (1991), S. 32-37 
    Details
    ISSN: 1435-2451
    Keywords: Non-small-cel carcinoma of the lung ; Adjuvant therapy ; Inoperable cases ; Metaanalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen einer Metastudie über adjuvante Therapie und die Therapie der inoperablen nichtkleinzelligen Bronchialkarzinome wurden vom 1. 1. 1985–1. 5. 1990 376 Artikel anhand eines Entscheidungsstammbaumes mit Punkten bewertet. Von maximal 71 Punkten lagen nur 5,4% der Artikel zur adjuvanten Therapie und 7,3% der Publikationen zur Therapie der inoperablen Fallen uber 45 Punkten. Bei den inoperablen Fällen hat die Radiotherapie mit bis zu 11 Monaten medianer Überlebenszeit bei zufriedenstellender Lebensqualität die besten Ergebnisse gezeigt. Die Chemotherapie ermöglicht bei einer Ansprechrate von 13–30% in normdosierten Zweierkombinationen ebenfalls signifikante Steigerungen der Überlebenszeit (7,4 Monate), die im Hinblick auf die Lebensqualität der behandelten Patien ten mit belastenden Nebenwirkungen verbunden sind. Immuntherapie oder Chemo-Radiokombinationsbehandlung können aufgrund der Behandlungstoxizität bei fehlendem Lebensgewinn in den untersuchten Konzepten nicht empfohlen werden. Die adjuvante Therapie bleibt ohne lebensverlängernden Effekt. Hier bleibt die alleinige chirurgische Behandlung die Therapie der Wahl.
    Notes: Summary In the course of a metaanalysis concerning adjuvant therapy and the therapy of inoperable non-small-cell carcinoma of the lung, undertaken from 1. 1. 1985 to 1. 5. 1990, 376 publications were evaluated on a point system based on a decicion tree. Out of a maximum of 71 obtainable points only 5.4% of the publications on adjuvant therapy and only 7.3% of publications on palliative therapy obtained more than 45 points. Regarding inoperable cases X-ray therapy with a median survival of 11 months and satisfactory life quality demonstrated the best results. Significant increases in survival are also possible with chemotherapy (7.4 months) in standard-dose pair combinations which, however, are associated with negative side effects on the treated patients. Immune and radio-chemotherapy cannot be recommended on account of treatment toxicity without a gain in life quality. Adjuvant therapy shows no life-prolonging effect. Consequently surgical treatment remains the first choice of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205125
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Development of seawater-resistant polyurethane elastomers for use as sonar encapsulants (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 42 (1991), S. 911-923 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Polyurethane systems based on aliphatic diisocyanates were evaluated for suitability for use as underwater transducer encapsulants. A preliminary evaluation was performed to select the most promising urethane systems for further development. An investigation was then undertaken to determine the effect of compositional changes on the properties of these urethanes. The compositional parameters investigated were the soft-segment molecular weight, the prepolymer isocyanate content, the composition of the cure formulation, and the cure stoichiometry. These urethanes were subjected to long-term aging in seawater. It was found that this exposure did not significantly effect the physical or dynamic mechanical properties of the urethane.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1991.070420405
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    Paper (German National Licenses)
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