ISSN:
1432-1440
Keywords:
Malnutrition
;
HIV-infection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Study objective: To determine forms of malnutrition and basal metabolism at different stages of immunological impairment in clinically stable patients infected with Human Immunodeficiency Virus (HIV).Design: Cross sectional study.Setting: 53 outpatients with HIV-infection classified according to the Walter Reed staging system (WR1 to WR6).Measurements and main results: 87% of the patients showed some evidence of malnutrition. Reduced body weight was found in 53%, 68% and 25% had decreases in fat and body cell mass, 17% had visceral protein deficiency, whereas extracellular mass and serum triglyceride concentrations were increased in 58% and 30%, respectively. Reduced serum albumin and transferrin closely paralleled immunological depression, whereas alterations in body composition were manifest early during HIV-infection (WR3) and remained unchanged during the transition to the Acquired Immune Deficiency Syndrome itself. Resting metabolic rate increased from WR1 to WR3; it remained within the expected range during later stages (WR4-WR6), but was not appropriately reduced in response to the loss in body cell mass.Conclusions: HIV-infected patients display both, calorie and protein malnutrition. Immunological depression was independent of loss of body mass, but was closely associated to decreases in serum albumin values. Nutritional assessment and intervention should therefore be performed at an early stage of HIV-infection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01665858
Permalink
