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  • 1990-1994  (6)
  • 1993  (4)
  • 1992  (2)
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  • 1990-1994  (6)
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  • 1
    Electronic Resource
    Electronic Resource
    Improvement in survival rate of patients with acral melanoma observed in the past 22 years in Sendai, Japan (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 18 (1993), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: While the incidence of malignant melanoma is much lower in Japanese than in Caucasians, the commonest site of melanoma in Japanese has been reported to be the acral regions of the limbs. The survival rate for acral and nodular melanoma observed at the Department of Dermatology, Tohoku University Hospital in Sendai, Japan from 1969 to 1990 was reviewed. Among 150 melanoma patients 125 (83%) and 17(11%) had primary cutaneous melanoma and mucous membrane melanomas, respectively. Frequent sites for cutaneous melanomas were the sole (31%) and subungual regions (15%). Comparison of the stages of plantar melanoma at diagnosis showed that the proportion of stages III and IV decreased after 1980 with a corresponding increase in those with a tumour thickness of less than 4 mm (stage II). Concurrently, the prognosis of plantar melanoma has improved; the 5-year survival rate in each of the three periods 1969–75, 1976–80 and 1981–85 was 21, 70 and 90%, respectively. This was also the case with subungual melanoma. Such improvements in the prognosis are thought to be mainly due to early detection through the growing public awareness of this life-threatening disease.By contrast cases of nodular melanoma increased sharply after 1980. Among these, the high proportion of patients in advanced stages (stages III and IV) remained static even after 1980, with a resultant low 5-year survival rate in the above mentioned periods of 33, 38 and 18%, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1993.tb00988.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of staurosporine, PMA and A23187 on human melanocyte cultures with dibutyryl cyclic AMP (1992)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 126 (1992), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Staurosporine, a protein kinase (PK) inhibitor, phorbol-12-myristate-13-acetate (PMA), a PKC activator and A23187 calcium ionophore were added to human melanocyte cultures with or without dibutyryl cyclic AMP (dbcAMP). After 2 days' incubation, changes in various melanogenic factors were examined such as tyrosinase activity and the amount of tyrosinase-related protein (TRP) as well as the morphology of the melanocytes, dbcAMP stimulated all the melanogenic factors. Staurosporine increased tyrosinase activity and amount of TRP and caused morphological changes with the formation of numerous dendrites, regardless of the presence of dbcAMP. In contrast, PMA did not significantly affect tyrosinase activity, TRP content or dendrite formation, with or without dbcAMP. The effects of staurosporine on tyrosinase activity and TRP content were completely inhibited by PMA, but PMA did not significantly affect the staurosporine-induced morphological changes. A23187 inhibited both tyrosinase activity and TRP content, regardless of the presence of dbcAMP, but did not affect the morphology of melanocytes. These findings suggest that tyrosinase activity and TRP content are regulated by adenylate cyclase and Ca2+ and partly by PKC, while the morphological features of melanocytes are affected by intracellular cAMP accumulation and by the inhibition of PKC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1992.tb07807.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Elevated levels of soluble ICAM-1 in sera from patients with bronchial asthma (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM-1 in sera reflect the upregulation of ICAM-1 expression in allergic inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb02408.x
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  • 4
    Electronic Resource
    Electronic Resource
    Synovial chondromatosis of the acromioclavicular joint (1993)
    Springer
    Archives of orthopaedic and trauma surgery 112 (1993), S. 152-154 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Synovial chondromatosis involving the acromioclavicular joint is very rare. We report a case of synovial chondromatosis of the acromioclavicular joint associated with synovial cyst formation. Arthrography of the acromioclavicular joint revealed that the loose bodies lay within a synovial cyst which was in communication with the acromioclavicular joint. Synovectomy including removal of the synovial cyst and the loose bodies relieved symptoms completely. The patient was still pain- and recurrence-free at 4 years' follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00449994
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Near-infrared photorefractivity in Cr-doped potassium sodium strontium barium niobate single crystal (1992)
    Springer
    Applied physics 55 (1992), S. 61-64 
    Details
    ISSN: 1432-0630
    Keywords: 42.65 ; 42.70 ; 72.40
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract We report on the photorefractive properties of a Cr-doped (K1−x Na x )2A−2 (Sr y Ba1−y )2−A Nb10O30 (x=0.586, y=0.659, A=1.12) single crystal in the near-infrared spectrum. The sample exhibits photorefractivity for wavelengths up to at least 840 nm where the steady-state two-beam coupling gain is found to be larger than 2 cm−1. Photorefractive gain and decay rate are measured as a function of wavelength, grating spacing and intensity. The wavelength dependence of gain fluctuations in two-beam coupling are also measured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00324603
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Improved fracture toughness of ultrahigh strength steel through control of non-metallic inclusions (1993)
    Springer
    Journal of materials science 28 (1993), S. 853-859 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In recent years, ultrahigh-strength steels, which can be employed successfully at yield strengths of 1400 MPa or higher, have been used increasingly for critical structural applications in aircraft and aerospace vehicles. Most recently, there has been increased demand, however, for ultrahigh-strength steel with superior plane-strain fracture toughness, K IC, and for the steels suitable for large-sized structural applications; isotropy regarding the property has especially been required. One potential solution to this problem is to control nonmetallic inclusions of the steels. This review concentrates on recent topics concerning improved K IC of ultrahigh-strength steels, i.e. low-alloy and highly alloyed secondary hardening steels, through control of non-metallic inclusions. The major factors controlling the property are discussed for each of the techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400864
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