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  • 1995-1999  (16)
  • 1990-1994  (12)
  • 1945-1949
  • 1930-1934
  • 1998  (16)
  • 1992  (12)
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  • 1995-1999  (16)
  • 1990-1994  (12)
  • 1945-1949
  • 1930-1934
Year
  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 34 (1998), S. 1-5 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. The Spirostomum ambiguum toxicity test has been intensively studied in the Department of Environmental Health Sciences, Warsaw University of Medicine for the last 5 years. The purpose of the present work was to develop and evaluate a miniaturized microplate version of the test, called the Spirotox test, and to estimate the toxicity of selected inorganic compounds to the Spirostomum ambiguum. The test was carried out in conventional 24-well (6 × 4) polystyrene multiwell plate. Preliminary test was one control and 11 toxicant concentrations with two duplicates. Definitive test was one control and five toxicant concentrations with three duplicates per concentration. Dilution of the sample was made directly in the plate. Toxicity series of heavy metals based on 24-h LC50 may be established as follows: Cu 〉 Ag 〉 Hg 〉 Cr 〉 Cd 〉 Zn 〉 Ni 〉 Pb 〉 Co 〉 Mn. The series may be divided into four classes: extremely toxic: below 0.1 ppm (Cu, Ag, Hg); very toxic: 0.1–1.0 ppm (Cr, Cd, Zn, Ni); toxic: 1.0–10 ppm (Pb, Co); and low toxic: above 10 ppm (Mn). Anions were much less toxic to S. ambiguum than cations. Using the same classification, only cyanide (CN) was toxic, other anions were low toxic. Toxicity series based on 24-h LC50 may be established as follows: CN 〉 SeO3 〉 Cr2O7 〉 NO2 〉 S2O3 〉WO4 〉 BO3.
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1432-203X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Kidney vetch seedlings were induced to form hairy roots by inoculating their mesocotyls with the wild-type strain 15834 of Agrobacterium rhizogenes or with the A. tumefaciens strain C58C1 containing a binary vector system (the pRiA4b as a helper and the vector pCB1346 bearing a pTiC58-derived isopentenyl transferase gene (ipt, cytokinin biosynthetic gene) under control of its native regulatory sequences). Transgenic lines of three distinct phenotypes were selected: (i) Typically, the pRi15834-transformed tissues were stabilized in vitro and maintained for long periods as aseptic, fast-growing, hormone-independent, plagiotropic hairy root cultures which never regenerated shoots and lost the ability to synthesize opines. Their genomic DNA contained both the TL- and the TR-DNA. (ii) One of the HR-lines transgenic for the T-DNA of pRi15834 (named 52AV34) started to regenerate spontaneously into teratomous shoots. The shoots were found to produce opines and both the TL and TR parts of T-DNA were found to be partly deleted and/or rearranged. They contained phytohormones in similar levels as those found in seed-born shoots. (iii) A practically identical morphogenic response as in the line 52AV34 was observed in the clone 27AV46. However, its shooty, dark-green, slow-growing teratomas were proven to be kanamycin-resistant, opine-producing, and double-transformed by the pRiA4b sequences and the ipt gene. They over-produced auxins as well as cytokinins (mainly indoleacetylaspartic acid and ribosides of zeatin and isopentenyladenine).
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 42 (1992), S. 559-560 
    ISSN: 1432-1041
    Keywords: Mefloquine ; Thai subjects ; pharmacokinetics ; Primaquine ; drug interaction ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 53 (1998), S. 375-376 
    ISSN: 1432-1041
    Keywords: Key words Artesunate ; Dihydroartemisinin ; Pharmacokinetics ; Bioequivalence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 43 (1992), S. 567-569 
    ISSN: 1432-1041
    Keywords: Mefloquine ; Tetracycline ; Thai subjects ; Thai subjects ; drug interaction ; pharmacokinetics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The kinetics of a single oral dose of mefloquine given either alone or with tetracycline has been studied in 20 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with tetracycline (1600 vs 1160 ng · ml−1), as well as a significantly reduced terminal half-life (14.4 vs 19.3 days), mean residence time (11.9 vs 16.0 days) and volume of distribution at steady state (13.3 vs 19.91 · kg−1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 7 days was significantly increased by tetracycline (6.18 vs 4.76 μg · ml−1 · day). The changes in mefloquine disposition after tetracycline treatment are probably due to a reduction in enterohepatic recycling. The initial increase in mefloquine AUC without an apparent increase in side-effects suggests that this combination may have a place in the treatment of multi-drug resistant falciparum malaria.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 66 (1992), S. 646-651 
    ISSN: 1432-0738
    Keywords: Sodium dichromate ; Nephrotoxicity ; Glutathione ; Ascorbate ; Carbohydrate metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ascorbate treatment 30 min prior to sodium dichromate (20 or 30 mg/kg, s.c.) shows higher potency than that of glutathione (GSH) in protecting against both the metabolic disturbance and nephrotoxicity induced by dichromate. However, ascorbate treatment after 2 h of dichromate intoxication had no effect on dichromate-induced blood urea nitrogen (BUN) elevation 3 days after intoxication. In contrast, dichromate-induced glucosuria, which reached maximum levels at 3 days after treatment, was significantly decreased by GSH or N-acetyl cysteine (NAC) treatment, even if its administration was after 24 h of dichromate intoxication. Pretreatment with GSH depletors such as diethyl maleate (DEM) and buthionine sulfoximine (BSO) had no effect on dichromate-induced nephrotoxicity. GSH levels in the liver and kidney were not affected at 3 h after dichromate treatment. However, dichromate significantly increased tissue GSH levels with a marked increase in liver per kidney GSH ratio at 24 h after treatment, if food was withheld subsequent to dichromate treatment, indicating that GSH biosynthesis resulted from the accelerated protein breakdown. These results suggest that GSH-mediated dichromate reduction is not a kinetically favorable pathway in vivo; however, GSH plays an important role in protection against dichromate-induced nephrotoxicity. In addition, the cellular metabolism of dichromate in the early period after treatment is important in the pathogenesis of its nephrotoxicity.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  The seroprevalence to Kaposi’s sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 (HHV-8) was surveyed in human immunodeficiency virus type 1 (HIV-1) carriers with or without skin diseases, and also in HIV-1 negative individuals in Thailand. Using an immunofluorescence assay, the seropositive rates to lytic antigens of HHV-8 in HIV-1 carriers with or without skin diseases were 25% and 7.4%, respectively, but none of HIV-1 negative individuals had antibody. The seroprevalence to HHV-8 antigens was high in HIV positive individuals with low CD4/CD8 ratio, suggesting that HHV-8 is reactivated during the immunosuppressive state. Several polypeptides with apparent molecular weights of 34–38,000 and 40,000, which were specific to HHV-8, were identified by the immunoprecipitation test using the seropositive sera. Our results suggested that HHV-8 co-existed with HIV in HIV-1 carriers and the existence of HHV-8 may be associated with clinical features in the skin.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1573-482X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Cobalt ferrite/metal composite thin films with a saturation magnetization (Ms) of ∼0.729 Weber m-2 were prepared by a reactive sputtering method. The Ms of the thin films increased with increasing substrate temperature. The microstructures of the thin films were identified by a convergent beam electron diffraction method. For the thin films deposited at high substrate temperatures (〉300 °C), CoxFe1-x (x≈0.62) metal alloys were separated from the cobalt ferrite matrix. A cobalt ferrite phase was determined as CoFe2O4 with a cubic structure (a0=0.839 nm) and a space group of Fd3m, while a metal phase CoxFe1-x (x≈0.62) with a b.c.c. structure (a0=0.289 nm) and a space group of Im3m. © 1998 Kluwer Academic Publishers
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 16 (1992), S. 133-135 
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs présentent les résultats de 36 ostéotomies inter-trochantériennes effectuées pendant une période de 15 ans. Les indications chirurgicales ont été les suivantes: déplacement chronique de la tête fémorale avec un angle tête-col (ATC), mesuré sur la radiographie de profil, supérieur à 30°, associé à un signe de Trendelenburg positif et/ou une marche en rotation externe. L'âge moyen des malades au moment de l'opération était de 14,1 ans. Le recul moyen des observations est de 7,5 ans. Deux fois l'ostéotomie a du être reprise précocément durant la période post-opératoire à cause d'un redéplacement. Les complications les plus importantes ont été deux nécroses de la tête fémorale et quatre coxa vara. L'ATC a diminué en moyenne de 30°. Les résultats ont été évalués selon la cotation d'Ireland et Newman: il y a 14 bons, 18 médiocres et 4 mauvais résultats cliniques et 13 bons, 19 médiocres et 4 mauvais résultats radiologiques. Les meilleurs résultats ont été obtenus avec un ATC final de moins de 10°.
    Notes: Summary Thirty six patients with a chronic slip of the capital femoral epiphysis and a femoral headneck angle of more than 30 degrees, as measured in a lateral radiograph, were treated by intertrochanteric osteotomy. The patients had an abnormal gait, an average age of 14.1 years and symptoms for an average of 14.5 months. The postoperative complications included two patients with avascular necrosis of the femoral head, four with coxa vara and two with loss of position requiring further operation. At an average of 7.5 years after operation 14 were good, 18 fair, and 4 poor on clinical assessment, with 13 good, 19 fair and 4 poor when judged by radiographs. Patients with complications had only fair or poor results. A postoperative head-neck angle of less than 10 degrees indicated a good result.
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and computational fluid dynamics 11 (1998), S. 109-134 
    ISSN: 1432-2250
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Turbulent flow over a sinusoidal solid wavy surface was investigated by a direct numerical simulation using a spectral element technique. The train of waves has an amplitude to wavelength ratio of 0.05. For the flow conditions (Re=hU b/2ν= 3460) considered, adverse pressure gradients were large enough to cause flow separation. Numerical results compare favorably with those of Hudson's (1993) measurements. Instantaneous flow fields show a large variation of the flow pattern in the spanwise direction in the separated bubble at a given time. A surprising result is the discovery of occasional velocity bursts which originate in the separated region and extend over large distances away from the wavy wall. Turbulence in this region is very different from that near a flat wall in that it is associated with a shear layer which is formed by flow separation.
    Type of Medium: Electronic Resource
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