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  • 2000-2004
  • 1990-1994  (4)
  • 1980-1984
  • 1970-1974
  • 1992  (4)
  • 1
    Electronic Resource
    Electronic Resource
    A case of Rathke's cleft cyst within a pituitary adenoma presenting with acromegaly — do “transitional cell tumors of the pituitary gland” really exist? (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 211-215 
    Details
    ISSN: 1432-0533
    Keywords: Pituitary adenoma ; Plurihormonal adenoma ; Immunohistochemistry ; Acromegaly ; Rathke's cleft cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of multiple large Rathke's cleft cyst within a pituitary adenoma presenting with acromegaly is reported. Rathke's cleft cyst within a pituitary adenoma is rare condition, and this is the first report of such a case presenting with acromegaly. An electron microscopic and an immunohistochemical analysis proved that the cyst within the pituitary adenoma of this case differs from cysts found in the embryonic stage of the pituitary gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308482
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The relationship between c-myc protein expression, the bromodeoxyuridine labeling index and the biological behavior of pituitary adenomas (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 361-364 
    Details
    ISSN: 1432-0533
    Keywords: c-myc protein ; Bromodeoxyuridine ; Pituitary adenoma ; Malignancy ; Labeling index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the relationship between the percentage of c-myc protein-labeled cells, the bromodeo-xyuridine (BrdUrd) labeling index (LI) and clinical malignancy in pituitary adenomas, we studied 31 cases of pituitary adenomas. Tumor invasiveness, recurrence, tumor size and the length of illness were evaluated from operative findings, magnetic resonance imaging findings, and the clinical course. Each pituitary adenoma was scored to represent the degree of clinical malignancy. An hour before excision of the tumor, we administered BrdUrd intravenously. Surgical materials were fixed in 70% alcohol and embedded in paraffin. Both hematoxylin and eosin staining and immunohistochemical staining were performed using a monoclonal antibody for both anti-BrdUrd and anti-c-myc protein. Among pituitary adenomas, there was a significantly low percentage of c-myc protein-labeled cells in cases with acromegaly. The percentage of c-myc protein-labeled cells in the pituitary adenomas tended to increase with increase with the total scores of clinical malignancy. The BrdUrd LI was lower than 1% in almost all cases of pituitary adenomas, and it showed no correlation with their clinical malignancy. In conclusion, determination of the percentage of c-myc protein-labeled cells in pituitary adenomas proved to be useful for evaluating their clinical malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713526
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Combined effects of ozone and cigarette smoke on airway responsiveness and vascular permeability in guinea pigs (1992)
    Springer
    Lung 170 (1992), S. 311-322 
    Details
    ISSN: 1432-1750
    Keywords: Guinea pig ; Ozone ; Cigarette smoke ; Airway hyper-responsiveness ; Vascular permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of combined exposure to ozone and cigarette smoke on airway responsiveness and tracheal vascular permeability, compared with those of single exposure were examined in guinea pigs. Airway responsiveness was assessed by measuring the specific airway resistance (sRaw) as a function of increasing concentration of inhaled methacholine aerosol immediately, 5 hr, and 24 hr after exposure. In a parallel study, tracheal vascular permeability was quantified by measuring the tracheal extravasation of intravenously administered Evans blue dye. Neither exposure to 1 ppm ozone for 30 min nor 5 puffs of cigarette smoke increased airway responsiveness or vascular permeability at any time after exposure. Combined exposure to 1 ppm ozone for 30 min and 5 puffs of cigarette smoke caused airway hyperresponsiveness and increased vascular permeability immediately after exposure. Exposure to 1 ppm ozone for 90 min increased both airway responsiveness and vascular permeability immediately after exposure. Exposure to 10 puffs of cigarette smoke increased airway responsiveness but not vascular permeability immediately after exposure. Combined exposure to 1 ppm ozone for 90 min and 10 puffs of cigarette smoke increased both airway responsiveness and vascular permeability immediately after exposure. The combined exposure to ozone and cigarette smoke thus increased both airway responsiveness and tracheal vascular permeability to a greater extent than did exposure to a single agent, suggesting that a combination of air pollutants has a more deleterious effect both on airway responsiveness and on tracheal vascular permeability than does either agent alone in guinea pigs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177577
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Cloning and characterization of a repetitive sequence fromPneumocystis carinii (1992)
    Springer
    Parasitology research 78 (1992), S. 23-27 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Four repetitive sequence clones measuring 10.9–23.4 kb in length were isolated from the genomic library ofPneumocystis carinii. Restriction enzymes mapping and cross-hybridization studies revealed that these clones are interrelated and that they derive from the common repeat unit, which is specific forP. carinii. Dot-blot analysis suggested that the copy number of the repeat sequence is about 100, assuming that the genome size is 1.5×107 bp. Interestingly, the repetition unit extended over at least 23.4 kb and included long, 5.2-kb inverted repeats, for example, A-B-A′-C, in which A′ is the inversion of A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00936176
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    Paper (German National Licenses)
    Fulltext
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