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Digitale Medien

Failure to detect any effect of amalgam restorations on peripheral blood lymphocyte populations (1992)

Wilhelm, M. ; Dünninger, P. ; Rüppel, R. ; [weitere]

Springer

Journal of molecular medicine 70 (1992), S. 728-734

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ISSN: 1432-1440

Schlagwort(e): Amalgam ; Lymphocytes ; Immune system

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Dental amalgam has been considered to have adverse side effects on the immune system. Reports have been contradictory, indicating both an increase and a decrease in peripheral blood lymphocyte counts associated with amalgam restorations. We investigated two groups of patients, one of which was treated with amalgam restorations for the first time. In the other group, all existing amalgam fillings were removed. Prior to and after treatment, we determined the absolute and relative numbers of granulocytes, lymphocytes, monocytes, T cells, B cells, cytotoxic T cells, helper T cells and natural killer cells. In addition, functional investigations of T cells were performed. We failed to find any effect of amalgam restorations on the immune system in terms of the parameters investigated.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00180738

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Digitale Medien

γ/δ Receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis (1992)

Wilhelm, M. ; Meyer, P. ; Batram, C. ; [weitere]

Springer

Annals of hematology 65 (1992), S. 111-115

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ISSN: 1432-0584

Schlagwort(e): Interferon-γ ; Hematopoiesis ; γ/δ ; γ/δ T cells ; Cutaneous T-cell lymphoma

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Recently we described a cutaneous T-cell lymphoma expressing the γ/δ T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a significant suppression of myeloid/monocyte colony formation (GM-CFU) compared with normal controls. This was not due to infiltration of the BM with lymphoma cells. We speculated that a soluble factor either secreted or induced by the lymphoma cells might be responsible for the marked suppression of hematopoiesis in this patient. From a skin biopsy with infiltrating γ/δ T-lymphoma cells we established T-cell clones bearing the γ/δ T-cell receptor and resembling the phenotype of the lymphoma cells. The supernatant (SN) of these γ/δ T-cell clones reduced the number of colonies in a CFU-GM assay (using normal control BM) in comparison to SN of α/β T-cell clones established from the same biopsy. This suppression was seen mainly on day 7 of culture and was not neutralized by the addition of placenta-CM. The main mediator of this suppression seems to be IFN-γ,since it was detectable in high amounts in the SN of these γ/δ T-cell tumor clones as well as in the serum of the patient. In addition, anti-IFN-γ antibodies can reverse the T-cell SN-mediated suppression of CFU-GM. We conclude that high serum levels of interferon-γ, which is secreted in high amounts from γ/δ T-cells grown from a biopsy of a cutaneous lymphoma, can suppress hematopoiesis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01695808

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