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Effects of a high-cholesterol diet on arterial wall thickness and vascular reactivity in young rabbits (1992)

Ludwig, M. ; Stumpe, K. O. ; Sauer, A. ; [et al.]

Springer

Journal of molecular medicine 70 (1992), S. 105-112

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ISSN: 1432-1440

Keywords: Cholesterol diet ; Arterial wall thickness ; Vascular reactivity ; Duplex sonography

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Cholesterol enrichment of arteries may induce biochemical and structural abnormalities in vascular smooth muscle resulting in increased arterial contractile sensitivity. We studied the effects of a high-cholesterol diet on arterial structural properties and vascular reactivity in young rabbits. In vivo measurements of aortic intimal-plus-medial thickness using high resolution ultrasound imaging were obtained before and after 3 weeks of a high-cholesterol diet in 12 rabbits (group 2) and compared to data from 12 animals a cholesterol-free diet fed (group 1). Six rabbits (group 3) were studied before and after a 3-week, high-cholesterol diet and after a subsequent 13-week, cholesterol-free recovery diet. Blood pressure responsiveness to noradrenaline was evaluated before and at the end of each diet period. In groups 2 and 3, high dietary cholesterol caused an increase in intimal-plus-medial thickness from 0.31 mm and 0.33 mm to 0.88 mm and 0.89 mm, respectively (p〈0.001). Plasma cholesterol concentration rose from 0.9 ±0.26 mmol/l to 36.7 ± 8.56 mmol/l. There was no change in group 1. In group 3, intimal-plus-medial thickness remained increased (1.01 mm) following the cholesterol-free recovery diet despite normal plasma cholesterol. Blood pressure responsiveness to noradrenaline was markedly increased after the high-cholesterol diet (p〈0.001) in groups 2 and 3 and after the cholesterol-free recovery diet in group 3 (p〈0.001), and was directly related to intimal-plus-medial thickness (r=0.84;p〈0.001). The data indicate that short-term high dietary cholesterol in the early life of rabbits causes long-lasting biochemical and structural arterial wall abnormalities, which might not only explain the observed increase in blood pressure responsiveness to noradrenaline, but could also lead to persistent functional vascular smooth muscle alterations. The result may be a predisposition to increased vascular smooth muscle response to high dietary cholesterol in adult life and development of high blood pressure and atherosclerosis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00227349

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Micro-FTIR studies on cellulose nitrate fibres of different degrees of substitution (1992)

Ludwig, M. ; Fengel, D.

Weinheim : Wiley-Blackwell

Acta Polymerica 43 (1992), S. 261-265

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ISSN: 0323-7648

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: Cellulosenitrat-Fasern mit unterschiedlichem Substitutionsgrad wurden mittels der Mikro-FTIR-Technik analysiert. Die Suspension der Fasern in Nujol resultierte in einer verbesserten Auflösung der Spektren. Eine näherungsweise Quantifizierung des Substitutionsgrades wurde durch die Anwendung einer Entfaltungsfunktion im Absorptionsgebiet der OH-Valenzschwingungen erreicht. Die relative Bandenhöhe bei 3500 bis 3535 cm-1 erwies sich als ein Maß für den Nitrierungsgrad der Cellulosefasern. Der Einfluß der Ausgangscellulose sowie der Nitrierungsmethode und von Vorbehandlungen auf die Spektren von Einzelfasern wurde untersucht.

Notes: Cellulose nitrate fibres of different degrees of substitution were analyzed by micro-FTIR technique. A suspension of the fibres in Nujol resulted in improved recording conditions. An approach to quantification of the degree of substitution was reached by applying a deconvolution function to the absorbance range of the OH valency vibrations. The relative band height at 3500 to 3535 cm-1 was found to be a measure of the nitration degree of cellulose fibres. The influences of the original cellulose as well as the kind of nitration and pretreatment on the spectra of individual fibres were studied.

Additional Material: 10 Ill.