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  • 1990-1994  (6)
  • 1955-1959
  • 1992  (6)
  • 23.20.−g  (2)
  • Life and Medical Sciences  (2)
  • p53  (2)
  • supercritical fluid chromatography
Source
Material
Years
  • 1990-1994  (6)
  • 1955-1959
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas (1992)
    Springer
    Virchows Archiv 421 (1992), S. 223-228 
    Details
    ISSN: 1432-2307
    Keywords: p53 ; Oncogenes ; Carcinoma ; Prostate gland ; Lung ; Breast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study we analysed the expression ofp53 protein in a total of 143 carcinomas immunohistochemically. These consisted of 34 prostatic adenocarcinomas, 59 lung and 50 breast carcinomas. In 28 cases, an average of 2–3 additional sections from different tumour areas were analysed. Forty-nine of the 143 carcinomas (34%) showed typical nuclear immunoreactivity by immunohistochemical staining with thep53 antibody CM-1. Two of the 34 prostatic carcinomas (6%) werep53 positive while 25 of the 59 lung carcinomas (43%) and 22 of the 50 breast carcinomas (44%) showed positivity forp53. By grade: 49% of grade III tumours, 36% of grade II and 5% of grade I tumours werep53 positive. There were significantly morep53-positive cases in grade II–III tumours than in grade I tumours (P= 0.001) when all tumours were taken into account. Further, there were significantly morep53-positive cases in grade III than in grade I–II tumours (P=0.001). In lung tumours there were significantly morep53-positive cases in grade II–III tumours than in grade I tumours (P=0.018). Similarly, there were significantly morep53-positive tumours in grade III breast tumours than in grade I–II tumours (P=0.003). The low incidence ofp53 positivity in prostate carcinomas suggests that mutations of thep53 gene are not as frequent in the neoplastic transformation of these tumours as in lung or breast carcinomas. The association ofp53 positivity with tumours of higher grade suggests thatp53 mutations lead to tumours of a more aggressive type. The analysis of tumours by multiple sections indicates thatp53 positivity is not evenly distributed in tumour tissue. Therefore, analysis of additional tumour areas may reveal positivity some cases, which is not evident if only one section is studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611179
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lowp53 protein expression in salivary gland tumours compared with lung carcinomas (1992)
    Springer
    Virchows Archiv 421 (1992), S. 415-420 
    Details
    ISSN: 1432-2307
    Keywords: Salivary gland ; Salivary gland tumours ; Oncogenes ; p53 ; tumour suppressor genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-one salivary gland tumours (23 pleomorphic adenomas, 5 Warthin's tumours, 12 mucoepidermoid carcinomas, 7 adenoid cystic carcinomas, 3 undifferentiated carcinomas and 1 acinic cell tumour) and 27 lung carcinomas (18 squamous cell carcinomas, 6 adenocarcinomas and 3 small cell carcinomas) were analysed immunohistochemically for the expression ofp53 nuclear phosphoprotein. Eight out of 51 (16%) salivary gland tumours werep53 positive. Three of these were benign and 5 malignant. All 3 benign salivary gland tumours were pleomorphic adenomas and expressed only occasional nuclear positivity with less than 1% of tumour cells positive. Of the 5p53-positive malignant tumours, 3 were mucoepidermoid carcinomas and 2 undifferentiated carcinomas. The malignant salivary gland tumours expressed more than 1% of positive nuclei in every case. Seventeen lung carcinomas werep53 positive (63%). Thirteen of these were squamous cell carcinomas, 3 were adenocarcinomas and 1 small cell lung carcinoma. The results show that mutations of thep53 gene may be infrequent in salivary gland tumours when compared with lung carcinomas. The relatively indolent course of some histological types of malignant salivary gland tumours could be associated with the preservation of the non-mutatedp53 gene in most of these tumours. The presence ofp53 positivity in some pleomorphic adenomas might, on one hand, suggest thatp53 gene alterations are also present in these tumours; on the other hand, the accumulation of thep53 protein in these tumours might also be due to some unknown mechanism, not necessarily related top53 gene mutation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606914
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  • 3
    Electronic Resource
    Electronic Resource
    Radiationless transition probabilities in muonic209Bi (1992)
    Springer
    The European physical journal 342 (1992), S. 245-246 
    Details
    ISSN: 1434-601X
    Keywords: 13.10.+q ; 23.20.−g ; 36.10.−k ; 36.10.Dr
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The probability for non-radiative (n.r.) excitations in muonic209Bi was determined from a (μ −,γγ)-measurement by comparing the intensities of muonic X-ray transitions in single and coincidence spectra. The values of Pn.r(3p→1s)=(17.9±2.0)% and Pn.r.(3d→1s)=(3.0±2.2)% were measured for the first time. The strength of the n.r. decay of the 2p-level was found to be (4.2±2.2)%. The n.r. transition probabilities of two subcomplexes of the (2p→1s)-transition leading to different mean excitation energies are (3.2±1.8)% and (5.0±2.0)%, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01288477
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  • 4
    Electronic Resource
    Electronic Resource
    Nuclear excitation and prompt fission in muonic238U (1992)
    Springer
    The European physical journal 342 (1992), S. 111-120 
    Details
    ISSN: 1434-601X
    Keywords: 13.10.+q ; 14.60.Ef ; 23.20.−g ; 25.30.−c ; 25.85.−w ; 27.90.+b ; 36.10.−k
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A study of muonic238U has been performed in a combined (μ −,γ f) and (μ −,γγ) coincidence experiment to investigate the role of non-radiative transitions and their fission probabilities. An augmentation of the outer fission barrier ofΔE b =(0.6±0.1) MeV due to the presence of the muon is deduced. A significant contribution to the prompt fission yield not only results from the (2p→1s) and (3d→1s) non-radiative transitions, but also from other radiationless transitions. Specifically, the measured fission probabilities of the transitions (2p→1s), (3d→1s), and (3p→1s) are (1.5±0.4)%, (5.7±1.7)%, and (5.3±1.9)%, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294496
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  • 5
    Electronic Resource
    Electronic Resource
    A multiplanar anatomic study of the cervical proximal nerve roots and spinal nerves (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 5 (1992), S. 433-440 
    Details
    ISSN: 0897-3806
    Keywords: anatomy ; spine ; sheath ; Life and Medical Sciences ; Miscellaneous Medical
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: An anatomic study focused on the proximal cervical spinal nerves has not been reported. Therefore, we dissected the cervical spinal nerves of three cadavers and examined stained sections in parasagittal and axial planes through the proximal cervical spinal nerves and root sheaths. These studies documented distinct segments of the spinal nerve which had not been completely described in the previous anatomic studies. The sheath originates from the dural sac as a common sleeve, divides into two sleeves, one containing the ventral root and one the dorsal root, and then distal to the dorsal root ganglion fuses again into one sleeve. A space, the interradicular cleft, separates the dorsal and ventral portions of the sleeve. The proximal segment of the spinal nerve proper distal to the dorsal root ganglion is composed of multiple small fascicles surrounded by a dense epineurium. The presence of an interradicular cleft in the cervical nerve root sheath and of fascicles in the cervical spinal nerve has significance for imaging of the cervical spinal nerves and for the pathogenesis of symptoms in cases of partial compression. © 1992 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ca.980050603
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  • 6
    Electronic Resource
    Electronic Resource
    Dihydropyridine calcium antagonist modulates cholesterol metabolism and eicosanoid biosynthesis in vascular cells (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 48 (1992), S. 393-400 
    Details
    ISSN: 0730-2312
    Keywords: calcium channel blocker ; atherosclerosis ; LDL ; LDL-receptor ; vascular smooth muscle ; PGI2 ; cyclic AMP ; cyclooxygenase ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Recent clinical studies have shown that calcium channel blockers can retard and possibly reduce the angiographic progression of coronary artery disease. Calcium channel blockers also inhibit dietary-induced atherosclerosis in animal models of this disease. In this study, we delineate potential cellular and molecular mechanisms by which nicardipine, a dihydropyridine calcium antagonist, may alter lipoprotein and cholesterol trafficking, affect the regulatory signal transduction pathways involved in accelerating cholesteryl ester (CE) catabolism in vascular smooth muscle cells, and modulate cell-cell interactions of vascular and inflammatory cells. We demonstrate in arterial smooth muscle cells that nicardipine increases (1) LDL binding, uptake, and degradation, (2) RNA transcript levels for the LDL receptor, (3) CE catabolic activity, (4) PGI2 release, and (5) RNA transcript levels for cyclooxygenase. Furthermore, nicardipine blocked cytokine-induced monocyte adhesion to endothelial cells and smooth muscle cells. Taken together, these findings support the hypothesis that nicardipine may function as an anti-atherosclerotic agent by promoting CE catabolism and cholesterol clearance and by reducing monocyte adhesion to the activated endothelium.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240480408
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    Paper (German National Licenses)
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